A5030811440- Cell Adhesion Molecules Research
- Chemokine receptors and signaling
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Protease and Inhibitor Mechanisms
- Bone health and treatments
- Medical Imaging and Pathology Studies
- Immune Cell Function and Interaction
- Advanced Breast Cancer Therapies
- Calcium signaling and nucleotide metabolism
- interferon and immune responses
- CAR-T cell therapy research
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Mycotoxins in Agriculture and Food
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Synthesis and Biological Evaluation
- Adenosine and Purinergic Signaling
- Orthopaedic implants and arthroplasty
University of Würzburg
2022-2025
Guangzhou Medical University
2024-2025
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2015-2024
State Key Laboratory of Oncology in South China
2022
Heinrich Heine University Düsseldorf
2020-2021
First Affiliated Hospital of Jinan University
2019-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2018
Suzhou Institute of Systems Medicine
2016-2018
Soochow University
2013-2017
Abstract Although treatment with immune checkpoint inhibitors provides promising benefit for patients cancer, optimal use is encumbered by high resistance rates and requires a thorough understanding of mechanisms. We observed that tumors treated PD-1/PD-L1 blocking antibodies develop through the upregulation CD38, which induced all-trans retinoic acid IFNβ in tumor microenvironment. In vitro vivo studies demonstrate CD38 inhibits CD8+ T-cell function via adenosine receptor signaling or...
Abstract Mice are some of the widely used experimental animal models for studying human diseases. Defining compositions immune cell populations in various tissues from mouse is critical to understanding involvement responses physiological and patho-physiological conditions. However, non-lymphoid normally composed vast diverse cellular components, which make it difficult quantify relative proportions types. Here we report development a computational algorithm, ImmuCC, infer 25 types using...
The RNA sequencing approach has been broadly used to provide gene-, pathway- and network-centric analyses for various cell tissue samples. However, thus far, rich cellular information carried in samples not thoroughly characterized from RNA-Seq data. Therefore it would expand our horizons better understand the biological processes of body by incorporating a cell-centric view transcriptome. Here computational model named seq-ImmuCC was developed infer relative proportions 10 major immune...
Abstract Cooperation between primary malignant cells and stromal can mediate the establishment of lung metastatic niches. Here, we characterized landscape cell populations in tumor microenvironment treatment-naïve osteosarcoma using single-cell RNA sequencing identified a stem cell–like cluster with cell–initiating properties prometastatic traits. CXCL14 was specifically enriched also significantly upregulated metastases compared tumors. induced reprogramming evoked phenotype fibroblasts to...
Resveratrol, a natural polyphenol compound, has broad effects on critical events, including inflammation, oxidation, cancer and aging. However, the function molecular mechanisms of resveratrol T cell activation are controversial. In present study, we found that significantly inhibits cytokine production cells in vitro vivo. Sirt1 expression was up-regulated resveratrol-treated cells. Once down-regulated cells, resveratrol-induced inhibition noticeably diminished. The acetylation c-Jun...
Abstract The high heterogeneity and severe side effects of chemotherapy are major factors contributing to the failure osteosarcoma treatment. Herein, a comprehensive genomic analysis is conducted, identified two prominent characteristics osteosarcoma: significant cyclin‐dependent kinases 4 (CDK4) amplification homologous recombination repair deficiency. Based on these findings, co‐delivery system loaded with CDK4/6 inhibitors poly ADP‐ribose polymerase (PARP) designed. By employing...
Paradoxically, early host responses to infection include the upregulation of antiphagocytic molecule, CD47. This suggests that CD47 blockade could enhance antigen presentation and subsequent immune responses. Indeed, mice treated with anti-CD47 monoclonal antibody following lymphocytic choriomeningitis virus infections show increased activation both macrophages dendritic cells (DCs), enhancement kinetics potency CD8+ T cell responses, significantly improved control. Treatment efficacy is...
Beauvericin (BEA), a cyclic depsipeptide, is mycotoxin of the enniatin family and secondary metabolite various toxigenic fungi. Multiple biological functions BEA have been well investigated, such as anti-cancer, anti-inflammatory, anti-microbial, immune-activating functions. In recent study, we showed that can target Toll-like receptor 4 (TLR4) to induce dendritic cell (DC) activation. an in silico screen, identified Cathepsin B (CTSB) potential additional interaction partner for BEA, which...
