A5101435443- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Facial Trauma and Fracture Management
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Liver Disease Diagnosis and Treatment
- Bone fractures and treatments
- Arsenic contamination and mitigation
- Environmental Toxicology and Ecotoxicology
- Hip and Femur Fractures
- Sirtuins and Resveratrol in Medicine
- Pneumonia and Respiratory Infections
- Hematological disorders and diagnostics
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Hematopoietic Stem Cell Transplantation
- Cancer-related molecular mechanisms research
- Botulinum Toxin and Related Neurological Disorders
- Antimicrobial Resistance in Staphylococcus
- Stress Responses and Cortisol
- Exercise and Physiological Responses
- Radiation Dose and Imaging
- Pain Management and Placebo Effect
- Metabolism, Diabetes, and Cancer
Air Force Medical University
2016-2025
Xijing Hospital
2025
Shanghai University
2024
Tianjin People's Hospital
2024
Tianjin Medical University
2024
Shanghai University of Traditional Chinese Medicine
2016-2024
Nankai University
2024
Shanghai Jiao Tong University
2022-2023
Shanghai Institute of Hematology
2022-2023
Tianjin Hospital
2011-2023
The dorsal medial prefrontal cortex (dmPFC) has been recognized as a key cortical area for nociceptive modulation. However, the underlying neural pathway and function of specific cell types remain largely unclear. Here, we show that lesions in dmPFC induced an algesic anxious state. Using multiple tracing methods including rabies-based transsynaptic method, outlined excitatory descending from to ventrolateral periaqueductal gray (vlPAG). Specific activation dmPFC/vlPAG by optogenetic...
As one of the thalamic midline nuclei, paraventricular nucleus (PVT) is considered to be an important signal integration site for many descending and ascending pathways that modulate a variety behaviors, including feeding, emotions, drug-seeking. A recent study has demonstrated PVT implicated in acute visceral pain response, but it unclear whether plays critical role central processing chronic pain. Here, we report neurons posterior portion (pPVT) their downstream pathway are involved...
Carbon tetrachloride (CCl4)-induced lipid peroxidation associated with hepatic oxidative stress and cell death is an important mechanism of acute liver injury (ALI). Ginsenoside Rd considered active ingredient ginseng. Evidence suggests that ginsenoside may improve ischaemic stroke, nerve damage, cancer other diseases involving apoptosis, inflammation, stress, mitochondrial autophagy. However, the effects on CCl4-induced ALI its underlying mechanisms are still unclear. In this study, 0.25%...
Bone cancer pain (BCP) severely compromises the quality of life, while current treatments are still unsatisfactory. Here, we tested antinociceptive effects triptolide (T10), a substance with considerable anti-tumor efficacies on BCP, and investigated underlying mechanisms targeting spinal dorsal horn (SDH). Intratibial inoculation Walker 256 mammary gland carcinoma cells was used to establish BCP model in rats. T10 intrathecally injected, mechanical allodynia by measuring paw withdrawal...
Arsenic (As) in the aquatic environment is a considerable environmental issue, previous studies have reported toxic effects of low concentrations (≤ 150 μg/L) As on fish. However, limited information available regarding impact levels apoptosis. To evaluate this, zebrafish embryos were exposed to different (0, 25, 50, 75, and (arsenite [AsIII] arsenate [AsV]) for 120 h. Our results indicated that AsIII exposure significantly inhibited survival larvae, increased transcription Caspase-9...
In rodents, the amygdala has been proposed to serve as a key center for nociceptive perception. Previous studies have shown that extracellular signal-regulated kinase (ERK) signaling cascade in central nucleus of (CeA) played functional role inflammation-induced peripheral hypersensitivity. Duloxetine (DUL), serotonin and noradrenaline reuptake inhibitor, produced analgesia on formalin-induced spontaneous pain behaviors. However, it is still unclear whether single DUL pretreatment influences...
Obesity is a complex chronic disease of high prevalence worldwide. Multiple factors play integral roles in obesity development, with rising interest focusing on the contribution environmental pollutants frequent modern society. Silver nanoparticles (AgNPs) are widely used for bactericidal purpose various applications daily life. However, their potential toxicity and to epidemic not clear.Beige adipocytes newly discovered characterized by thermogenic energy dissipating capacity upon...
Peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of adipocyte differentiation, glucolipid metabolism, and inflammation. Thiazolidinediones are PPARγ full agonists with potent insulin-sensitizing effects, whereas their oral usage restricted because unwanted side including obesity cardiovascular risks. Here, via virtual screening, microscale thermophoresis analysis, molecular confirmation, we demonstrate that diosmin, natural compound wide long-term clinical use,...
ABSTRACT A clinical isolate of Streptococcus pneumoniae (SP#5) that showed decreased susceptibility to evernimicin (MIC, 1.5 μg/ml) was investigated. 4,255-bp Eco RI fragment cloned from SP#5 identified by its ability transform evernimicin-susceptible S. R6 0.03 such the MIC μg/ml. Nucleotide sequence analysis this revealed it contained portions S10- spc ribosomal protein operons. The nucleotide sequences resistant and susceptible isolates were compared, a point mutation (thymine guanine)...
Abstract Lateral and ventral lateral subregions of the periaqueductal gray (l/vlPAG) have been proved to be pivotal components in descending circuitry itch processing, their effects are related subclassification neurons that were meditated. In this study, parabrachial nucleus (LPB), one most crucial relay stations ascending pathway, was taken as input examine modulatory effect l/vlPAG received LPB projections. Anatomical tracing, chemogenetic, optogenetic, local pharmacological approaches...
Abstract Background Mandibular fracture healing is a complex process involving nerves and growth factors. Nerve factor (NGF) not only facilitates the maintenance of sympathetic neurite but also stimulates other factors that can promote essential osteogenesis angiogenesis for healing. Therefore, it necessary to analyze combined effects NGF, bone morphogenic protein-9 (BMP-9), vascular endothelial (VEGF) accelerate mandible fractures. Methods The models with local nerve injury established in...
Anemarrhena asphodeloides is widely used for treatment of metabolic disorders in traditional Chinese medicine. This study investigated the effects total phenolic fraction on regulation insulin sensitivity adipocytes. Through with macrophage-derived conditioned medium, resistance was induced adipocytes IKKβ activation and dysregulation adipokine production. However, these changes were reversed by A. (1, 10, 50 µg/mL). It regulated serine/tyrosine phosphorylation receptor substrate-1...
Currently, there is a lack of validated pharmacological interventions for non-alcoholic fatty liver disease (NAFLD), which characterized by the accumulation hepatic triglyceride. Zhimu-Huangbai (ZH) herb-pair traditional Chinese medicine that regulates glucose and lipid metabolism disorders. However, precise mechanisms underlying preventive effects triglyceride induced high-fat diet (HFD) remain elusive.
Objective Intertrochanteric fracture is one type of hip fracture, which the most serious consequence osteoporosis. Along with growing elderly population, intertrochanteric expected to rise increasingly. The aim this study was assess excess mortality after fractures and identify predictors long‐term by therapy among patients aged 50 years older in Tianjin. Methods This a retrospective cohort on for 3029 Tianjin experiencing an between December 26, 2014 31, 2018. Data were from Hospital Hip...