A5013379024- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Neuropeptides and Animal Physiology
- Photochromic and Fluorescence Chemistry
- Biochemical effects in animals
- Ophthalmology and Visual Impairment Studies
- Connexins and lens biology
- Retinoids in leukemia and cellular processes
- Glaucoma and retinal disorders
- Cancer, Hypoxia, and Metabolism
- Cellular transport and secretion
- Adipose Tissue and Metabolism
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Circadian rhythm and melatonin
- Retinal Imaging and Analysis
West Virginia University
2020-2024
Yangzhou University
2020-2024
Affiliated Hospital of North Sichuan Medical College
2020
North Sichuan Medical University
2019-2020
Suizhou Central Hospital
2019-2020
Jinan University
2019
University of Auckland
2013
Photoreceptors, especially cones, which are enriched in the human macula, have high energy demands, making them vulnerable to metabolic stress. Metabolic dysfunction of photoreceptors and their supporting retinal pigment epithelium (RPE) is an important underlying cause degenerative diseases. However, how cones macula support exorbitant demand communicate with RPE unclear. By profiling metabolite uptake release analyzing genes, we found cone-rich retinas share specific features upregulated...
Metabolic defects in the retinal pigment epithelium (RPE) underlie many degenerative diseases. This study aims to identify nutrient requirements of healthy and diseased human RPE cells.
The aim of this study is to investigate whether SOX2 gene variants were associated with high myopia in a Chinese population.This conducted using case-control association analysis. This recruited 83 healthy controls (with binocular spherical equivalent between -0.50 and +0.50 D) 117 cases (spherical > -6.00 D both eyes). Three single-nucleotide polymorphisms selected from HapMap database for genotyping by direct sequencing. Statistical software (SPSS 22.0) was used statistical chi-square test...
The present study compared the expression of brain-derived neurotrophic factor (BDNF) in lateral geniculate body between form deprivation amblyopia kittens and normal to examine significance BDNF pathogenesis amblyopia.Twenty were divided into control group (n = 10) 10). A black opaque eye mask was placed cover right group. Pattern visual-evoked potentials (PVEPs) detected weekly all .After developed monocular amblyopia, bodies removed. two groups by immunohistochemistry Western blotting.The...
Abstract Background Retinitis pigmentosa (RP) is one of the major types hereditary retinal dystrophies with extreme genotypic heterogeneity. To date, more than 80 genes have been identified to be associated RP in human. Method Here, we presented a clinical genetic study three Chinese man manifested night vision blindness and complete loss midperipheral visual field. All these probands both central far peripheral Gradual rod cells followed by subsequent cone probands. Targeted next generation...
Abstract Purpose Metabolic defects in the retinal pigment epithelium (RPE) underlie many degenerative diseases. This study aims to identify nutrient requirements of healthy and diseased human RPE cells. Methods We profiled utilization various cells, including differentiated dedifferentiated fetal (fRPE), induced pluripotent stem cell derived-RPE (iPSC RPE), Sorsby fundus dystrophy (SFD) patient-derived iPSC RPE, CRISPR-corrected isogenic SFD (cSFD) ARPE-19 lines using Biolog Phenotype...
Abstract Background: Exploring the role of vasoactive intestinal peptide (VIP) in lateral geniculate body (LGBd) visual development and studying therapeutic effect VIP on amblyopic kittens. Methods: Three-week-old domestic cats were divided into a control group (n = 10) monocular deprivation 20), with an eye mask covering right those deprived group. After pattern evoked potential (PVEP) recording confirmed formation amblyopia, left LGBd was isolated from 5 kittens each The remaining...
Abstract Background : Exploring the role of vasoactive intestinal peptide (VIP) in lateral geniculate body (LGBd) visual development and studying therapeutic effect VIP on amblyopic kittens. Methods: Three-week-old domestic cats were divided into a control group (n = 10) monocular deprivation 20), with an eye mask covering right those deprived group. After pattern evoked potential (PVEP) recording confirmed formation amblyopia, left LGBd was isolated from 5 kittens each The remaining...
Abstract Background Exploring the role of vasoactive intestinal peptide (VIP) in lateral geniculate body (LGBd) visual development and studying therapeutic effect VIP on amblyopic kittens. Methods Three-week-old domestic cats were divided into a control group (n = 10) monocular deprivation 20), with an eye mask covering right those deprived group. After pattern evoked potential (PVEP) recording confirmed formation amblyopia, left LGBd was isolated from 5 kittens each The remaining continued...