A5051758061- NF-κB Signaling Pathways
- Cancer-related gene regulation
- TGF-β signaling in diseases
- interferon and immune responses
- Cell death mechanisms and regulation
- Melanoma and MAPK Pathways
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Protein Kinase Regulation and GTPase Signaling
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- FOXO transcription factor regulation
- RNA regulation and disease
- Kruppel-like factors research
- Retinoids in leukemia and cellular processes
- Bone Metabolism and Diseases
- Renal and related cancers
- Phosphorus and nutrient management
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- Lipid metabolism and biosynthesis
- Protease and Inhibitor Mechanisms
- Connective Tissue Growth Factor Research
- Soft tissue tumors and treatment
Boditech Med (South Korea)
2021-2023
Seoul National University
2017-2022
Advanced Institute of Convergence Technology
2017-2021
CHA University
2013-2016
Gachon University
2010
University of Ulsan
2003-2005
Abstract Although tetraarsenic hexoxide is known to exert an anti-tumor effect by inducing apoptosis in various cancer cells, its on other forms of regulated cell death remains unclear. Here, we show that induces the pyroptotic through activation mitochondrial reactive oxygen species (ROS)-mediated caspase-3/gasdermin E (GSDME) pathway, thereby suppressing tumor growth and metastasis triple-negative breast (TNBC) cells. Interestingly, hexoxide-treated TNBC cells exhibited specific...
Abstract Mesenchymal stromal cells (MSCs) differentiation into different lineages is precisely controlled by signaling pathways. Given that protein kinases play a crucial role in signal transduction, here we show Microtubule Associated Serine/Threonine Kinase Family Member 4 (Mast4) serves as an important mediator of TGF-β and Wnt transduction regulating chondro-osteogenic MSCs. Suppression Mast4 TGF-β1 led to increased Sox9 stability blocking Mast4-induced serine 494 phosphorylation...
Triple-negative breast cancer (TNBC) is considered incurable with currently available treatments, highlighting the need for therapeutic targets and predictive biomarkers. Here, we report a unique role Bcl-2-associated athanogene 2 (BAG2), which significantly overexpressed in TNBC, regulating dual functions of cathepsin B as either pro- or anti-oncogenic enzyme. Silencing BAG2 suppresses tumorigenesis lung metastasis induces apoptosis by increasing intracellular mature form B, whereas...
Abstract Although accumulating evidence indicates that alternative splicing is aberrantly altered in many cancers, the functional mechanism remains to be elucidated. Here, we show epithelial and mesenchymal isoform switches of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) regulated by regulatory 1 (ESRP1) correlate with metastatic potential gastric cancer cells. We found expression variants LRRFIP2 was closely correlated ESRP1 . Surprisingly, ectopic (variant 3) dramatically...
Despite favorable responses to initial chemotherapy, drug resistance is a major cause limiting chemotherapeutic efficacy in many advanced cancers. However, mechanisms that drive drug-specific chemotherapy for patients with cancers are still unclear. Here, we report unique role of death-associated protein kinase-related apoptosis-inducing kinase 1 (DRAK1) associated paclitaxel cervical cancer cells. Interestingly, DRAK1 level was markedly decreased paclitaxel-resistant cells without affecting...
Renal fibrosis is a common consequence of unilateral ureteral obstruction, which provides useful model to investigate the pathogenesis obstructive nephropathy and progressive renal fibrosis. Transforming growth factor (TGF-β1) has been recognized as key mediator in by stimulating matrix-producing fibrogenic cells promoting extracellular matrix deposition. Therefore, considerable efforts have made regulate TGF-β signaling for antifibrotic therapy. Here, we investigated mode action glucosamine...
Abstract Although advanced lipidomics technology facilitates quantitation of intracellular lipid components, little is known about the regulation metabolism in cancer cells. Here, we show that disruption Gdpd3 gene encoding a lysophospholipase D enzyme significantly decreased self-renewal capacity murine chronic myelogenous leukaemia (CML) stem cells vivo. Sophisticated analyses revealed deficiency reduced levels certain lysophosphatidic acids (LPAs) and mediators CML Loss also activated...
Multinucleation is a hallmark of osteoclast formation and has unique ability to resorb bone matrix. During differentiation, the cytoskeleton reorganization results in generation actin belts eventual resorption. Tetraspanins are involved adhesion, migration fusion various cells. However, its function still unclear. In this study, we identified Tm4sf19, member tetraspanin family, as regulator function.
ELK3 is a member of the Ets family transcription factors. Its expression associated with angiogenesis, vasculogenesis, and chondrogenesis. inhibits endothelial migration tube formation through regulation MT1-MMP transcription. This study assessed function in breast cancer (BC) cells by comparing its between basal luminal silico vitro. In analysis showed that was higher more aggressive BC than cells. Similarly, vitro mRNA protein normal To investigate whether regulates cell or invasion,...
The adaptor protein TNF receptor-associated factor 6 (TRAF6) is a key mediator in inflammation. However, the molecular mechanisms controlling its activity and stability cancer progression remain unclear. Here we show that death-associated kinase-related apoptosis-inducing kinase 1 (DRAK1) inhibits proinflammatory signaling pathway by targeting TRAF6 for degradation, thereby suppressing inflammatory signaling-mediated tumor growth metastasis advanced cervical cells. DRAK1 bound directly to...
