A5075990807- RNA modifications and cancer
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Mechanisms of cancer metastasis
- Crystallization and Solubility Studies
- Lymphatic System and Diseases
- X-ray Diffraction in Crystallography
- Supercapacitor Materials and Fabrication
- Ubiquitin and proteasome pathways
- Quality and Safety in Healthcare
- Extracellular vesicles in disease
- PI3K/AKT/mTOR signaling in cancer
- Vascular Malformations and Hemangiomas
- Systemic Sclerosis and Related Diseases
- Electrical Fault Detection and Protection
- Multilevel Inverters and Converters
- Integrated Circuits and Semiconductor Failure Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Polyoxometalates: Synthesis and Applications
- Immune cells in cancer
Sun Yat-sen University
2022-2024
State Key Laboratory of Oncology in South China
2023-2024
Sun Yat-sen Memorial Hospital
2022-2024
Qiqihar University
2023
Sun Yat-sen University Cancer Center
2022-2023
Wuhan University
2021-2022
Renmin Hospital of Wuhan University
2021-2022
China University of Mining and Technology
2021
Cancer-associated fibroblasts (CAFs) exhibit considerable heterogeneity in advanced cancers; however, the functional annotation and mechanism of CAFs early-stage cancers remain elusive. Utilizing single-cell RNA sequencing spatial transcriptomic, we identify a previously unknown PDGFRα+ITGA11+ CAF subset bladder cancer (BCa). Multicenter clinical analysis 910-case cohort confirms that are associated with lymphovascular invasion (LVI) poor prognosis BCa. These facilitate LVI lymph node (LN)...
Circular RNAs (circRNA) containing retained introns are normally sequestered in the nucleus. Dysregulation of cellular homeostasis can drive their nuclear export, which may be involved cancer metastasis. However, mechanism underlying circRNA export and its role lymph node (LN) metastasis bladder remain unclear. Here, we identify an intron-retained circRNA, circNCOR1, that is significantly downregulated LN metastatic negatively associated with poor prognosis patients. Overexpression circNCOR1...
The tetraspanin protein superfamily participate in the dynamic regulation of cellular membrane compartments expressed a variety tumor types, which may alter biological properties cancer cells such as cell development, activation, growth and motility. role 7 (TSPAN7) has never been investigated bladder (BCa). In this study, we aimed to investigate function TSPAN7 its therapeutic potential human BCa. First, via reverse transcription quantitative real-time PCR (qRT-PCR), observed downregulation...
Abstract Heterogeneous extracellular vesicles (EVs) from various types of tumours are acknowledged for inducing the formation pre‐metastatic “niches” in draining lymph nodes (LNs) to promote lymphatic metastasis. In order identify specific subpopulations EVs involved, we performed high‐resolution proteomic analysis combined with nanoflow cytometry bladder cancer (BCa) tissue‐derived a novel subset tumour‐derived that contain integrin α6 (ITGA6 + EVs) and revealed positive correlation ITGA6...
Considering its speedy development and extremely low 5-year overall survival rate worldwide, bladder cancer (BCa) is one of the most common highly malignant tumors. Increasing evidence suggests that protein-coding mRNAs non-coding RNAs, including long RNAs (lncRNAs) micro (miRNAs), play an essential role in regulating biological processes cancer. To investigate molecular regulation associated with poor prognosis during advanced BCa development, we constructed a competitive endogenous RNA...
Abstract Aberrant gene expression is a prominent feature of metastatic cancer. Translational initiation vital step in fine-tuning expression. Thus, exploring translation regulators may identify therapeutic targets for preventing and treating metastasis. Herein, we identified that DHCR24 was overexpressed lymph node (LN) bladder cancer correlated with poor prognosis patients. promoted lymphangiogenesis LN metastasis vitro vivo. Mechanistically, mediated recognized the SUMO2 modification at...
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<div>Abstract<p>Aberrant gene expression is a prominent feature of metastatic cancer. Translational initiation vital step in fine-tuning expression. Thus, exploring translation regulators may identify therapeutic targets for preventing and treating metastasis. Herein, we identified that DHCR24 was overexpressed lymph node (LN) bladder cancer correlated with poor prognosis patients. promoted lymphangiogenesis LN metastasis <i>in vitro</i> vivo</i>....
<p>Table S1-S5 and Supplemental methods.</p>
<p>Figure S2</p>
<p>Figure S4</p>
<p>Figure S6</p>
<p>Figure S8</p>
<p>Figure S5</p>
<p>Figure S2</p>
<p>Figure S9</p>
<p>Figure S5</p>
<p>Table S1-S5 and Supplemental methods.</p>
<p>Figure S4</p>
<div>Abstract<p>Aberrant gene expression is a prominent feature of metastatic cancer. Translational initiation vital step in fine-tuning expression. Thus, exploring translation regulators may identify therapeutic targets for preventing and treating metastasis. Herein, we identified that DHCR24 was overexpressed lymph node (LN) bladder cancer correlated with poor prognosis patients. promoted lymphangiogenesis LN metastasis <i>in vitro</i> vivo</i>....
<p>Figure S3</p>
<p>Figure S8</p>