A5100646341- Receptor Mechanisms and Signaling
- Proteins in Food Systems
- Computational Drug Discovery Methods
- Polysaccharides Composition and Applications
- Metal complexes synthesis and properties
- Neuropeptides and Animal Physiology
- Protein Structure and Dynamics
- T-cell and B-cell Immunology
- Polysaccharides and Plant Cell Walls
- Chemokine receptors and signaling
- Protein Interaction Studies and Fluorescence Analysis
- Metabolomics and Mass Spectrometry Studies
- Cholesterol and Lipid Metabolism
- Heat Transfer and Optimization
- Food Industry and Aquatic Biology
- Liver Disease Diagnosis and Treatment
- Food Chemistry and Fat Analysis
- Drug Transport and Resistance Mechanisms
Nanjing University of Finance and Economics
2024
Jilin University of Chemical Technology
2024
Institute of Chemical Technology
2024
McGill University
2021-2023
Abstract Chemokine receptors constitute an important subfamily of G protein-coupled (GPCRs), and they are critically involved in a broad range immune response mechanisms. Ligand promiscuity among these makes them interesting target to explore multiple aspects biased agonism. Here, we comprehensively characterize two chemokine namely, CXCR4 CXCR7, terms their transducer-coupling downstream signaling upon stimulation by common agonist, CXCL12, small molecule VUF11207. We observe that CXCR7...
G protein–coupled receptors engage both proteins and β-arrestins, their coupling can be biased by ligands mutations. Here, to resolve structural elements mechanisms underlying effector the angiotensin II (AngII) type 1 receptor (AT1R), we combined alanine scanning mutagenesis of entire sequence with pharmacological profiling Gα q β-arrestin engagement mutant molecular dynamics simulations. We showed that AT1R involved a large number residues spread across receptor, whereas fewer regions...
To promote efficient conversion of lignocellulose to humus (HS) during composting, a novel bio-electrochemical technology was applied and explore the effect mechanism electrification on carbon different composting periods. The results showed that supplementary electric field played roles composting. In early stage, organic matter mineralization significantly accelerated under application, embodied in 29.8% increase CO2 emission due enhanced metabolic activity microorganisms. However,...
Heat exchanger network is one of the major technique energy conservation. This article synthesizes heat exchange network, through adjusting bypass exchanger, flexibility and redundancy control system can be effectively improved, which conducive to forming a closed-loop final temperature, thereby improving quality stability system. The matching relationship selected qualitative analysis operating characteristics coupling loops, reduces degree between loops in engineering design stage....
Abstract The allosteric communication between the agonist binding site and G protein or β-arrestin coupling sites in protein-coupled receptors (GPCRs) play an important role determining ligand efficacy towards these two signaling pathways hence bias. Knowledge of amino acid residue networks involved will aid understanding GPCR design biased ligands. Angiotensin II type I receptor (AT1R) is ideal model to study molecular basis bias as it has multiple β-arrestin2 Gq agonists well...