A5100458284- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Microtubule and mitosis dynamics
- Wnt/β-catenin signaling in development and cancer
- Single-cell and spatial transcriptomics
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Retinal Imaging and Analysis
- Genomics, phytochemicals, and oxidative stress
- Retinal and Macular Surgery
- Parasitic infections in humans and animals
- Endoplasmic Reticulum Stress and Disease
- Retinoids in leukemia and cellular processes
- Natural product bioactivities and synthesis
- Occupational and environmental lung diseases
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Inflammasome and immune disorders
- Cancer Cells and Metastasis
- Renal and related cancers
- Spine and Intervertebral Disc Pathology
- Mitochondrial Function and Pathology
- Photoreceptor and optogenetics research
Hebei Medical University
2025
China Medical University
2018-2025
Northwest University
2025
Dalian Medical University
2016-2025
Sichuan University
2014-2025
Pingjin Hospital
2025
Hangzhou Normal University
2025
Wuhan Institute of Technology
2024
Yunnan Yingmao Biotechnology (China)
2024
Kunming University of Science and Technology
2020-2024
Abstract Skeletal muscle stem cells (MuSC), also called satellite cells, are indispensable for maintenance and regeneration of adult skeletal muscles. Yet, a comprehensive picture the regulatory events controlling fate MuSC is missing. Here, we determine proteome to design loss-of-function screen, identify 120 genes important function including arginine methyltransferase Prmt5. MuSC-specific inactivation Prmt5 in mice prevents expansion MuSC, abolishes long-term abrogates regeneration....
Patients with auto-brewery syndrome (ABS) become inebriated after the ingestion of an alcohol-free, high-carbohydrate diet. Our previous work has shown that high-alcohol-producing (HiAlc) Klebsiella pneumoniae can generate excessive endogenous ethanol and cause non-alcoholic fatty liver disease (NAFLD). Therefore, it is reasonable to speculate such bacteria might play important role in pathogenesis ABS.The characteristics metabolites intestinal flora from a clinical cohort patients ABS were...
For cancer treatment, collaborative strategies have been the mainstream for overcoming restrictions resulting from monotherapy. Combining chemotherapy with photodynamic therapy (PDT) has shown to increase antitumor effect and reduce side impacts. This study reports a hypoxia-activated prodrug BOD-Azo-single PDT agent aniline mustard connected by azo bond. With light illumination, exhibited some PDT. Under hypoxic conditions, bond cleaved released BOD-3-single of higher phototoxicity...
AIM:To investigate the role of overexpression B7-H3 in apoptosis colorectal cancer cell lines and underlying molecular mechanisms.METHODS: SW620 cells that highly overexpressed (SW620-B7-H3-EGFP) HCT8 stably transfected with shRNA (HCT8-shB7-H3) were previously constructed our laboratory.Cells pIRES2-EGFP used as negative controls (SW620-NC HCT8-NC).Real-time PCR western blotting analysis to detect mRNA protein expressions regulator proteins Bcl-2, Bcl-xl Bax.A proliferation assay was...
Photoreceptors, especially cones, which are enriched in the human macula, have high energy demands, making them vulnerable to metabolic stress. Metabolic dysfunction of photoreceptors and their supporting retinal pigment epithelium (RPE) is an important underlying cause degenerative diseases. However, how cones macula support exorbitant demand communicate with RPE unclear. By profiling metabolite uptake release analyzing genes, we found cone-rich retinas share specific features upregulated...
Increasing cell mobility is the basis of tumor invasion and metastasis, therefore a therapeutic target for preventing spread many types cancer. Septins are family cytoskeletal proteins with GTPase activity, play role in important cellular functions, including migration. SEPT9 isoform 1 protein (SEPT9_i1) has been associated breast development enhancement migration; however, exact mechanism how SEPT9_i1 might affect cancer progression remains to be elucidated. Here, we report that expression...
Abstract Liver fibrosis is characterized by excess reactive oxygen species (ROS) production, hepatic stellate cell (HSC) activation, and subsequent extracellular matrix deposition. Since complex pathways regulate HSC the single‐drug therapy efficacy for live often falls short of expectations. To address this issue, an HSC‐targeted multifunctional nanoparticle (NP) delivery system co‐loaded with cyclopamine (Cyc; hedgehog inhibitor) bilirubin (BR; ROS‐scavenger) designed. The NP, termed RHB,...
Heparan sulfate 3‐ O ‐sulfotransferase 2 (HS3ST2), an enzyme mediating ‐sulfation of heparan (HS), is silenced by hypermethylation in breast cancer. As HS has important co‐receptor function for numerous signal transduction pathways, the phenotypical changes due to HS3ST2 reexpression were investigated vitro using high and low invasive cancer cell lines. Compared controls, highly ‐expressing MDA‐MB‐231 cells showed enhanced Matrigel invasiveness, transendothelial migration motility....
Eukaryotic cells eliminate misfolded proteins from the endoplasmic reticulum (ER) via a conserved process termed ER-associated degradation (ERAD). Central regulators of ERAD system are membrane-bound ubiquitin ligases, which thought to channel through ER membrane during retrotranslocation. Hrd1 and gp78 mammalian ligases homologous Hrd1p, an ligase essential for in Saccharomyces cerevisiae. However, functional relevance these Hrd1p is unclear. In this paper, we characterize gp78-containing...
Cocaine abuse is a world-wide public health and social problem without US Food Drug Administration-approved medication. An ideal anticocaine medication would accelerate cocaine metabolism, producing biologically inactive metabolites by administration of an efficient cocaine-specific exogenous enzyme. Our recent studies have led to the discovery desirable, highly hydrolases (CocHs) that can efficiently detoxify inactivate affecting normal functions CNS. Preclinical clinical data demonstrated...
To compare functional and structural changes in the retina patients with aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD) multiple sclerosis (MS).Cross-sectional study; biochemical study of human retinas.A total 181 participants, including 22 consecutive (44 eyes) NMOSD, 131 (262 (MS), 28 normal subjects (56 eyes). In addition, 8 eyeballs from healthy donors were used for analysis.Full-field electroretinography (ERG) spectral-domain OCT...
Multiple sclerosis (MS), an autoimmune and degenerative disease, is characterized by demyelination chronic neuroinflammation. Bixin a carotenoid isolated from the seeds of
The human macula is more susceptible than the peripheral retina to developing blinding conditions such as age-related macular degeneration, diabetic retinopathy. A key difference between them may be nature of their Müller cells. We found primary cultured cells from and display significant morphological transcriptomic differences. Macular expressed phosphoglycerate dehydrogenase (PHGDH, a rate-limiting enzyme in serine synthesis) synthesis, glycolytic mitochondrial function were activated...