A5022870859- Geological and Geochemical Analysis
- Geochemistry and Geologic Mapping
- earthquake and tectonic studies
- Geochemistry and Elemental Analysis
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- High-pressure geophysics and materials
- Radioactive element chemistry and processing
- Plant-Microbe Interactions and Immunity
- Geomagnetism and Paleomagnetism Studies
- Clay minerals and soil interactions
- vaccines and immunoinformatics approaches
- RNA Research and Splicing
- Extraction and Separation Processes
- Advanced Condensed Matter Physics
- SARS-CoV-2 and COVID-19 Research
- Single-cell and spatial transcriptomics
- Crystal Structures and Properties
- Microbial Metabolism and Applications
- Monoclonal and Polyclonal Antibodies Research
- Probiotics and Fermented Foods
- Plant Disease Resistance and Genetics
- Zebrafish Biomedical Research Applications
- Immune cells in cancer
- Immunotherapy and Immune Responses
University of Saskatchewan
2023-2025
Yunnan Agricultural University
2025
West China Medical Center of Sichuan University
2020-2024
Shihezi University
2024
Chinese Academy of Sciences
2019-2024
Guangzhou Institute of Geochemistry
2018-2024
Yunnan University
2018-2024
University of Chinese Academy of Sciences
2019-2024
Sichuan University
2022-2023
Guangdong Institute of New Materials
2023
In recent years, the explosive growth of spatial technologies has enabled characterization heterogeneity tissue architectures. Compared to traditional sequencing, transcriptomics reserves information each captured location and provides novel insights into diverse spatially related biological contexts. Even though two databases exist, they provide limited analytical information. Information such as genes cells, cell-cell communication activities in space, cell type compositions...
The coronavirus disease of 2019 pandemic has catalyzed the rapid development mRNA vaccines, whereas, how to optimize sequence exogenous gene such as severe acute respiratory syndrome 2 spike fit human cells remains a critical challenge. A new algorithm, iDRO (integrated deep-learning-based optimization), is developed multiple components sequences based on given amino acid target protein. Considering biological constraints, we divided into two steps: open reading frame (ORF) optimization and...
The northeastern Hunan region in the Jiangnan Orogen (South China) is endowed with many important gold deposits, whose genesis remains controversial. Xiaojiashan a representative deposit (7.77 t Au @ 2.88 g/t) NE Hunan, and characterized by multi-stage pyrite formation. Its mineralization can be divided into 3 stages: (I) quartz-ankerite-pyrite-gold; (II) quartz-ankerite-polymetallic sulfide-gold; (III) quartz-ankerite stage. Three generations were identified: fine-grained porous Py1...
The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has resulted in loss of millions lives and severe global economic consequences. Every time SARS-CoV-2 replicates, viruses acquire new mutations their genomes. Mutations genomes led to increased transmissibility, disease outcomes, evasion immune response, changes clinical manifestations reducing efficacy vaccines or treatments. To date, multiple resources provide lists detected without key functional annotations. There is a lack...
Abstract Several groups of bacteria have complex life cycles involving cellular differentiation and multicellular structures. For example, actinobacteria the genus Streptomyces form vegetative hyphae, aerial spores. However, similar not yet been described for archaea. Here, we show that several haloarchaea family Halobacteriaceae display a cycle resembling bacteria. Strain YIM 93972 (isolated from salt marsh) undergoes into mycelia Other closely related strains are also able to mycelia,...
Abstract Heavy rare earth elements (HREE), as critical materials for the global transition to a low-carbon economy, are mostly supplied by regolith-hosted ion adsorption deposits formed from weathering of granites. Magmatic-hydrothermal titanite pronounced HREE enrichment in granites has been suggested play an important role forming HREE-dominated deposits. However, crystal-chemical mechanism and geological process responsible remain unknown. This study investigated two texturally distinct...
Widespread regolith cover makes it difficult to identify the anomalous size of their mineralogical or geochemical footprint at surface in gold exploration. Short wavelength infrared (SWIR) spectroscopy with effective identification clays and other hydrous minerals shows potential application The detailed geological short mapping was conducted newly-discovered orogenic-type Mailong deposit (13.06 t @ 6.29 g/t Au), East Kunlun, determine alteration stage mineral assemblages discuss values SWIR...
Fusarium species are among the most significant pathogens causing root rot in Panax notoginseng. In this study, a strain of Trichoderma hamatum was isolated from rhizosphere soil P. notoginseng and subjected to whole-genome sequencing. Plate confrontation experiments were conducted investigate antagonistic effects T. against oxysporum, solani, acutatum, primary rot. Whole-genome sequencing revealed 10,774 predicted genes hamatum, which 454 associated with carbohydrate-active enzymes...
The B115 strain, isolated from the inter-root soil of healthy plants in a continuous cropping site Panax notoginseng, was identified as Bacillus velezensis by 16S rDNA sequence comparison and comparative genomic analysis. is strain beneficial microorganisms present zone plants, with favorable plant growth-promoting properties antagonistic effects against pathogen Fusarium oxysporum. However, whole genome remains unclear, thus restricting its potential applications. To address this gap, has...
Regolith-hosted rare earth element (REE) deposits are common in South China. The newly-discovered Gucheng REE deposit the western part of Guangdong Province, is characterized by HREE enrichment (with ∑HREE oxides 55%). Three types granites have been identified ore district, a REE-fertile coarse-grained biotite granite (CGBG), weakly fine-grained (FGBG) and barren medium-grained (MGBG). New LA-ICP-MS zircon U-Pb dating reveals that MGBG (107.7 ± 0.4 Ma), CGBG (103.2 0.6 Ma) FGBG (98.9 0.7...
Antibodies play a pivotal role in immune defense and serve as key therapeutic agents. The process of affinity maturation, wherein antibodies evolve through somatic mutations to achieve heightened specificity target antigens, is crucial for effective response. Despite their significance, assessing antibody-antigen binding remains challenging due limitations conventional wet lab techniques. To address this, we introduce AntiFormer, graph-based large language model designed predict antibody...
Abstract Background Sexual differences across molecular levels profoundly impact cancer biology and outcomes. Patient gender significantly influences drug responses, with divergent reactions between men women to the same drugs. Despite databases on sex in human tissues, understanding regulations of disparities is limited. These resources lack detailed mechanistic studies sex-biased molecules. Methods In this study, we conducted a comprehensive examination distinctions regulatory networks 27...