Abstract The signaling pathways governing acetaminophen (APAP)-induced liver injury have been extensively studied. However, little is known about the ubiquitin-modifying enzymes needed for regulation of APAP-induced injury. Here, we examined whether Pellino3 protein, which has E3 ligase activity, and subsequently explored its molecular mechanism. Whole-body Peli3 −/− knockout (KO) adenovirus-mediated knockdown (KD) mice showed reduced levels centrilobular cell death, infiltration immune...
Abstract Background This study aimed to investigate how aging alters the homeostasis of colonic intestinal epithelium and regeneration after tissue injury using organoid models identify its underlying molecular mechanism. Methods To aging-related changes in epithelium, we conducted cultures from old (older than 80 weeks) young (6–10 mice compared number size organoids at day 5 passage 0 growth rate between two groups. Results The was significantly lower that ( p < 0.0001) 0. old-mouse 4...
Proposed binding mode of TRD-35 (thick cyan sticks) in the DRAK2. Appendix S1. Experimental procedure and analytical data for selected intermediates inhibitors. Please note: The publisher is not responsible content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.
// Hee-Jin Ahn 1 , Kwang-Soo Kim Kyung-Won Shin 2 Kee-Hwan Lim Jin-Ock Je-Yong Lee Jiewan Ji-Hoon Park Kyung-Min Yang 3 Kwang-Hyun Baek Jeong-Jae Ko Kyung-Soon Department of Biomedical Science, College Life Science and CHA Stem Cell Institute, University, Seoul, Korea Graduate School Cancer Correspondence to: Park, e-mail: kspark@cha.ac.kr Keywords: Ell3, p53, cis-diamminedichloroplatinum(II) (CDDP), NAD(P)H quinone oxidoreductase (NQO1), interleukin-20 (IL20) Received: April 27, 2015...
Transition metal dichalcogenides (TMDs) have been considered as promising candidates for transparent and flexible optoelectronic devices owing to their large exciton binding energy strong light-matter interaction. However, monolayer (1L) TMDs exhibited different intensities spectra of photoluminescence (PL), the characteristics electronic also differed in each study. This has explained terms various defects TMDs, such vacancies grain boundaries, surroundings, dielectric screening charged...
Sujin Park, Kyung-Min Yang, Yuna Eunji Hong, Chang Pyo Jinah Kyoungwha Pang, Jihee Lee, Bora Siyoung Haein An, Mi-Kyung Kwak, Junil Kim, Jin Muk Kang, Pyunggang Yang Xiao, Guangjun Nie, Akira Ooshima, and Seong-Jin Kim. Journal of Cancer Prevention 2018;23:1-9. https://doi.org/10.15430/JCP.2018.23.1.1
(1) Background: Desmoid tumors have a relatively high local failure rate after primary treatment using surgery and/or radiotherapy. Moreover, desmoid recur at the site for many patients. An effective therapeutic strategy tumor is needed to maintain quality of life and prolong survival. (2) Method: First all, we collected tissues investigated status protein expression beta-catenin alpha-SMA through immunohistochemistry. Then, performed targeted sequencing whole RNA sequencing. To compare data...
Abstract Death‐associated protein kinase‐related apoptosis‐inducing kinase 2 (DRAK2) has become a promising target for drug development. In search of novel and selective DRAK2 inhibitor motif, in vitro screen assay was established performed using in‐house chemical libraries. After through hit triage procedure, N ‐(3,5‐dichlorophenyl)‐5‐fluoro‐ 4 ‐methylpyrimidine‐2,4‐diamine ( 1 ) selected as initial with structural novelty drug‐likeness. During validation, structure–activity relationship...
Few studies have examined the role of BAG2 in malignancies. We investigated prognostic value BAG2-expression cancer-associated fibroblasts (CAFs) and tumor cells predicting metastasis-free survival patients with breast cancer. Tissue-microarray was constructed using human cancer tissues obtained by surgical resection between 1992 2015. expression evaluated immunohistochemistry CAFs or cells. cytoplasm classified as positive negative, low high, respectively. BAG2-CAF 310 67 (21.6%) patients....
Abstract Modified arsenic derivative compounds such as trioxide (As2O3), trisulfide (As2S3), and tetraarsenic hexoxide (As4O6) have been known to be one of the potent anti-cytotoxic effects in various cancer cells, including leukemia, glioma, colon, breast, cervix cells. Particularly, was developed a chemotherapeutic agent for patients with advanced cancers. Although anti-cancer effect has extensively studied molecular basis its tumor inhibitory activity remains poorly understood. In this...
Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide a highly malignant associated with poor prognosis low overall survival. Here, we describe role of DRAK1 (DAP kinase-related apoptosis-inducing kinase 1) in head cells. significantly overexpressed primary tumors lines. Overexpression decreased TGF-β1-induced transcriptional activity expression tumor suppressor target genes, including p15, p21, whereas silencing enhanced. Furthermore, endogenous...
<div>Abstract<p>The adaptor protein TNF receptor-associated factor 6 (TRAF6) is a key mediator in inflammation. However, the molecular mechanisms controlling its activity and stability cancer progression remain unclear. Here we show that death-associated kinase-related apoptosis-inducing kinase 1 (DRAK1) inhibits proinflammatory signaling pathway by targeting TRAF6 for degradation, thereby suppressing inflammatory signaling-mediated tumor growth metastasis advanced cervical...