A5012578042- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Infection Control and Ventilation
- Ocular Diseases and Behçet’s Syndrome
- Traumatic Ocular and Foreign Body Injuries
- Dental Research and COVID-19
- Ocular Surface and Contact Lens
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Genomics and Rare Diseases
- Childhood Cancer Survivors' Quality of Life
- Corneal surgery and disorders
- Drug-Induced Ocular Toxicity
- Photovoltaic Systems and Sustainability
- Fetal and Pediatric Neurological Disorders
- Hybrid Renewable Energy Systems
- Craniofacial Disorders and Treatments
- Renewable energy and sustainable power systems
- Folate and B Vitamins Research
- Cancer Genomics and Diagnostics
University of Fukui
2017-2025
Japan Clinical Cancer Research Organization
2024
University of Fukui Hospital
2018
Environmental Protection Engineering (Greece)
2007
Harbin Electric Corporation (China)
2007
Hakodate National Hospital
1988-1996
Microaneurysm (MA) plays an important role in the pathogenesis of diabetic macular edema (DME) progression and response to anti-vascular endothelial growth factor (VEGF) therapy. This study aimed investigate effect faricimab, a bispecific antibody against angiopoietin-2 VEGF, on number MAs their turnover treatment DME.We included that patients with DME who underwent three monthly injections faricimab one eye, other eye as control. We examined central retinal thickness (CRT) based optical...
This retrospective observational multicentre cohort study compared the rate of postoperative cystoid macular oedema (CME) between two intraocular lens (IOL) scleral fixation (SFIOL) techniques: a flanged IOL technique (Yamane technique) and suture transscleral (conventional technique). The included 207 eyes with CME that had undergone SFIOL were observed for > 12 weeks January 2019 2021. primary endpoint was comparison at 3 months groups. Secondary endpoints best-corrected visual acuity...
Abstract Diabetic nephropathy and retinopathy (DR) including diabetic macular edema (DME) are representative microvascular complications of diabetes. We conducted a retrospective multicenter study analyzing records from patients with DR (132 eyes in 70 patients) end-stage renal diseases (ESRD) who underwent hemodialysis for the first time. demonstrated that central retinal thickness (CRT) values were significantly decreased (p < 0.0001), best-corrected visual acuity (BCVA) improved 0.05)...
ABSTRACT Aims/Introduction To conduct a multicenter survey of visually impaired patients with diabetes mellitus (DM) and to identify the physical ocular characteristics that lead blindness in Japan. Materials Methods Visually Japan were divided into blind low‐vision groups according World Health Organization classification. Data on parameters related complications right left eyes collected from 19 highly advanced medical facilities compared between two groups. Results Among 408 persons...
The purpose of this study was to evaluate whether photocoagulation the retinal nonperfusion area suppresses ocular vascular endothelial growth factor (VEGF) expression in a rabbit vein occlusion (RVO) model.The retinas pigmented rabbits were made ischemic by laser on main branch veins following intravenous injection Rose Bengal. eyes enucleated before treatment and at 1, 7, 14 days after occlusion. VEGF protein levels vitreous humor, sensory retina, pigment epithelium-choroid measured with...
Background and Objectives: The presence of refractory cases resistant to anti-vascular endothelial growth factor (VEGF) therapy for diabetic macular edema (DME) is a problem in clinical practice. This study aimed explore the less responsive area optical coherence tomography (OCT) 3D map characteristics naïve DME after their first anti-VEGF. Materials Methods: In 46 patients with who received an intravitreal injection anti-VEGF agents, retinal thickness 100 sections was measured by 3D-mapping...
We report on a sporadic case of heterotaxia with de novo chromosome structural abnormality. The patient had inversely located heart (dextrocardia), stomach, duodenum, and cecum. In addition, she cerebral atrophy, hypertelorism telecanthus, infraorbital skin furrows, ear-lobe grooves, prominent maxilla teeth, large carp mouth, short fifth fingers limited flexion, generalized hypotonicity, severe psychomotor retardation. High-resolution banding analysis demonstrated an apparently balanced...
Abstract Purpose To investigate the relationship between microaneurysm (MA) density and residual oedema after intravitreal injection of an anti‐vascular endothelial growth factor agent for treatment diabetic macular (DMO). Methods Patients with DMO were divided into those (RO) no (NRO) by presence absence at 1 month either aflibercept or ranibizumab. We then compared MA density, best corrected visual acuity (BCVA), central retinal thickness (CRT) size severely thickened area, as indicated a...
Abstract Childhood maltreatment is reportedly associated with atypical gray matter structures in the primary visual cortex (V1). This study explores hypothesis that retinal structures, sensory organs of vision, are brain atypicality and child examines their interrelation. General ophthalmologic examinations, cognitive tasks, imaging, structural magnetic resonance imaging (MRI) were conducted children adolescents aged 9–18 years experiences (CM) typically developing (TD) children. The nerve...
