A5044625555- dental development and anomalies
- Bone and Dental Protein Studies
- Oral and Maxillofacial Pathology
- Endodontics and Root Canal Treatments
- Dental Trauma and Treatments
- Oral microbiology and periodontitis research
- Mesenchymal stem cell research
- Connexins and lens biology
- Periodontal Regeneration and Treatments
- Dental Radiography and Imaging
- Heat shock proteins research
- Sulfur Compounds in Biology
- Cancer-related gene regulation
- Laser Applications in Dentistry and Medicine
- Dental materials and restorations
- Salivary Gland Disorders and Functions
- Dental Implant Techniques and Outcomes
- Immune Response and Inflammation
- Cleft Lip and Palate Research
- Bone Tissue Engineering Materials
- Proteoglycans and glycosaminoglycans research
- Orthodontics and Dentofacial Orthopedics
- Immunotherapy and Immune Responses
- Bone health and treatments
- T-cell and B-cell Immunology
Niigata University
2016-2025
Kanazawa University
2025
Takenaka (Japan)
2022
John Wiley & Sons (United States)
2016
Hudson Institute
2016
Niigata University Medical and Dental Hospital
2001-2012
Kagoshima University
2011
Nihon University
2009
University of Shizuoka
2006
Centre International de Recherche sur le Cancer
1986-2006
Mouse, rat and human molars begin to form root after the completion of crown formation. In these teeth, fibroblast growth factor (Fgf) 10 disappears in transitional stage from formation root. By contrast, rodent incisors vole demonstrate continuous growth, owing maintenance a stem cell compartment by constant expression Fgf10. To clarify relationship between disappearance Fgf10, we carried out two experiments for loss gain Fgf10 function. First, examined postnatal Fgf10-deficient mice, which...
Abstract On the basis of anthropological pilot studies on diet in Tunisia, south China and Greenland, food items consumed frequently by these populations at high risk for NPC were analysed volatile nitrosamines using gas chromatography combined with a thermal energy analyzer. Relatively levels N‐nitrosodimethylamine (NDMA), N‐nitrosopyrrolidine (NPYR) N‐nitrosopiperidine (NPIP) detected Tunisian stewing base (“Touklia”) dried mutton preserved olive oil (“Qaddid”). NDMA was also ranging from...
Osteopontin (OPN) is a highly phosphorylated glycoprotein that prominent component of the mineralized extracellular matrix bone. The secretion OPN by immunocompetent cells plays role in differentiation odontoblast-like during pulpal healing following tooth transplantation. This study aimed to clarify reparative dentinogenesis. A groove-shaped cavity was prepared on mesial surface upper first molars wild-type (WT) and Opn knockout (KO) mice, samples were collected at intervals 1 14 d....
Differentiated odontoblasts could not be identified by one unique phenotypic marker, but the combination of expression dentin phosphoprotein (Dpp), sialoprotein (Dsp), matrix protein 1 (Dmp1), and nestin may valuable for assessment these cells. However, findings using proteins remain controversial. This study aimed to compare two odontoblast differentiation markers: Dsp in process dentinogenesis mice. We performed immunohistochemistry and/or situ hybridization technique 3-week-old incisors...
Control of plaque and debris is essential for the prevention inflammatory periodontal diseases dental caries, because primary etiological factor in introduction development both these infection-oriented diseases. Plaque removal with a toothbrush most frequently used method oral hygiene. Powered toothbrushes were developed beginning 1960s are now widely countries. The bristles should be able to reach clean efficiently areas mouth, recently design manual powered has focused on ability...
Abstract Mesenchymal stromal cells (MSCs) differentiation into different lineages is precisely controlled by signaling pathways. Given that protein kinases play a crucial role in signal transduction, here we show Microtubule Associated Serine/Threonine Kinase Family Member 4 (Mast4) serves as an important mediator of TGF-β and Wnt transduction regulating chondro-osteogenic MSCs. Suppression Mast4 TGF-β1 led to increased Sox9 stability blocking Mast4-induced serine 494 phosphorylation...
The detailed mechanism of osseointegration, the most appropriate implant-bone interface, remains unclear in jaw tissues at ultrastructural level contrast to many reports using long bones. present study on tissue response titanium-implantation an animal model rat maxilla.Animals were sacrificed 1 28 days post-implantation and prepared specimens, freed from implants by a cryofracture technique, processed for transmission electron microscopy histochemistry tartrate resistant acid phosphatase...
It is well known that a number of head and neck carcinomas are associated with HRAS mutations, several cancers RAS such as lung cancer, have poor prognosis. In this study, we evaluated the frequency mutations in characterized clinical cell biological features mutations. at codons 12, 13, 61, mutational hot spots, were tissue specimens obtained from 119 Japanese patients treated our institution. DNA was successfully extracted 100 specimens, sequencing completed. An mutation found 8 (8.0%)...
Conventional head and neck practice procedures fail to address several clinical issues. Anatomical structures were removed from the surface layers in that order, dissection was shifted deeper layer. This approach makes it difficult for medical dental students understand relationships among various anatomical structures. Furthermore, is determine risk on mandibular nerves blood vessels during conventional mandible removal procedures. study aims develop an technique maintains skin, superficial...
Responses of odontoblasts and pulp capillaries to cavity preparation were investigated in the upper first molar teeth rats, using light transmission electron microscopy. At 100 days age, blood vessels formed a subodontoblastic network consisting continuous at short distance from odontoblast layer. Cavity caused displacement some into dentinal tubules, while others separated predentin by rapid inflammatory exudation after drilling. The capillary under injured dentin was shifted inwards...