A5028283484- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Cholinesterase and Neurodegenerative Diseases
- Nuclear Receptors and Signaling
- Lysosomal Storage Disorders Research
- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Receptor Mechanisms and Signaling
- Medicinal Plants and Neuroprotection
- Cannabis and Cannabinoid Research
- Cellular transport and secretion
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Natural product bioactivities and synthesis
- Regulation of Appetite and Obesity
- Computational Drug Discovery Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Chemical synthesis and alkaloids
- Flavonoids in Medical Research
- Pharmacological Effects of Natural Compounds
- Adipose Tissue and Metabolism
- Retinoids in leukemia and cellular processes
University of Macau
2018-2023
Quality Research
2023
China Pharmaceutical University
2016-2018
Abstract A reduced removal of dysfunctional mitochondria is common to aging and age-related neurodegenerative pathologies such as Alzheimer’s disease (AD). Strategies for treating impaired mitophagy would benefit from the identification modulators. Here we report combined use unsupervised machine learning (involving vector representations molecular structures, pharmacophore fingerprinting conformer fingerprinting) a cross-species approach screening experimental validation new...
NRBF2 is a component of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex. Our previous study has revealed its role in regulating ATG14-associated PtdIns3K activity for autophagosome initiation. In this study, we an unknown mechanism by which modulates maturation and APP-C-terminal fragment (CTF) degradation. data showed that localized at autolysosomes, loss impaired maturation. Mechanistically, colocalizes with RAB7 required generation GTP-bound interacting GEF CCZ1-MON1A...
Rationale: Impairment of autophagy maturation has been implicated in Alzheimer's disease (AD) pathogenesis.However, the mechanism for this impairment not elucidated, and whether enhancing is a viable therapeutic strategy AD verified.Methods: We examined autophagosome process cell mouse models by immunoblotting.To further understand changes brains, we analyzed transcriptome RNA-sequencing measured expression RAB7, CCZ1 MON1A.We performed brain stereotaxic injections AAV into 3xTg WT to...
Alzheimer's disease (AD) is a very common neurodegenerative disorder in the elderly and brings considerable financial social problems worldwide. In this study, polyprenols were firstly evaluated effects on cognitive deficits neuropathology APP/PS1 mice model of AD. At 3 months old, divided into group; low, middle, high dosage positive drug group. Age-matched wild-type chosen control The administration by oral gavage lasted 6 months. Polyprenols treatment significantly improved impairment...