A5039990488- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Pluripotent Stem Cells Research
- Ocular Diseases and Behçet’s Syndrome
- Mesenchymal stem cell research
- Retinopathy of Prematurity Studies
- Fish Ecology and Management Studies
- Vascular Malformations Diagnosis and Treatment
- Ophthalmology and Visual Impairment Studies
- Synthesis and properties of polymers
- Thermal properties of materials
- 3D Printing in Biomedical Research
- Polymer Nanocomposites and Properties
- Marine and fisheries research
- Renal and related cancers
- Mechanical Engineering and Vibrations Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Polymer crystallization and properties
- CRISPR and Genetic Engineering
- Optical Imaging and Spectroscopy Techniques
- Neonatal Respiratory Health Research
University of Tsukuba
2016-2025
Asahi University
2022-2024
Japan Clinical Cancer Research Organization
2023
Mizuho (Japan)
2022
National Hospital Organization Mito Medical Center
2021
Tsukuba University of Technology
2021
Tokyo University of Agriculture and Technology
2021
Muroran Institute of Technology
2021
Kindai University
2019-2020
Niigata University
2013-2019
Control of plaque and debris is essential for the prevention inflammatory periodontal diseases dental caries, because primary etiological factor in introduction development both these infection-oriented diseases. Plaque removal with a toothbrush most frequently used method oral hygiene. Powered toothbrushes were developed beginning 1960s are now widely countries. The bristles should be able to reach clean efficiently areas mouth, recently design manual powered has focused on ability...
The effects of the ultra-high-molecular-weight (UHMW) component polypropylene (PP) on its rheological properties, crystallization behavior, and solid-state mechanical properties were investigated using various measurement techniques. terminal relaxation time-determined by measuring linear viscoelasticity-was increased adding UHMW component. increase in melt elasticity produced was observed steady-state shear flow, although viscosity not greatly affected. Owing to long characteristic time...
To investigate changes in metamorphopsia after rhegmatogenous retinal detachment surgery and to evaluate the relationship between microstructures assessed with optical coherence tomography.The study included 47 eyes of patients undergoing surgery. We examined severity using M-CHARTS, best-corrected visual acuity, tomography images. All data were recorded before 3, 6, 12 months surgery, except for M-CHARTS which only postoperatively.Metamorphopsia scores at postoperatively 0.46 ± 0.51, 0.41...
Abstract Intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) is the standard treatment modality in various types retinal diseases. However, endophthalmitis remains most serious complication. Despite lack evidence that antibiotics prevent endophthalmitis, topical are still used routinely Japan. We conducted a retrospective multicenter study by analyzing records from patients who underwent IVI anti-VEGF agents with or without antibiotic treatment. In analysis total...
Background/Objectives: We sought to assess the relationship between contrast sensitivity (CS) and optical coherence tomography (OCT) findings, including ganglion cell–inner plexiform layer (GCIPL) thickness, in eyes with cystoid macular edema, secondary branch retinal vein occlusion (BRVO-CME), treated intravitreal ranibizumab (IVR). Methods: This prospective study included 44 patients BRVO-CME who underwent treatment IVR (three monthly injections pro re nata) were followed up for 12 months....
Background: Bacterial endophthalmitis is a rare but serious complication of intravitreal injections (IVIs). Prefilled syringes have been introduced to reduce contamination risk during drug preparation. However, whether they lower the incidence bacterial compared vials remains unclear. Methods: This retrospective cohort study analyzed aflibercept IVIs performed at 17 clinical centers in Japan between 2015 and 2022. Patients aged ≥20 years who received (vial or prefilled syringe) for...
Purpose To investigate the clinical features, treatment options, and visual outcomes of submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (nAMD). Design A retrospective, observational case series. Methods Setting: Multicenter institutional setting. Patient Population: total 127 patients (127 eyes; 88 men, 39 women; (mean age, 74.2 years)) diagnosed with AMD-associated SMHs exceeding 2 disc diameters involving fovea. Observation: The AMD types, previous...
