A5087917122- Immune Cell Function and Interaction
- Immune cells in cancer
- Food Quality and Safety Studies
- Immunotherapy and Immune Responses
- Education and Learning Interventions
- Hematopoietic Stem Cell Transplantation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Biosensing Techniques and Applications
- Diverse Approaches in Healthcare and Education Studies
- Biosensors and Analytical Detection
- Immune Response and Inflammation
- Effects and risks of endocrine disrupting chemicals
- Advanced biosensing and bioanalysis techniques
- Probiotics and Fermented Foods
- Diverse Topics in Contemporary Research
- CAR-T cell therapy research
- Inflammation biomarkers and pathways
- dental development and anomalies
- Virus-based gene therapy research
- Erythrocyte Function and Pathophysiology
- FOXO transcription factor regulation
- Psychosocial Factors Impacting Youth
- Structural Load-Bearing Analysis
- Educational Systems and Policies
- Protist diversity and phylogeny
University at Buffalo, State University of New York
2021-2025
Kookmin University
2022
Cincinnati Children's Hospital Medical Center
2015-2020
Seoul National University
2008-2019
National Institute of Food and Drug Safety Evaluation
2016
Ministry of Food and Drug Safety
2016
International Vaccine Institute
2013
Inje University
2013
Korea Research Institute of Standards and Science
2005
Chungnam National University
2005
Abstract Invariant NKT (iNKT) cells are a distinct subset of T lymphocytes that recognize glycolipid Ags. Upon TCR stimulation, iNKT promptly secrete wide range cytokines and therefore have been investigated as target for immunotherapy. However, after primary activation, become hyporesponsive toward their ligand (anergy). The further mechanism behind cell anergy is poorly understood. We found low level programmed death-1 (PD-1) was constitutively expressed on PD-1 expression increased...
Abstract Myeloid-derived suppressor cells (MDSCs), which are known to be accumulated in the blood, spleen, and bone marrow of tumor-bearing mice cancer patients, were tested as APCs for a cellular vaccine because they have phenotypical similarity with inflammatory monocytes may differentiated from same precursors monocytes. Although MDSCs immunosuppressive properties, vivo transferred MDSCs, present tumor Ag NKT cell ligand (α-galactosylceramide), significantly prolonged survival time...
Obesity is a chronic organismal stress that disrupts multiple systemic and tissue-specific functions. In this study, we describe the impact of obesity on activity hematopoietic stem cell (HSC) compartment. We show alters composition HSC compartment its in response to stress. The function progressively acquired but persists after weight loss or transplantation into normal environment. Mechanistically, establish oxidative induced by dysregulates expression transcription factor Gfi1 increased...
Due to the acceleration of information and communication technology in Fourth Industrial Revolution, artificial intelligence has had a large impact on politics, economy, culture, art industries. During COVID-19 pandemic, as face-to-face activities declined video conferencing expanded, new platform, called metaverse, appeared. The metaverse is digital technology, that become known public through games entertainment, it gradually expanding. also provides education methods. For high value-added...
MLL4, also known as KMT2D, is a histone methyltransferase that acts an important epigenetic regulator in various organogenesis programs. Mutations the MLL4 gene are major cause of Kabuki syndrome, human developmental disorder involves craniofacial birth defects, including anomalies palate. This study aimed to investigate role and underlying mechanisms development growth We generated novel conditional knockout (cKO) mouse model with tissue-specific deletion Mll4 palatal mesenchyme. Using...
Tooth enamel, the hardest tissue in vertebrates, is crucial for mastication and dental protection. Its formation depends on enamel organ (EO), a specialized epithelial structure derived from oral epithelium. A fundamental question persists: how does uniform epithelium differentiate into diverse EO cell types? While p63, master regulator of ectodermal development, coordinates multiple signaling pathways essential placode formation, its specific roles development remain unclear due to early...
Abstract How myeloid-derived suppressor cells (MDSC) emerge in the tumor environment remains unclear. Here, we report that GM-CSF can convert natural killer (NK) into MDSCs. When transferred tumor-bearing mice, adoptively NK lost their phenotype and were converted Ly6ChighLy6Ghigh MDSC. This conversion was abolished by exposure to IL-2 either vitro or vivo. Notably, found of 4 maturation stages based on CD11b/CD27 expression levels, only CD11bhighCD27high could be CD11b+Gr1+ MDSC ex Transfer...
