A5100940677- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Myasthenia Gravis and Thymoma
- Circular RNAs in diseases
- Genomics and Phylogenetic Studies
- Bladder and Urothelial Cancer Treatments
- Anesthesia and Pain Management
- Ocular Oncology and Treatments
- Sepsis Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Geochemistry and Elemental Analysis
- Congenital Diaphragmatic Hernia Studies
- Gestational Trophoblastic Disease Studies
- Epigenetics and DNA Methylation
- Data Visualization and Analytics
- Parkinson's Disease and Spinal Disorders
- RNA regulation and disease
- Signaling Pathways in Disease
- Ectopic Pregnancy Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Artificial Intelligence in Healthcare and Education
- Single-cell and spatial transcriptomics
- Robotics and Sensor-Based Localization
Shaanxi Normal University
2025
Wenzhou Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
Xi'an University of Technology
2025
Wuxi People's Hospital
2023-2024
Nanjing Medical University
2023-2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024
Zhejiang University
2024
First Affiliated Hospital of Guangzhou Medical University
2024
Abstract Consumption of dietary fiber and anthocyanin has been linked to a lower incidence colorectal cancer (CRC). This study scrutinizes the potential antitumorigenic attributes black rice diet (BRD), abundantly rich in anthocyanin. Our results demonstrate notable effects mice on BRD, indicated by reduction both size number intestinal tumors consequent extension life span, compared control diet‐fed counterparts. Furthermore, fecal transplants from BRD‐fed germ‐free led decrease colonic...
Long noncoding RNAs (lncRNAs) play essential roles in the tumorigenesis of gastric cancer. However, influence lncRNA methylation on cancer stem cells (GCSCs) remains unclear.
Abstract G-quadruplexes (G4s) are non-canonical four-stranded structures and emerging as novel genetic regulatory elements. However, a comprehensive genomic annotation of endogenous G4s (eG4s) systematic characterization their network still lacking, posing major challenges for eG4 research. Here, we present EndoQuad (https://EndoQuad.chenzxlab.cn/) to address these pressing issues by integrating high-throughput experimental data. First, based on high-quality genome-wide eG4s mapping datasets...
Abstract The dysfunction of stress granules (SGs) plays a crucial role in the pathogenesis various neurological disorders, with T cell intracellular antigen 1 (TIA1) being key component SGs. However, and mechanism TIA1‐mediated SGs experimental autoimmune encephalomyelitis (EAE) remain unclear. In this study, upregulation TIA1, its translocation from nucleus to cytoplasm, co‐localization G3BP1 (a marker SGs) are observed spinal cord neurons EAE mice. Deletion TIA1 CNS alleviates...
In this paper, an autonomous landing guidance strategy is proposed for quad-UAVs, including marker detection, altitude estimation, and adaptive commands generation. A double-layered nested designed to ensure that the can be captured both in high low altitudes. deep learning-based detection method where intersection of union replaced by normalized Wasserstein distance computation non-maximum suppression improve accuracy. The UAV measured inertial measurement unit fused with vision-based...
Introduction Myasthenia Gravis (MG) is an autoimmune disorder characterized by impaired neuromuscular junction (NMJ) transmission. Current treatments for MG include steroids and nonsteroidal immunosuppressive therapies (NSISTs). However, approximately 20% of patients show a poor response to these therapies, which are often associated with significant side effects. Telitacicept, novel recombinant fusion protein targeting the BAFF/APRIL pathway, has shown promise in treating diseases,...
The emergence of biologics for the treatment generalized myasthenia gravis (gMG) has increased therapeutic options, but evidence on their flexible use remains limited. This study retrospectively analyzed gMG patients treated with efgartigimod followed by telitacicept. A retrospective analysis was conducted Outcomes included changes in Quantitative Myasthenia Gravis (QMG) and Gravis-Activities Daily Living (MG-ADL) scores from baseline to weeks 13 28, Minimal Manifestation Status (MMS),...
