A5065828962- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- CRISPR and Genetic Engineering
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- Retinal Development and Disorders
- Advanced Photocatalysis Techniques
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
Seoul National University
2015-2022
Government of the Republic of Korea
2020
Seoul Institute
2020
Institute for Basic Science
2015-2018
Abstract Recently, there have been significant advances in the field of RNA‐based therapeutics harnessing exogenous RNAs including small interfering RNA (siRNA), microRNA (miRNA) mimics, and vitro transcribed (IVT) mRNAs. are one most attractive classes drugs for treating a variety diseases. In principle, offer numerous advantages compared to conventional small‐molecule‐based therapies. However, several drawbacks overcome application therapeutics, instability presence various biological...
Abstract MicroRNAs (miRNAs) are important regulatory RNAs that control gene expression in various biological processes. Therefore, over the disease-related miRNA is both for basic research and a new class of therapeutic modality to treat serious diseases such as cancer. Here, we present high-throughput screening strategy identify small molecules modulate living cells. The screen enables simultaneous monitoring phenotypic cellular changes associated with by measuring quantitative fluorescent...
Herein, hybrid nanocomposite of praseodymium doped TiO 2 nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As‐synthesized Pr‐TiO /NGO exhibits enhanced photocatalytic activity under visible light irradiation the intact lanthanide mediated band gap narrowing compared to . Moreover, high payload controlled release doxorubicin charge reversal at endosomal pH near‐infrared efficient photothermal conversion provide highly favorable features in therapeutic...
Abstract Artificial, synthetic chaperones have attracted much attention in biomedical research due to their ability control the folding of proteins and peptides. Here, we report bio-inspired multifunctional porous nanoparticles modulate proper intracellular delivery therapeutic α-helical peptide. The S ynthetic N ano- C haperone for P eptide (SNCP) based on provides an internal hydrophobic environment which contributes stabilizing secondary structure encapsulated peptides environments. In...
A fluorescent nanobiosensor for efficient quantitative analysis of the cancer-associated, m<sup>6</sup>A RNA demethylase ALKBH5 activity is developed, which shows high potential robust anticancer drug screening against demethylase.
A grand slam in cancer therapy: On page 1833 Dal-Hee Min and co-workers describe how they designed a hybrid nanomaterial with triple action modes: chemo, photothermal photodynamic. This powerful therapeutic, that showed good results human cells, is based on graphene oxide, the surface of which covered praseodymium doped titanium dioxide.
Although genome editing technologies based on the CRISPR/Cas9 system have rapidly advanced, methods of isolating positive clones still include either risk distortion in protein structure/function or unsuitability to efficient screening. For enrichment CRISPR/Cas9-mediated knockin cells, we developed a graphene oxide-based fluorescent nanobiosensor, GO-GEMS ( G raphene O xide-based ene E xpression M onitoring S ensor), detect mRNA expression living cells. that consist dextran-coated reduced...