A5108060220- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Acute Myocardial Infarction Research
- Aortic Disease and Treatment Approaches
- MicroRNA in disease regulation
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Air Quality and Health Impacts
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Air Quality Monitoring and Forecasting
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and Vascular Pathologies
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Disease Prevention
- Infective Endocarditis Diagnosis and Management
- Advanced Machining and Optimization Techniques
- COVID-19 impact on air quality
- Genetic Associations and Epidemiology
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Gout, Hyperuricemia, Uric Acid
Guangdong Academy of Medical Sciences
2013-2024
Southern Medical University
2021-2024
Guangdong Provincial People's Hospital
2020-2024
South China University of Technology
2016-2021
Guangdong General Hospital
2011-2017
Guangzhou First People's Hospital
2013
Guangzhou Medical University
2013
Sun Yat-sen Memorial Hospital
2013
Sun Yat-sen University
2013
Abstract Background Cardiovascular disease (CVD) caused by air pollution poses a considerable burden on public health. We aim to examine whether lifestyle factors mediate the associations of pollutant exposure with risk CVD and extent interaction between lifestyles regarding outcomes. Methods included 7000 participants in 2011–2012 followed up until 2018. The evaluation consists six as proxies, including blood pressure, glucose, lipids, body mass index, tobacco exposure, physical activity,...
Backgrounds: Emerging evidence suggests that stress hyperglycemia ratio (SHR), an index of relative hyperglycemia, is great prognostic value in acute myocardial infarction (AMI), but current limited elderly patients. In this study, we aimed to assess whether SHR associated with in-hospital outcomes patients AMI. Methods: retrospective who were aged over 75 years and diagnosed AMI consecutively enrolled from 2015, January 1st 2019, December 31th. Admission blood glucose glycosylated...
Tachycardia-induced atrial fibrosis is a hallmark of the structural remodeling fibrillation (AF). The mechanisms underlying tachycardia-induced remain unclear. In our previous study, we found that Smad7-downregulation promoted development in AF. Fibroblasts are enriched microRNA-21 (miR-21), which contributes to and heart failure cardiovascular system. Our study was designed test hypothesis miR-21 reinforces TGF-β1/Smad signaling pathway AF-induced by down-regulating Smad7. Rapid pacing...
Introduction: Primary or emergent percutaneous coronary intervention (PCI) with stenting is the standard treatment for patients ST-segment elevation myocardial infarction (STEMI) non-STEMI acute syndromes (ACS) at high risk. The value of delayed following balloon-facilitated reperfusion in these largely unknown. Methods and analysis: This systematic review aims to assess whether (vs immediate stenting) improves angiographic cardiovascular clinical outcomes STEMI ACS undergoing primary PCI....
Abstract Background Elevated lipoprotein(a) [Lp(a)] levels predict cardiovascular events incidence in patients with coronary artery disease (CAD). Genetic variants the rs3798220, rs10455872 and rs6415084 single-nucleotide polymorphisms (SNPs) Lp(a) gene ( LPA ) correlate elevated levels, but whether these SNPs have prognostic value for CAD is unknown. The present study evaluated association of subsequent after percutaneous intervention (PCI). Methods TaqMan SNP genotyping assays were...
Background Adipose-derived mesenchymal stem cells (ASCs) transplantation is a promising approach for myocardium repair. Promotion of ASCs migration and survival the key improving efficiency. SDF-1α critical factor responsible survival. Atorvastatin (Ator) capable up-regulating SDF-1α. Therefore, we're going to investigate whether could be improved with atorvastatin. Methods In vitro study, cardiomyocytes were subjected anoxia-reoxygenation injury subsequently divided into different groups:...
To investigate relationship between glycated hemoglobin (HbA1c) level and coronary artery disease (CAD) severity. Observational study was conducted 573 participants were enrolled baseline characteristics collected. Clinical presentations in terms of stable angina, unstable angina or acute myocardial infarction diagnosed. All performed angiography to figure out the numbers stenosis none-stenosis (< 50% stenosis), single multiple vessels stenoses (≥ stenosis). divided into subgroups according...
Infective endocarditis (IE) is associated with increased neutrophil and reduced platelet counts. We assessed the relationship between neutrophil-to-platelet ratio (NPR) on admission adverse outcomes in patients IE.Patients diagnosed IE January 2009 July 2015 (n=1293) were enrolled, 1046 finally entered into study. Study subjects categorized four groups according to NPR quartiles: Q1<18.9 (n=260); Q2: 18.9-27.7 (n=258); Q3: 27.7-43.3 (n=266); Q4>43.3 (n=262). Cox proportional hazards...