T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated receive the paracrine signals required for their differentiation once they have disengaged from DCs and resumed migration has been unclear. We identified a distinct favors CD8 expressing receptors high affinity antigen. CXCR3 expression was hours-long reengagement in specific subfollicular niches lymph nodes. CD4 paused briefly at sites of DC provided...
Abstract The F-box proteins were originally identified as the key component of SKP1-Cullin1-F-box E3 ligase complexes that control stability their specific downstream substrates essential for cell growth and survival. However, involvement these in type I IFN (IFN-I) signaling during innate immunity has not been investigated. In this study we report protein FBXO17 negatively regulates IFN-I triggered by double-strand DNA, RNA, or viral infection. We found specifically interacts with...
Nickel-titanium (NiTi) alloy is a widely utilized medical shape memory (SMA) known for its excellent effect and superelasticity. Here, laser powder bed fusion (LPBF) technology was employed to fabricate porous NiTi scaffold featuring topologically optimized dominant cellular structure that demonstrates favorable physical superior biological properties. Utilizing topology optimization method informed by the stress state of human bones, two types structures-compression torsion-were designed,...
Background Recent evidence shows that long non-coding RNA (LncRNA) play important regulatory roles in many biology process, including cell development, activation and oncogenesis. However, the of these LncRNAs development CD4+ T cells, which is an component immune response, remain unknown. Results To predict function LncRNA first, we examined expression profiles mRNAs CD4−CD8− (DN), CD4+CD8+ (DP), CD4+CD8−, activated CD4+CD8− cells a microarray analysis verified results by real time PCRs...
Cancer-related cytokines may interfere with the differentiation and migration of dendritic cells (DCs) associated up-regulation co-stimulatory molecules in vitro. We determined whether affected distribution activation DCs patients colorectal cancer by measuring levels serum [transforming growth factor (TGF)-beta1 vascular endothelial (VEGF)], DC numbers phenotype from peripheral blood mesenteric lymph nodes draining cancer, infiltration into cancer. A significant increase level TGF-beta1...
The reconstruction of peripheral nerves has lately received great attention as many patients suffer from nerve injury every year around the world. However, damage to human cells different degrees irreversibility due a slow growth speed and low adhesion with surrounding tissues. In an effort overcome this challenge, we applied novel laminin (LN)-modified thiolated gellan gum (TGG) loaded factor (NGF) tissue engineering scaffold for facilitating neuronal stem cell proliferation via synergy...
Abstract Emerging evidence indicates B-cell activating factor (BAFF, Tnfsf13b) to be an important cytokine for antitumor immunity. In this study, we generated a BAFF-overexpressing B16.F10 melanoma cell model and found that BAFF-expressing tumors grow more slowly in vivo than control tumors. The tumor microenvironment (TME) of had decreased myeloid infiltrates with lower PD-L1 expression. Monocyte depletion anti-PD-L1 antibody treatment confirmed the functional importance monocytes phenotype...
Abstract Huge efforts have been devoted to develop therapeutic monoclonal antibodies targeting human Programmed death-ligand 1 (hPD-L1) for treating various types of cancers. However, thus far there is no suitable animal model evaluating the anti-tumor efficacy such against hPD-L1. Here we report generation a robust and effective system utilizing hPD-L1-expressing mouse tumor cells study activity mode action anti-human PD-L1 in mice. The has validated by using clinically proven hPD-L1...
Infections can result in a temporarily restricted unresponsiveness of the innate immune response, thereby limiting pathogen control. Mechanisms such are well studied lipopolysaccharide tolerance; however, whether mechanisms tolerance limit immunity during virus infection remains unknown. Here, we find that with highly cytopathic vesicular stomatitis (VSV) leads to anergy for several days. Innate is associated induction apoptotic cells, which activates Tyro3, Axl, and Mertk (TAM) receptor...
Minimally invasive separation surgery (MISS) is a safe and effective surgical technique, the current optimal treatment for spinal metastases. However, learning curve this technique has not been analyzed. This study aimed to define analyze of MISS metastases with small incision freehand pedicle screw fixation.A continuous series 62 patients who underwent were included. Each patient's operative data accurately counted. The improvement patients' neurological function was followed up after...