A5001190903- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Exercise and Physiological Responses
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Marine and coastal ecosystems
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Liver Disease Diagnosis and Treatment
- Peatlands and Wetlands Ecology
- Endoplasmic Reticulum Stress and Disease
- Metabolomics and Mass Spectrometry Studies
- Ubiquitin and proteasome pathways
- Coastal wetland ecosystem dynamics
- Cancer-related molecular mechanisms research
- Atmospheric chemistry and aerosols
- Genetic and phenotypic traits in livestock
- Muscle metabolism and nutrition
- Caveolin-1 and cellular processes
- advanced mathematical theories
- Plant and Fungal Interactions Research
- Protein Tyrosine Phosphatases
- Electron Spin Resonance Studies
- Nutrition, Genetics, and Disease
- Theoretical and Computational Physics
East China Normal University
2009-2024
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2024
Chongqing Normal University
2023
University of Kentucky
2019
China Pharmaceutical University
2014
Jilin University
2014
Rivers and streams contribute significant quantities of methane (CH4) to the atmosphere. However, there is a lack CH4 flux ebullitive (bubble) emission data from urban rivers, which might lead large underestimations global aquatic emissions. Here, we conducted high-frequency surveys using boundary layer model (BLM) supplemented with floating chambers (FCs) bubble traps investigate seasonal diurnal variability in emissions eutrophic river evaluate whether contribution bubbles important. We...
Abstract N6‐methyladenosine (m 6 A) modification has been implicated in the progression of obesity and metabolic diseases. However, its impact on beige fat biology is not well understood. Here, via m A‐sequencing RNA‐sequencing, this work reports that upon adipocytes activation, glycolytic genes undergo major events A transcriptional activation. Genetic ablation writer Mettl3 tissues reveals deficiency mature leads to suppressed capability thermogenesis, as reduced preadipocytes...
Obesity is a complex chronic disease of high prevalence worldwide. Multiple factors play integral roles in obesity development, with rising interest focusing on the contribution environmental pollutants frequent modern society. Silver nanoparticles (AgNPs) are widely used for bactericidal purpose various applications daily life. However, their potential toxicity and to epidemic not clear.Beige adipocytes newly discovered characterized by thermogenic energy dissipating capacity upon...
Core Ideas We investigated estuarine environmental factors on CH 4 flux from two vegetation communities. Warming significantly affected emission the Phragmites australis community. There was a significant correlation between and water level in both Salinity affects emissions The interaction temperature most important factor controlling flux. Global warming, rising sea levels, saltwater intrusion interact to affect carbon cycling, specifically methane (CH ) coastal wetlands. In present study,...
Lysophosphatidic acids (LPAs) are bioactive radyl hydrocarbon-substituted derivatives of glycerol 3-phosphate. LPA metabolism and signaling implicated in heritable risk coronary artery disease. Genetic pharmacological inhibition these processes attenuate experimental atherosclerosis. accumulates atheromas, which may be a consequence association with LDLs. The source, regulation, biological activity LDL-associated unknown. We examined the effects hyperlipidemia on levels distribution...
SCP1 as a nuclear transcriptional regulator acts globally to silence neuronal genes and affect the dephosphorylation of RNA Pol ll. However, we report first finding description plasma membrane-localized protein in various cancer cells using EGFP- or other epitope-fused SCP1. Membrane-located dephosphorylates AKT at serine 473, leading abolishment 473 phosphorylation that results suppressed angiogenesis decreased risk tumorigenesis. Consistently, observed increased followed by enhanced...
Beige adipocytes are newly identified thermogenic-poised that could be activated by cold or β3-adrenergic receptor (β3-AR) signaling and offer therapeutic potential for treating obesity metabolic diseases. Here we applied RNA-sequencing analysis in the beige fat of mice under exposure β3-AR agonist CL316,243 (CL) treatment to provide a comparative comprehensive similarity heterogeneity these two stimulants. Importantly, via KEGG analysis, found CL commonly induced oxidative phosphorylation....
Resistance exercise leads to improved muscle function and metabolic homeostasis. Yet how circadian rhythm impacts outcomes its molecular transduction remains elusive.
Cholesterol metabolism is vital for multiple cancer progression, while how cholesterol affects lung, a low-cholesterol tissue, metastasis and the underlying mechanism remain unclear. In this study, we found that metastatic lung adenocarcinoma cells acquire cellular dehydrocholesterol by endogenous biosynthesis, instead of uptake upon treatment. Besides, demonstrated exogenous functions as signaling molecule to induce FOXA3, key transcription factor lipid via GLI2. Subsequently, ChIP-seq...
Background Ovarian stimulation (OS) for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) women with PCOS often results multiple follicular development, yet some individuals experience poor or suboptimal responses. Limited data exist regarding the impact of poor/suboptimal ovarian response on pregnancy outcomes PCOS. Objectives The aim this study was to evaluate whether live birth rate (LBR) per fresh embryo transfer and cumulative (CLBR) aspiration cycle differ defined by...
Beige fat, a newly discovered adipose tissue featuring high functional flexibility, exhibits the characteristics of white fat at rest, but can be activated to function like brown under cold or β-adrenergic stimulation via process termed 'browning fat'.This activation enables beige greatly promote heat production and energy consumption, as well improve systemic glucose lipid metabolism.Beige also exists in supraclavicular paraspinal regions human adults, which endows its great potential for...
Hepatic gluconeogenesis is critical for metabolic adaption in response to fasting, and its abnormal elevation contributes the pathogenesis of hyperglycemia type 2 diabetes. However, whether how protein hydroxylation regulates hepatic glucose metabolism remains largely unknown. Here we report that PHD3 identified as a fasting-induced factor through interaction CRTC2. Pro129 Pro615 CRTC2 following activation necessary nuclear translocation association with CREB, enhanced binding promoters...
The fungal species of <italic>Fusarium solani (F. solani) is closely associated with the soil borne root rot</italic> disease <italic>Panax ginseng,</italic> leading to quality decline in medicinal materials. In this study, we established experiment conditions two PCR-based microbiological assays, a droplet digital PCR(ddPCR) method and RT-qPCR method, tested their efficacy quick quantitative detection <italic>F. solani</italic> DNA ginseng soil. These methods were further evaluated...