Background: Accumulating evidence supports the important role of inflammation in tumorigenesis and progression. Squamous cell carcinoma-associated antigen (SCC-Ag) is a tumor marker widely used to predict prognosis patients with cervical squamous carcinoma. This paper explored predictive value combined detection neutrophil-to-lymphocyte ratio (NLR) SCC-Ag for locally advanced cancer (LACC). Methods: A retrospective analysis was conducted on 190 LACC who underwent concurrent chemoradiotherapy...
RPF2 plays a crucial role in promoting epithelial-mesenchymal transition (EMT) and regulating metastasis colorectal cancer (CRC). By analyzing data from the TCGA GEO databases, we observed significantly elevated expression CRC, which correlated with EMT markers. Further investigations using stable overexpression knockdown cell lines demonstrated that facilitates activation through AKT/GSK-3β signaling pathway. Notably, CARM1 was identified as key downstream effector of RPF2. Selective...
Ribosome production factor 2 homolog (RPF2) plays an important role in the life processes of ribosomal biogenesis; however, function and mechanism RPF2 tumors are unclear. The present study demonstrated that expression is involved chemoresistance colorectal cancer (CRC) cells. current upregulation CRC promoted resistance to chemotherapeutic agents cells, whereas knockdown leads increased sensitivity chemotherapy. In addition, it was found overexpression led increase ATP‑binding cassette...
Abstract The volume of ribonucleic acid (RNA)-seq data has increased exponentially, providing numerous new insights into various biological processes. However, due to significant practical challenges, such as heterogeneity, it is still difficult ensure the quality these when integrated. Although some control methods have been developed, sample consistency rarely considered and are susceptible artificial factors. Here, we developed MassiveQC, an unsupervised machine learning-based approach,...
Abstract Background Postoperative pain is a common problem that occurs in pediatric patients following neurosurgery which may lead to severe complications. Dexmedetomidine commonly used adjuvant medicine craniotomy owing its sedative, amnestic, analgesic, and neuroprotective properties. Besides, studies suggest lidocaine has similar effects on sedation, analgesia, neuroprotection. Both two adjuvants can reduce postoperative after adults. However, it still unknown whether dexmedetomidine or...
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has been going on for over a year and reemerged in several regions.Therefore, understanding the covertness of COVID-19 is critical to more precisely estimating size, especially population hidden carriers (those with very mild or no symptoms).Methods: A stochastic dynamic model was proposed capture transmission mechanism depict COVID-19.The captured unique features COVID-19, changes diagnosis criteria, escalating containment...
Abstract Rheumatoid arthritis-interstitial lung disease (RA-ILD), associated with Arthritis (RA), typically manifests as usual interstitial pneumonia (UIP) and non-specific (NSIP). However, the pathogenic mechanisms underlying RA its related ILD are not fully understood. The progression of single-cell sequencing technology has enhanced our comprehension inflammatory environment, offering potential insights into inflammation-related cells. In this study, we conducted cell communication...
Uveal melanoma (UVM) prognosis and the possibilities for targeted therapy depend on a thorough understanding of immune infiltration features analysis genomic signatures. Leveraging multi-omics data from The Cancer Genome Atlas GEO datasets, we employed an unsupervised clustering algorithm to categorize UVM into immune-related subgroups. Subsequent revealed two distinct subtypes, each characterized by unique mutations microenvironment disparities. aggressive UMCS2 subtype exhibited higher TNM...
SPARC is an acidic, cysteine-rich, calcium-binding member of the non-collagen glycoproteins originating in bone. Although implicated development several cancers, functions and mechanisms remain unclear. The aim this study was to investigate whether smooth muscle cell (SMC)-associated acts important tumour suppressor lung adenocarcinoma (LUAD). inhibits immune evasion LUAD by suppressing CD276 functionality. We downloaded RNA-sequencing data from patients with Cancer Genome Atlas identified a...
Horizontal gene transfer (HGT) from one organism to another, according some researchers, can be abundant in the evolution of species. A phylogenetic network is a structure that describes HGTs among Several studies have proposed methods construct networks predict based on parsimony values. Existing definitions values for are assumption each site or segment evolves independently along different trees network. However, current study, we define novel value, denoted p definition, networks,...