A5092620022- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
University of Würzburg
2025
Indian Institute of Technology Kanpur
2023
Abstract Chemokine receptors constitute an important subfamily of G protein-coupled (GPCRs), and they are critically involved in a broad range immune response mechanisms. Ligand promiscuity among these makes them interesting target to explore multiple aspects biased agonism. Here, we comprehensively characterize two chemokine namely, CXCR4 CXCR7, terms their transducer-coupling downstream signaling upon stimulation by common agonist, CXCL12, small molecule VUF11207. We observe that CXCR7...
T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated receive the paracrine signals required for their differentiation once they have disengaged from DCs and resumed migration has been unclear. We identified a distinct favors CD8 expressing receptors high affinity antigen. CXCR3 expression was hours-long reengagement in specific subfollicular niches lymph nodes. CD4 paused briefly at sites of DC provided...