Background and Aim . Incidence of coronary restenosis after stent placement is high. Our study was going to investigate whether Lp(a) elevation potential for predicting the effects on were dependent LDL-C level. Methods Results Totally 832 participants eligible enrolled followed up monitoring clinical end points. Baseline characteristics collected. According cut point Lp(a), divided into low group (Lp(a) < 30 mg/dL) high ≥ mg/dL). Furthermore, based baseline level, 1.8 mmol/L ≥1.8...
Background There is no consistent evidence to suggest the association of plasma lipoprotein(a) (Lp[a]) with long‐term mortality in patients undergoing coronary angiography ( CAG ) or percutaneous intervention PCI ). Hypothesis Level Lp(a) associated following . Methods We enrolled 1684 data between April 2009 and December 2013. The were divided into 2 groups: a low‐Lp(a) group (Lp[a] <16.0 mg/ dL ; n = 842) high‐Lp(a) ≥16.0 842). Results In‐hospital was not significantly different high...
Objectives: The aim of this study is to evaluate the relationship miR-30 with office and ambulatory blood pressure parameters carotid intima-media thickness (CIMT) in patients hypertension healthy controls. Methods: We assessed expression level 40 essential individuals. All underwent artery ultrasonography, monitoring. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was used selected miR-30. correlation between CIMT using Spearman coefficient. Multiple logistic...
Aims . To investigate the impact of chronic total occlusion (CTO) in non-infarct-related artery (IRA) on long-term prognosis and evaluate clinical significance staged revascularization patients with ST-segment elevation myocardial infarction (STEMI). Methods 1266 STEMI primary percutaneous coronary intervention (PCI) were categorized as single-vessel disease (SVD), multivessel (MVD) without CTO. We study outcomes after PCI following 3 years. Additionally, CTO received revascularization,...
Introduction:The effects of statins on lipoprotein-associated phospholipase A2 (Lp-PLA2) are controversial, and the present study aimed to investigate whether atorvastatin could reduce Lp-PLA2 in rats with dyslipidemia.Material methods: A high-fat high-cholesterol diet was prescribed produce a dyslipidemia model.Thereafter, low-dose (5 mg/ kg/day), high-dose (20 mg/kg/day) or saline (without-treatment group) for 14 days.At 6 weeks after model establishment days treatment, fasting venous...
Background Sequence variants in the β-adrenergic receptor ( ADRB ) genes have a close relationship with development of coronary artery disease (CAD) and patient's prognosis. However, there is lack data on role ADRBs Han Chinese patients CAD. We aimed to investigate association genetic ADRB1 ADRB2 incidence major adverse cardiac event (MACE) Methods A total 545 CAD undergoing percutaneous intervention (PCI) were recruited study followed for one year. Three variant sites (rs1801253) (rs1042713...
Background: Among the population without cardiovascular diseases (CVD), it is unclear whether pre-diabetes and/or prehypertension elevated risk of all-cause and mortality. Methods: All participants CVD at baseline were recruited from 1999– 2014 National Health Nutrition Examination Survey (NHANES), with survival status being updated until 31 December 2015. Cox proportional hazards models subgroup analyses performed to estimate hazard ratios (HRs) 95% confidence interval (CI). Results: There...
Lipoprotein(a) (Lp[a]) is well-known as a residual risk factor for coronary artery disease (CAD). However, the different adverse effects of Lp(a) about CAD in patients with or without type 2 diabetes mellitus (T2DM) are unclear. This study aimed to investigate thresholds diagnosis T2DM and non-T2DM patients, further compare alarm values along optimal low-density lipoprotein cholesterol (LDL-C) level.This retrospective consecutively enrolled suspected who underwent angiography Guangdong...
Cardiogenic shock (CS) is the leading cause of death in patients with acute myocardial infarction (AMI) despite advances care. This study aims to derive and validate a risk score for in-hospital development CS AMI.In this study, we used Improving Care Cardiovascular Disease China-Acute Coronary Syndrome (CCC-ACS) registry 76,807 model internal validation. These came from 158 tertiary hospitals 82 secondary between 2014 2019, presenting AMI without upon admission. The eligible were randomly...
Abstract Background Low-density lipoprotein cholesterol (LDL-c) has been proven to be a risk factor for atherosclerotic cardiovascular disease (CVD), while (a) (Lp(a)) is residual CVD, even though LDL-c well controlled by statin use. Importantly, the role of Lp(a) in renal artery stenosis (ARAS) still unknown. Methods For this hospital-based cross-sectional study, patients who simultaneously underwent coronary and angiography were examined. ARAS was defined as 50% reduction (two-dimensional...
Abstract Background Remnant cholesterol (RC) is recognized as a risk factor for diabetes mellitus (DM). Although iron status has been shown to be associated with metabolism and DM, the association between RC, status, DM remains unclear. We examined relationship RC investigated role of in DM. Methods A total 7308 patients were enrolled from China Health Nutrition Survey. was calculated minus low-density lipoprotein high-density cholesterol. Iron assessed serum ferritin (SF) body (TBI)....