A5100703302- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- dental development and anomalies
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Periodontal Regeneration and Treatments
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Neuropeptides and Animal Physiology
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- DNA Repair Mechanisms
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- Cleft Lip and Palate Research
- Photochromic and Fluorescence Chemistry
- Hippo pathway signaling and YAP/TAZ
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
Guangxi Normal University
2025
Chinese Academy of Sciences
2012-2025
University at Buffalo, State University of New York
2024-2025
Cancer Hospital of Chinese Academy of Medical Sciences
2021-2025
Zhejiang Cancer Hospital
2019-2025
UPMC Hillman Cancer Center
2015-2024
Tulane University
2019-2024
Northwest University
2010-2022
University of Pittsburgh
2015-2021
University of Pittsburgh Medical Center
2018-2021
<title>Abstract</title> Therapeutic strategies for peritoneal metastasis in solid tumors are urgently needed the clinic. Programming chimeric antigen receptor macrophages (CAR-Ms) <italic>in situ</italic> offers opportunities an unmet demand. However, potential intracellular domains (ICDs) CAR design and their antitumor mechanisms macrophage empowerment remain to be explored systematically. By developing a targeted mRNA-LNP delivery system macrophages, we have investigated 36 combinations...
Recent studies suggest that high expression of the proinflammatory cytokine IL6 is associated with poor survival lung cancer patients. Accordingly, has been a target great interest for therapy. However, role in not determined yet. Here, we demonstrate plays opposite roles initiation and growth mouse model induced by K-Ras oncogene. We find compared wild-type mice, IL6-deficient mice developed much more tumors after an activating mutant was lungs. were significantly smaller. Notably, both...
Abstract Venous hypertension(VH) plays an important role in the pathogenesis of cerebral arteriovenous malformations (AVMs) and is closely associated with HIF-1α/VEGF signaling pathway. Nuclear factor erythroid 2-related 2(Nrf2) significantly influences angiogenesis; however, interplay between Nrf2 VEGF under VH brain AVMs remains unclear. Therefore, our study aimed to investigate due AVMs. Immunohistochemistry indicated that were highly expressed human AVM tissues. In vivo , we established...
One of the most fundamental and challenging questions in cancer field is how immunity patients with transformed from tumor immunosurveillance to tumor-promoting inflammation. Here, we identify transcription factor STAT3 as culprit responsible for this pathogenic event lung development. We found that antitumor type 1 CD4+ T-helper (Th1) cells CD8+ T were directly counter balanced development myeloid-derived suppressor (MDSCs) suppressive macrophages, activation MDSCs macrophages promoted...
Statement of RetractionWe, the Editors and Publisher journal Cell Cycle, have retracted following article:Danhua Zhang, Xinguang Qiu, Jianhua Li, Shouhua Zheng, Liwen Hongchao Zhao. TGF-β secreted by tumor-associated macrophages promotes proliferation invasion colorectal cancer via miR-34a-VEGF axis. Cycle. 2018;17(24):2766-2778, doi:10.1080/15384101.2018.1556064.Since publication, concerns been raised about integrity data in article. When approached for an explanation, authors unable to...
Abstract The Ataxia-telangiectasia-mutated (ATM) gene product is a well-characterized tumor suppressor that plays key role in maintenance of genomic stability. We have recently documented the ATM promoter target for epigenetic silencing cultured cells. Here we show aberrant methylation occurs significant percentage (25%) head and neck squamous cell carcinomas. presence methylated shows statistically correlation with an earlier age initial diagnosis decreased overall survival, particularly...
Tachycardia-induced atrial fibrosis is a hallmark of the structural remodeling fibrillation (AF). The mechanisms underlying tachycardia-induced remain unclear. In our previous study, we found that Smad7-downregulation promoted development in AF. Fibroblasts are enriched microRNA-21 (miR-21), which contributes to and heart failure cardiovascular system. Our study was designed test hypothesis miR-21 reinforces TGF-β1/Smad signaling pathway AF-induced by down-regulating Smad7. Rapid pacing...
