A5025651661- RNA modifications and cancer
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Lymphatic System and Diseases
- NF-κB Signaling Pathways
- Systemic Sclerosis and Related Diseases
- Vascular Malformations and Hemangiomas
- Immune cells in cancer
- Computational Geometry and Mesh Generation
- interferon and immune responses
- Growth Hormone and Insulin-like Growth Factors
- Electromagnetic Scattering and Analysis
- Advanced Antenna and Metasurface Technologies
- Glioma Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Helicobacter pylori-related gastroenterology studies
- Cancer Cells and Metastasis
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
Sun Yat-sen University
2013-2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Guangdong Academy of Medical Sciences
2025
Wuhan University
2024
Sun Yat-sen Memorial Hospital
2023-2024
State Key Laboratory of Oncology in South China
2017-2024
Key Laboratory of Guangdong Province
2017
Cancer-associated fibroblasts (CAFs) exhibit considerable heterogeneity in advanced cancers; however, the functional annotation and mechanism of CAFs early-stage cancers remain elusive. Utilizing single-cell RNA sequencing spatial transcriptomic, we identify a previously unknown PDGFRα+ITGA11+ CAF subset bladder cancer (BCa). Multicenter clinical analysis 910-case cohort confirms that are associated with lymphovascular invasion (LVI) poor prognosis BCa. These facilitate LVI lymph node (LN)...
Abstract Heterogeneous extracellular vesicles (EVs) from various types of tumours are acknowledged for inducing the formation pre‐metastatic “niches” in draining lymph nodes (LNs) to promote lymphatic metastasis. In order identify specific subpopulations EVs involved, we performed high‐resolution proteomic analysis combined with nanoflow cytometry bladder cancer (BCa) tissue‐derived a novel subset tumour‐derived that contain integrin α6 (ITGA6 + EVs) and revealed positive correlation ITGA6...
Intestinal farnesoid X receptor (FXR) antagonists have been proven to be efficacious in ameliorating metabolic diseases, particularly for the treatment of dysfunction-associated steatohepatitis (MASH). All reported FXR target ligand-binding pocket (LBP) receptor, whereas antagonist acting on non-LBP site nuclear (NR) is conceived as a promising strategy discover novel antagonist. Here, we postulated hypothesis antagonizing by disrupting interaction between and coactivators, successfully...
Background: Osteosarcopenia, the coexistence of osteoporosis and sarcopenia, poses significant challenges in aging populations due to its dual impact on bone muscle health. Inflammation, mediated by specific cytokines, is thought play a crucial role development osteosarcopenia, though underlying mechanisms are not fully understood. Objective: This study aimed clarify causal circulating cytokines pathogenesis osteosarcopenia employing mendelian randomization (MR) single-cell RNA sequencing...
Abstract Aberrant gene expression is a prominent feature of metastatic cancer. Translational initiation vital step in fine-tuning expression. Thus, exploring translation regulators may identify therapeutic targets for preventing and treating metastasis. Herein, we identified that DHCR24 was overexpressed lymph node (LN) bladder cancer correlated with poor prognosis patients. promoted lymphangiogenesis LN metastasis vitro vivo. Mechanistically, mediated recognized the SUMO2 modification at...
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<div>Abstract<p>Aberrant gene expression is a prominent feature of metastatic cancer. Translational initiation vital step in fine-tuning expression. Thus, exploring translation regulators may identify therapeutic targets for preventing and treating metastasis. Herein, we identified that DHCR24 was overexpressed lymph node (LN) bladder cancer correlated with poor prognosis patients. promoted lymphangiogenesis LN metastasis <i>in vitro</i> vivo</i>....
<p>Table S1-S5 and Supplemental methods.</p>
<p>Figure S2</p>
<p>Figure S4</p>
<p>Figure S6</p>
<p>Figure S8</p>
<p>Figure S5</p>
<p>Figure S2</p>
<p>Figure S9</p>
<p>Figure S5</p>
<p>Table S1-S5 and Supplemental methods.</p>
<p>Figure S4</p>
<div>Abstract<p>Aberrant gene expression is a prominent feature of metastatic cancer. Translational initiation vital step in fine-tuning expression. Thus, exploring translation regulators may identify therapeutic targets for preventing and treating metastasis. Herein, we identified that DHCR24 was overexpressed lymph node (LN) bladder cancer correlated with poor prognosis patients. promoted lymphangiogenesis LN metastasis <i>in vitro</i> vivo</i>....
<p>Figure S3</p>
<p>Figure S8</p>
<p>Figure S1</p>