The effects of some important factors on the blood glucose measurements by NIR spectroscopy are investigated numerical simulation, and a method is proposed to significantly reduce prediction errors induced these effects. changes in absorbance spectra with concentration, temperature scattering characteristics background tissue obtained Monte Carlo simulation light propagation for wavelength range from 1200 nm 1800 nm. concentration predicted applying multivariate analysis numerically...
The ability of human deciduous tooth dental pulp cells (HDDPCs) to differentiate into odontoblasts that generate mineralized tissue holds immense potential for therapeutic use in the field regenerative medicine. Realization this depends on efficient and optimized protocols genetic manipulation HDDPCs. In study, we demonstrate a PiggyBac (PB)-based gene transfer system as method introducing nonviral transposon DNA HDDPCs HDDPC-derived inducible pluripotent stem cells. transfection efficiency...
Novel composite films exhibiting high thermal conductivity along the out-of-plane direction were prepared from two types of immiscible polyimides (PIs) and needle-shaped ZnO particles.
The aim of the present study was to prove that primary cells enriched with stem are more easily reprogrammed generate induced pluripotent (iPS) than those scarce numbers cells.We surveyed alkaline phosphatase (ALP) activity in five primarily-isolated human deciduous teeth-derived dental pulp (HDDPC) cytochemical staining examine possible presence cells. Next, expression stemness-specific factors, such as OCT(Octumer-binding transcription factor)3/4, NANOG, SOX2(SRY (sex determining region...
Abstract This study investigated the changes in severity of aniseikonia after surgery for macula-off retinal detachment (RD), and relationship between microstructures. The included 26 eyes patients undergoing RD surgery. Visual acuity was measured preoperatively, at 3, 6, 12 months postoperatively. Degree OCT images were obtained values (mean ± standard deviation) postoperatively −5.3 4.2%, −4.4 4.4%, −3.1 3.2%, respectively. Significant improvement observed from 3 to ( P = 0.001). Twelve...
ABSTRACT Aims/Introduction To conduct a multicenter survey of visually impaired patients with diabetes mellitus (DM) and to identify the physical ocular characteristics that lead blindness in Japan. Materials Methods Visually Japan were divided into blind low‐vision groups according World Health Organization classification. Data on parameters related complications right left eyes collected from 19 highly advanced medical facilities compared between two groups. Results Among 408 persons...
Type 1 diabetes occurs due to the autoimmune destruction of pancreatic β-cells in islets. Transplantation islets is a promising option for treatment patients with type that experience hypoglycemic unawareness despite maximal care, but present shortage donor hampers such transplantation. insulin-producing cells derived from themselves would be one most approaches cure diabetes. Previously, we demonstrated could produced by transfecting murine Yamanaka's reprogramming factors. Non-obese...
Abstract Human tissue-specific stem cells (hTSCs), found throughout the body, can differentiate into several lineages under appropriate conditions in vitro and vivo . By transfecting terminally differentiated with reprogramming factors, we previously produced induced TSCs from pancreas hepatocytes that exhibit additional properties than iPSCs, as exemplified by very low tumour formation after xenogenic transplantation. We hypothesised hTSCs, being partially reprogrammed a state just prior to...
Stage-specific embryonic antigen 1 (SSEA-1) is an antigenic epitope (also called CD15 antigen) defined as a Lewis X carbohydrate structure and known to be expressed in murine embryonal carcinoma cells, mouse stem cells (ESCs), human germ but not ESCs/induced pluripotent (iPSCs). It produced by α1,3-fucosyltransferase IX gene (FUT9), F9 ECCs having disrupted FUT9 locus targeting are reported exhibit loss of SSEA-1 expression on their cell surface. Mouse ESCs therefore "naïve (NSCs)." In...
Feeder cells are generally required to maintain embryonic stem (ESCs)/induced pluripotent (iPSCs). Mouse fibroblasts (MEFs) isolated from fetuses and STO mouse stromal cell line the most widely used feeder cells. The aim of this study was determine which suitable for establishing iPSCs human deciduous tooth dental pulp (HDDPCs). Primary cultures HDDPCs were cotransfected with three plasmids containing OCT3/4, SOX2/KLF4, or LMYC/LIN28 pmaxGFP by using a novel electroporation method, then...