A5101850606- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Systemic Sclerosis and Related Diseases
- Cancer Cells and Metastasis
- Adipose Tissue and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Protein Tyrosine Phosphatases
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Protein Hydrolysis and Bioactive Peptides
- Biomarkers in Disease Mechanisms
- interferon and immune responses
- Heat shock proteins research
- RNA Interference and Gene Delivery
- Lymphatic System and Diseases
- Galectins and Cancer Biology
- Metabolomics and Mass Spectrometry Studies
- NF-κB Signaling Pathways
- 14-3-3 protein interactions
Southwest Medical University
2017-2025
Sun Yat-sen University
2008-2025
Sichuan University
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Sun Yat-sen Memorial Hospital
2021-2024
Tongde Hospital of Zhejiang Province
2024
Shantou University
2024
State Key Laboratory of Oncology in South China
2021-2024
Science and Technology Department of Sichuan Province
2024
Circular RNAs (circRNA) containing retained introns are normally sequestered in the nucleus. Dysregulation of cellular homeostasis can drive their nuclear export, which may be involved cancer metastasis. However, mechanism underlying circRNA export and its role lymph node (LN) metastasis bladder remain unclear. Here, we identify an intron-retained circRNA, circNCOR1, that is significantly downregulated LN metastatic negatively associated with poor prognosis patients. Overexpression circNCOR1...
Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma (PDAC) and predicts poor prognosis for patients. The KRASG12D mutation confers an aggressive PDAC phenotype that is susceptible to lymphatic dissemination. However, the regulatory mechanism underlying mutation-driven LN remains unclear. Herein, we found with (KRASG12D PDAC) sustained extracellular vesicle-mediated (EV-mediated) transmission of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) a...
NOTCH1 is a poor prognostic factor for breast cancer and associated with stem cells Ying Zhong,1 Songjie Shen,1 Yidong Zhou,1 Feng Mao,1 Yan Lin,1 Jinghong Guan,1 Yali Xu,1 Shu Zhang,2 Xu Liu,3 Qiang Sun1 1Department of Breast Disease, 2Department Dermatology, Peking Union Medical College Hospital, 3Centralab Institute Basic Sciences, Chinese Academy Beijing, People’s Republic China Abstract: Recently, the human gene has been found to be implicated in cell metastasis maintenance cells....
Glucocorticoids (GCs) overuse is associated with decreased bone mass and osseous vasculature destruction, leading to severe osteoporosis. Platelet lysates (PL) as a pool of growth factors (GFs) were widely used in local repair by its potent pro-regeneration pro-angiogenesis. However, it still seldom applied for treating systemic osteopathia due the lack suitable delivery strategy. The non-targeted distribution GFs might cause tumorigenesis other organs. In this study, PL-derived exosomes...
Abstract Background Overlapping cases of systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are rare have not yet been fully proven to be accidental or a common genetic basis. Methods Two-sample bidirectional Mendelian randomization (MR) analysis was applied explore the potential causal relationship between SLE PBC. The heterogeneity reliability MR were evaluated through Cochran’s Q -test sensitivity test, respectively. Next, transcriptome overlap PBC performed using Gene...
Previously, we have shown that ASK1-interacting protein 1 (AIP1, also known as DAB2IP), a novel member of the Ras-GAP (Ras-GTPase-activating protein) family, opens its conformation in response to tumor necrosis factor (TNF), allowing it form complex with TRAF2-ASK1 leads activation ASK1-JNK/p38 signaling endothelial cells (EC). In present study, show TNF-inducible 14-3-3-binding site on AIP1 is critical for opening and AIP1-mediated TNF signaling. Ser-604, located C-terminal domain AIP1, was...
Previously we have shown that AIP1 (apoptosis signal-regulating kinase [ASK]1-interacting protein 1), a novel member of the Ras-GAP family, facilitates dephosphorylation ASK1 at pSer967 and subsequently 14-3-3 release from ASK1, leading to enhanced ASK1-JNK signaling. However, phosphatase(s) responsible for has not been identified. In present study, identified phosphatase (PP)2A as potential in vascular endothelial cells (ECs). Tumor necrosis factor (TNF)-induced ECs was blocked by PP2A...