Evidences indicate that inflammatory process plays pivotal role in tumor disease. Soluble epoxide hydrolase inhibitors (sEHIs) have been shown to participate anti-inflammation and tumorigenesis by protecting epoxyeicosatrienoic acids (EETs). Although we previously revealed some effects of t-AUCB on glioma vitro, further investigations are needed demonstrate its glioblastoma growth vivo how strengthen antitumor effect. CCK-8 kit was used test cell growth. Cell migration capacity performed...
Activation of the inflammatory transcription factor NF-κB in tumor-associated macrophages (TAMs) is assumed to contribute tumor promotion. However, whether and how drives antitumor become pro-tumorigenic have not been determined any cancer type yet. Similarly, TAMs repress CD8+ cytotoxic T lymphocytes (CTLs) remains largely unknown, although their importance regulatory (Treg) cell regulation promotion has well appreciated. Here, using an endogenous lung model we uncover a direct crosstalk...
Most cancers are resistant to anti-PD-1/PD-L1 and chemotherapy. Herein we identify PDLIM2 as a tumor suppressor particularly important for lung cancer therapeutic responses. While is epigenetically repressed in human cancer, associating with resistance poor prognosis, its global or epithelial-specific deletion mice causes increased development, chemoresistance, complete anti-PD-1 epigenetic drugs. restoration ectopic expression shows antitumor activity, synergizes anti-PD-1, notably,...
Tooth enamel, the hardest tissue in vertebrates, is crucial for mastication and dental protection. Its formation depends on enamel organ (EO), a specialized epithelial structure derived from oral epithelium. A fundamental question persists: how does uniform epithelium differentiate into diverse EO cell types? While p63, master regulator of ectodermal development, coordinates multiple signaling pathways essential placode formation, its specific roles development remain unclear due to early...
Abstract Premise A karst tiankeng, a unique sinkhole‐like terrain with rare and distinctive habitat, is often likened to an isolated island because of its limited contact the external environment. This landscape potentially shapes evolution distribution associated plant species. However, relative contributions environmental impacts versus phylogenetic relationships in shaping adaptations tiankeng environment remain unclear. We analyzed trait divergence within Laureae, dominant group forest,...
Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against stress involves repair. One of the primary repair mechanisms for is base excision (BER). BER tightly coordinated function four enzymes (glycosylase, apurinic/apyrimidinic endonuclease, polymerase and ligase), in which 8-oxoguanine glycosylase 1 initiates cycle. imbalance production any one these may result generation more increased cell killing. In this study,...
Immunoglobulin-like transcript 4 (ILT4) is an inhibitory molecule involved in immune response and has recently been identified to be strongly inducible by IL-10. The aim of the present study was examine associations ILT4 expression with clinicopathological characteristics IL-10 primary ductal lobular breast cancer. We studied cancer cell lines, 117 tumor tissues 97 metastatic lymph nodes from patients reverse transcription-polymerase chain reaction, western blot or immunohistochemistry...
One of the most fundamental and challenging questions in field cancer is how immunity transformed from tumor immunosurveillance to tumor-promoting inflammation. Here, we identified suppressor PDZ-LIM domain–containing protein 2 (PDLIM2) as a checkpoint alveolar macrophages (AMs) important for lung suppression. During tumorigenesis, PDLIM2 expression AMs downregulated by ROS-activated transcription repressor BTB CNC homology 1 (BACH1). downregulation leads constitutive activation factor...
This study aims to investigate the mechanism of miR-23a-3p in regulating Treg dysfunction Graves' disease (GD). The percentage cells and interleukin (IL)-17+ T were determined by flow cytometry. expression forkhead box P3 (FOXP3), sirtuin 1 (SIRT1), RAR-related orphan receptor gamma t (RORγt) was analyzed quantitative reverse transcription polymerase chain reaction (qRT-PCR) or Western blot. CD4+ treated with SIRT1 specific inhibitor EX-527 left untreated. MiR-23a-3p mimic transfected into...