A5101679277- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Pineapple and bromelain studies
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Neurobiology of Language and Bilingualism
- Postharvest Quality and Shelf Life Management
- Plant tissue culture and regeneration
- Circadian rhythm and melatonin
- Migraine and Headache Studies
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Bioactive Compounds
- Dementia and Cognitive Impairment Research
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Plant responses to elevated CO2
- Geothermal Energy Systems and Applications
- Genomics, phytochemicals, and oxidative stress
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
Baotou Medical College
2018-2024
East Carolina University
2008-2024
Guangzhou First People's Hospital
2007-2024
Guangzhou Medical University
2007-2024
Third Affiliated Hospital of Southern Medical University
2024
South China Botanical Garden
2006-2023
Jishou University
2023
Chinese Academy of Sciences
2006-2023
Zhejiang Chinese Medical University
2023
South China University of Technology
2017-2023
Breast cancer (BC) is the most prevalent malignant neoplasm among women and fifth common cause of cancer-associated death worldwide. Acquired chemoresistance driven by genetic epigenetic alterations a significant clinical challenge in treating BC. However, mechanism BC cell resistance to adriamycin (ADR) remains be elucidated. In this study, we identified methyltransferase-like 3/microRNA-221-3p/homeodomain-interacting protein kinase 2/Che-1 (METTL3/miR-221-3p/HIPK2/Che-1) axis as novel...
Abstract Background Expression and activity of the fibroblast growth factor (FGF) 21 hormone-like protein are associated with development several metabolic disorders. This study was designed to investigate whether serum FGF21 level also syndrome-related cardiovascular disease, atherosclerosis, its clinical features in a Chinese cohort. Methods Two-hundred-and-fifty-three subjects visiting Cardiology Department (Sixth People's Hospital affiliated Shanghai JiaoTong University) were examined by...
Aims Accumulating evidence suggest that numerous microRNAs (miRNAs) play important roles in cell proliferation, apoptosis, and differentiation, as well various diseases accompany inflammatory responses. Inflammation is known to be a major contributor atherogenesis. Previous studies provide promising support of the role miRNAs cardiovascular disease. However, mechanistic data on these small molecules atherosclerosis (AS) are still missing. The present study aims investigate potential AS....
Fibroblast growth factor (FGF) 21, a hormone primarily secreted by liver, has recently been shown to have beneficial effects on glucose and lipid metabolism insulin sensitivity in animal models. This study investigated the association of serum FGF21 levels with secretion sensitivity, as well circulating parameters hepatic enzymes Chinese subjects.Serum were determined ELISA 134 normal tolerance (NGT), 101 isolated-impaired fasting glucose, 118 (I-IGT) subjects, their adiposity, profiles,...
There is increasing evidence that microRNAs (miRNAs) play important roles in cell proliferation, apoptosis and differentiation accompany inflammatory responses. However, whether miRNAs are associated with dendritic (DC) immuno-inflammatory responses to oxidized low density lipoprotein (oxLDL) stimulation yet unknown. Our study aims explore the link of miRNA lipid-overload mechanism for atherosclerosis. Human primary monocyte-derived DCs were transfected miR-146a mimics inhibitor, then...
Microglia become activated during neuroinflammation and produce neurotoxic neurotrophic factors, depending on whether they acquire M1 proinflammatory or M2 anti-inflammatory phenotypes. Astaxanthin (ATX), a natural carotenoid, has neuroprotective effects. We investigated ATX could reverse M1/M2 polarization suppress via low-density lipoprotein receptor-related protein-1 (LRP-1). observed increased expression of (TNF-α, IL-1β, CD86) decreased (Arg-1, IL-10, CD206) markers in BV2 microglial...
5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for breast cancer treatment. Although aberrant expression of protein-coding genes was observed after 5-FU treatment, the regulatory mechanism remains poorly understood. MicroRNAs (miRNAs) are newly identified class small RNAs which play an important role in gene regulation at post-transcriptional levels. Recent evidence suggests miRNAs initiation, progression, and metastasis human cancers. In this study, using...
The large nitrate transporter 1/peptide family (NPF) has been shown to transport diverse substrates, including nitrate, amino acids, peptides, phytohormones, and glucosinolates. However, the rice (Oryza sativa) root-specific member OsNPF7.2 not functionally characterized. Here, our data show that is a tonoplast localized low-affinity transporter, affects growth under high supply. Expression analysis showed was mainly expressed in elongation maturation zones of roots, especially root...
Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis during adulthood. Here, we show that TCS induces toxicity in both the nematode C. elegans human mesenchymal stem cells (hMSCs) by disrupting SKN-1/Nrf2-mediated oxidative stress response. Specifically, exposure affected survival hMSC proliferation dose-dependent manner. Cellular analysis showed inhibited nuclear localization of...
Abstract Warming may have profound effects on nitrogen (N) cycling by changing plant N demand and underground supply. However, large uncertainty exists regarding how warming affects the integrated dynamic in tropical forests. We translocated model plant‐soil ecosystems from a high‐altitude site (600 m) to low‐altitude sites at 300 30 m simulate 1.0°C 2.1°C, respectively, China. The of experimental components plant, soil, leaching, gas were studied over 6 years. Our results showed that foliar...
N6-methyladenosine (m6A) methyltransferase METTL3 has been implicated in carcinogenesis, which may be associated the overexpression of MALAT1. However, downstream mechanics actions remain largely unknown. This study intends to probe mechanism (m6 A) and MALAT1 adriamycin resistance breast cancer. Through Bioinformatics databases lncMAP, TCGA GTEx, we predicted transcription factors E2F1 AGR2 The Cancer Genome Atlas Genotype-Tissue Expression (GTEx) were used screen target genes MeRIP-qPCR...
Complex figure copying is a commonly used neuropsychological test. Here we explored the neural basis of factors underlying complex (CFC), using data from Birmingham Cognitive Screen (BCoS) in large group sub-acute, ischemic stroke patients (239). We computed two analyses: first assessed contribution co-morbid deficits (i.e. gesture processing, object use, visual neglect, pictures naming and sustained attention) to lesions associated with CFC. In second analysis Principle Component Analysis...
Drug resistance in breast cancer (BC) cells continues to be a stern obstacle hindering BC treatment. Adriamycin (ADR) is frequently employed chemotherapy agent used treat BC. The exosomal transfer of microRNAs (miRNAs) has been reported enhance the drug-resistance cells. Herein, we first sought elucidate possible role miR-221-3p drug MCF-7 ADR. Differentially expressed genes (DEGs) were initially screened through microarray analysis resistance-related datasets. Next, expression and...
Abstract Interventions to improve working memory, e.g. by combining task rehearsal and non-invasive brain stimulation, are gaining popularity. Many factors, however, affect the outcome of these interventions. We hypothesize that memory capacity at baseline predicts how an individual performs on a task, setting limits benefit derived from tDCS when combined with strategy instructions; specifically, we individuals low will most. Eighty-four participants underwent two sessions adaptive (n-back)...