Abstract Myeloid-derived suppressor cells (MDSCs) are increased by tumor-derived factors and suppress anti-tumor immunity. MDSCs obtained at a late time point after tumor injection had stronger suppressive activity than an early point, as measured T cell proliferation assays. To find in that change during growth, we analyzed gene expression profiles from different points injection. We found immune response-related genes were downregulated but protumor function-related upregulated both...
Clonixic acid is currently marketed as a salt form because of its poor water-solubility. However, the commercial dosage causes severe pain after intramuscular or intravenous injection. To improve solubility clonixic and to reduce on injection, was incorporated into oil-in-water microemulsions prepared from pre-microemulsion concentrate composed varying ratios oil surfactant mixture. As an phase for drug incorporation, up 14% castor could be included in without significant increase droplet...
Despite the advantages of using adenoviral vectors for specific antigenic gene delivery in development antigen-presenting cell (APC)-based vaccines, lack coxsackievirus–adenovirus receptor (CAR) on APCs limits use vitro delivery. In this study, we used a recombinant adapter protein, CFm40L, which consists ectodomain CAR genetically fused to CD40 ligand (CD40L) via trimerization motif, target Her-2/neu- or human papillomavirus 16 (HPV16) E6/E7-encoding adenoviruses dendritic cells (DCs) and B...
Cadmium, a heavy metal pollutant, causes cancer. The existence of cancer stem cells (CSCs) in tumors is widely considered to be the reason for recurrence and treatment failure Increasing evidence has confirmed that under certain conditions non-CSCs could converted into CSCs. impact cadmium on development CSC lineage bulk tumor cell population not yet studied. aim this study was evaluate effect conversion CSCs identification based concurrent monitoring multiple markers. High-content molecular...
An accurate, rapid, and cost-effective methodology for enzyme inhibitor assays is highly needed large-scale screening to evaluate the efficacy of drugs at molecular level. For first time, we have developed an inkjet printing-based inhibition assay assessment drug activity using a conventional printer composed four cartridges. The based on determination number moles printed surface. was quantified through volume substance ejected onto reaction spot determined from density reagent ink solution...
MLL4, also known as KMT2D, is a histone methyltransferase that acts an important epigenetic regulator in various organogenesis programs. Mutations the MLL4 gene are major cause of Kabuki syndrome, human developmental disorder involves craniofacial birth defects, including anomalies palate. This study aimed to investigate role and underlying mechanisms development growth We generated novel conditional knockout (cKO) mouse model with tissue-specific deletion Mll4 palatal mesenchyme. Using...
Salt is one of the most important factors for fermented foods, but effect salt treatment time on quality foods has rarely been studied. In this study, different times (0, 48, and 96 h) after start fermentation soy sauce moromi extract (SSME) was investigated. As delayed, population Aspergillus oryzae, Lactobacillaceae, Enterococcaecea in SSME increased, whereas Staphylococcaceae Bacillaceae decreased, leading to changes enzymatic activity metabolite profiles. particular, contents amino...
Abstract For the first time, a paper-based fluorescence resonance energy transfer (FRET) determination with cyclic AMP (cAMP)-specific phosphodiesterase 4B (PDE4B) inhibitory assay using an inkjet-printing technique is proposed. Non-fabricated parchment paper found to constitute unique substrate measure fluorescent transfer, due its insignificant self-absorption, and enables efficient sample interaction. Here, we report responsive FRET signals generated on paper, upon sequentially printing...
In silico analysis of genome the cyanobacterium Synechocystis sp. PCC 6803 identified two genes, slr0329 and sll0593, that might participate in glucose (Glc) phosphorylation (www.kazusa.or.jp/cyano). order to determine functions these we generated deletion mutants, analyzed their phenotypes enzymatic activities. presence 10 mM Glc, wild-type (WT) defective strain (M1) grew fast with increased respiratory activity NADPH production, whereas sll0593 mutant (M2) failed show any Glc responses. WT...