Abstract Background Cancer‐associated fibroblasts (CAFs) play a vital role in facilitating tumor progression through extensive reciprocal interplay with cancer cells. Tumor‐derived extracellular vesicles (EVs) are the critical mediators involved crosstalk between cells and stromal cells, contributing to metastasis of cancers. Yet, biological mechanisms tumor‐derived EVs triggering CAFs phenotype stimulate lymph node (LN) bladder (BCa) largely unknown. Here, we aimed explore effects molecular...
Individuals affected with glaucoma and cataracts are more likely to experience depressive symptoms, which can affect their overall quality of life (QOL) functioning. Therefore, this retrospective cohort study aimed evaluate the impact cognitive behavioral therapy (CBT) on or patients mild moderate depression. This included depression resulting from in our hospital January 2023 December 2023. The participants were divided into an untreated group a based different intervention methods. We...
This study explored the relationship between illness cognitions (helplessness, acceptance, and perceived benefits) psychological distress in colorectal cancer couples. A cross-sectional involving 403 patients aged 26–59, diagnosed within 5 years, their spouses China was conducted from May to September 2023. Self-report questionnaires assessed cognitions, dyadic coping, distress. The results revealed that positive (acceptance helplessness of both had direct indirect effects on own through...
Ursolic acid (UA) is widely found in many dietary plants, which has been proved to be effective cancer therapy. But unfortunately its hydrophobic property limits clinical application. Polymer micelles (PMs) are constructed from amphiphilic block copolymers that tend self-assemble and form the unique core-shell structure consisting of a hydrophilic corona outside inner core. PMs could entrap substance into core for solubilizing these poorly water-soluble drugs it applied as novel nano-sized...
The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion butyric (BA) fermented by rat fecal microbiota construct an acetyl CoA pathway. According growth curves, compositions at 10 and 36 h were further analyzed. in LRS group had higher richness diversity compared glucose (GLU) high amylose maize (HAMS). Moreover, isotope LA promoted Lactobacillus Bifidobacterium, BA production, inhibited Escherichia-Shigella. BUT pathway played a dominant...
Local recurrence is a therapeutic challenge for radiofrequency ablation (RFA) in treatment of small solid focal malignancies. Here we show that RFA induced heat shock proteins (HSPs) expression and high mobility group box-1 (HMGB1) translocation xenografted melanoma, which might create proinflammatory microenvironment favors tumor antigen presentation activation the effector T cells. On this basis, investigate whether prime-boost strategy combining prime with heat-shocked cell lysate-pulsed...
FGFR1 is a receptor tyrosine kinase deregulated in certain breast cancers (BCs) with poor prognosis.Although FGFR1-activated phosphorylation cascades have been mapped, the key genes regulated by BC are largely unclear.FOXQ1 an oncogenic transcription factor.Although we found that activation of robustly upregulated FOXQ1 mRNA, how regulates gene expression and whether essential for FGFR1-stimulated cell proliferation unknown.Herein, confirmed mRNA protein cells.Knockdown blocked...
Abnormal expression of O-Linked β-N-acetylglucosamine (O-GlcNAc) and β-catenin is a general feature cancer contributes to transformed phenotypes. In this study, we identified the interaction between O-GlcNAc β-catenin, explored their effects on progression liver cancer. Our results demonstrated that upregulation was induced by high glucose, whereas application PuGNAc GlcNAc increased protein levels, as well protein's stability nuclear accumulation in cell lines HEP-G2 HuH-7. addition,...
Although ductal carcinoma in situ (DCIS) is a non-invasive breast cancer, many DCIS lesions may progress to invasive cancer and the genes pathways responsible for its progression are largely unknown. FGFR1 plays an important role cell proliferation, differentiation carcinogenesis. The purpose of this study examine roles signaling gene expression, tumor growth model.DCIS.COM cells were transfected with empty vector generate DCIS-Ctrl cells. DCIS-iFGFR1 AP20187-inducible iFGFR1 consists v-Src...
In this study, antioxidant peptides were prepared from hairtail surimi by hydrolysis. Response surface methodology coupled with a Box-Behnken design was applied to optimize hydrolysis conditions. The optimum conditions determined as: 12.1 h incubation time, 44.74 °C temperature and enzyme concentration 1858.85 U/g. amino acid compositions analysis showed most abundant in (HAP) Glutamic followed Aspartic Lysine. addition, the fraction of HAP molecular weight less than 3 kDa strongest activity...