A5103154654- Computational Drug Discovery Methods
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Cancer-related gene regulation
- Pharmacogenetics and Drug Metabolism
- Protein Hydrolysis and Bioactive Peptides
- Plant biochemistry and biosynthesis
- Probiotics and Fermented Foods
- Protein Interaction Studies and Fluorescence Analysis
- Gut microbiota and health
- Nutrition, Health and Food Behavior
- Synthesis and bioactivity of alkaloids
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Proteins in Food Systems
- Mercury impact and mitigation studies
- Herbal Medicine Research Studies
- Air Quality and Health Impacts
- Liver physiology and pathology
- Metal complexes synthesis and properties
- Cholinesterase and Neurodegenerative Diseases
- Insect Utilization and Effects
- Food and Agricultural Sciences
- Plant chemical constituents analysis
- Berberine and alkaloids research
Nankai University
2024
Nanjing University of Finance and Economics
2021-2024
Tianjin University of Traditional Chinese Medicine
2021-2023
Shandong Provincial QianFoShan Hospital
2020
Shandong University
2017-2020
The molecular that used as prognosis and potential therapy target is urgently needed in hepatocellular carcinoma (HCC). In current work, we found the expression of CHAD (chondroadherin) was significantly reduced compared to normal tissue, on both mRNA protein levels, three independent datasets. Survival analysis implemented these datasets, low be associated with poor survival. Furthermore, metastasis-averse HCC metastasis-incline group comparison, abundance evaluation normal-tumor-portal...
Network pharmacology was used to illuminate the targets and pathways of polybrominated diphenyl ethers (PBDEs) causing thyroid dysfunction. A protein-protein interaction (PPI) network constructed. Molecular docking applied analyze PBDEs key according results. total 247 were found be related 16 PBDEs. Ten with direct action identified, including top five PIK3R1, MAPK1, SRC, RXRA, TP53. Gene Ontology (GO) functional enrichment analysis identified 75 biological items. Kyoto Encyclopedia Genes...
Xuanfei Baidu granule (XFBD) is a recommended patented drug for the prevention and treatment of Corona Virus Disease 2019 (COVID-19), which approved by National Medical Products Administration. XFBD suppresses over-activated immune response caused inflammatory factor storms in COVID-19 infection. The intestine plays crucial role system. mass spectrometry based fecal metabolomics with 16S rDNA sequencing were combined to evaluate effects on host metabolism gut microbiome. Short-chain fatty...
Hepatocyte nuclear factor 4 α (HNF‑4α) is a receptor and mediates hepatic genes. WB‑F344 liver epithelial cells can differentiate into hepatocytes. The present study aimed to examine the roles mechanisms of action HNF‑4α on differentiation cells. were divided normal cell group (WB‑F344), empty vector (PLKO), gene silencing (PLKO‑SH). expression levels measured using reverse transcription‑quantitative polymerase chain reaction analysis. Proliferation was determined Cell Counting kit‑8 assay....
Marein is the main active compound of Coreopsis tinctoria Nutt., and its activities include antioxidant, hypoglycemic, hypotensive. After oral administration marein, blood concentration marein low. The metabolites have not been reported systematically. In this study, a rapid systematic method based on ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) was established to detect in vivo (plasma urine) after injection. Sixty-one were...
This study aimed to elucidate the inhibition mechanism of apigenin against porcine pancreatic lipase (PPL), and, moreover, comprehensively reveal molecular basis its anti-obesity via network pharmacology approach. The results showed that inhibited PPL with an IC 50 value 0.377±0.041 mM. Spectroscopic techniques combined docking suggested could bind into active pocket, affecting normal spatial conformation. Moreover, dynamic (MD) simulations revealed open conformation tended transit closed in...
Coreopsis tinctoria Nutt. (family Asteraceae) is a popular medicine-food plant, which improves chronic diseases such as hyperlipemia, hypertension, and diabetes. Flavanomarein the main active component of Nutt, in blood concentration volunteers low bioavailability poor. Thus, understanding flavanomarein metabolites metabolic pathways significant to clarify its effectiveness. This study systematically studied by oral injection. The biological samples (feces, urine, plasma) were analyzed...
Abstract Introduction Coptidis Rhizoma (CR) is one of the most frequently used herbs to treat ulcerative colitis (UC) and often processed before usage. However, composition changes therapeutic effects CR after processing in treatment UC are still unclear. Objective The purpose study explore chemical components crude CR. Material methods was according 2020 version Chinese Pharmacopoeia. liquid chromatography–mass spectrometry (LC–MS) multivariate statistical analysis were screen different...