Macular edema is a known side effect of taxane-based anticancer drugs. We retrospectively investigated data from 11 centers between January 2016 and December 2021. Among 14,260 patients, 30 (0.21%) developed macular edema; these, the number cases associated with nab-paclitaxel was 16 (0.43%), significantly higher than paclitaxel or docetaxel (P < 0.01). Visual acuity (VA) retinal choroidal change were examined in 27 follow-up at least 3 months. The patients' mean age 67.2 years; 14 (51.3%)...
Purpose: To evaluate the concentrations of brimonidine and brinzolamide in vitreous aqueous humor after instillation a 0.1% tartrate 1% fixed-combination ophthalmic suspension. Methods: The present investigation involved patients with macular holes or idiopathic epiretinal membranes who were planning to undergo vitrectomy. One week prior surgery, received twice-daily topical treatment Before vitrectomy, samples collected, mean determined through liquid chromatography-tandem spectrometry....
Purpose To evaluate the concentrations of brimonidine and timolol in vitreous aqueous humors after instillation a 0.1% tartrate 0.5% fixed-combination ophthalmic solution. Methods This single-arm open-label interventional study included patients with macular holes or idiopathic epiretinal membranes who were scheduled for vitrectomy. Written informed consent was obtained from all participants. A solution administered topically twice daily 1 week preoperatively. The sampled before vitrectomy,...
We aimed to evaluate the effect of topical application a strong corticosteroid, difluprednate, on levels inflammatory and angiogenic cytokine in vitreous aqueous humor after laser photocoagulation.Pigmented rabbits were treated with retinal photocoagulation divided into 4 groups, namely control (no additional treatment), difluprednate 0.05%, betamethasone sodium phosphate 0.1%, sub-Tenon injection triamcinolone acetonide (STTA). Samples collected posttreatment days 0, 1, 7, 14. The...
Diabetic macular edema (DME) induces visual disturbance, and intravitreal injections of anti-vascular endothelial growth factor (VEGF) drugs are the accepted first-line treatment. We investigate its impact on glycemic control after starting VEGF treatment for DME basis a questionnaire changes in hemoglobin A1c (HbA1c). conducted retrospective multicenter study analyzing 112 patients with who underwent anti-VEGF therapy their HbA1c over two years. Central retinal thickness acuity...
Abstract Purpose This study aimed to evaluate anterior flare intensity (AFI) after intravitreal injection of brolucizumab (IVBr) in patients with diabetic macular edema (DME), and identify the factors associated change AFI IVBr. Methods prospective multicenter was conducted at five sites Japan for DME who underwent a single central retinal thickness (CRT) were measured using laser meter spectral-domain optical coherence tomography, respectively, weeks 0 6. Results Sixty-five (phakia, 37...
Background/Objectives: Microaneurysms (MAs) are important in the pathology of diabetic macular edema (DME) and its response to anti-vascular endothelial growth factor (VEGF) therapy. This study aimed clarify morphological characteristics MAs residual following consecutive faricimab injections, a bispecific antibody against angiopoietin-2 VEGF. Methods: We selected patients with DME who exhibited after three monthly injections faricimab. In both absorbed areas edema, we counted turnover MAs,...
Background: Pro re nata (PRN) regimen using anti-vascular endothelial growth factor (VEGF) agent is popular for the treatment of diabetic macular edema (DME). We investigated influence waiting time (WT) and interval between date recurrence re-injection on efficacy. Methods: This retrospective study conducted at 7 sites in Japan enrolled patients who received intravitreal injection ranibizumab (IVR) aflibercept (IVA) 1+PRN regimen. Enrolled were divided into 2 groups: prompt group (less than...
<title>Abstract</title> This retrospective observational multicentre cohort study compared the rate of postoperative cystoid macular oedema (CME) between two intraocular lens (IOL) scleral fixation techniques: a flanged IOL technique (Yamane technique) and suture transscleral (conventional technique). The included 207 eyes with CME that had undergone were observed for > 12 weeks January 2019 2021. primary endpoint was comparison at 3 months groups. Secondary endpoints best-corrected...
To compare the intraocular pressure (IOP) after an intravitreal triamcinolone acetonide (IVTA) between vitrectomised and non-vitrectomised eyes in patients with diabetes diabetic macular oedema (DME).Retrospective comparative study.Medical records of 157 (157 eyes) type 2 who received IVTA for DME were reviewed, best-corrected visual acuity, IOP optical central retinal thickness (CRT) compared preoperatively, at 1, 4, 12 24 weeks groups.IOP significantly increased 1 (p<0.0001), 4 8...