A5051554573- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Selenium in Biological Systems
- Parkinson's Disease Mechanisms and Treatments
- CRISPR and Genetic Engineering
- GABA and Rice Research
- Reproductive Biology and Fertility
- Pharmacological Effects of Natural Compounds
- Alzheimer's disease research and treatments
- Nanoparticles: synthesis and applications
- Cholinesterase and Neurodegenerative Diseases
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Rabbits: Nutrition, Reproduction, Health
- Natural product bioactivities and synthesis
- Medicinal Plants and Neuroprotection
- Tryptophan and brain disorders
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
- Phytochemical compounds biological activities
- Liver physiology and pathology
- Coenzyme Q10 studies and effects
Korea University of Science and Technology
2024-2025
Korea Research Institute of Standards and Science
2024-2025
Woosuk University
2014-2024
East Carolina University
2011-2018
Reactive oxygen species (ROS) are generated during normal metabolic processes under aerobic conditions. Since ROS production initiates harmful radical chain reactions on cellular macromolecules, including lipid peroxidation, DNA mutation, and protein denaturation, it has been implicated in a wide spectrum of diseases such as cancer, cardiovascular disease, ischemia-reperfusion aging. Over the past several decades, antioxidants have received explosive attention regarding their protective...
Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis during adulthood. Here, we show that TCS induces toxicity in both the nematode C. elegans human mesenchymal stem cells (hMSCs) by disrupting SKN-1/Nrf2-mediated oxidative stress response. Specifically, exposure affected survival hMSC proliferation dose-dependent manner. Cellular analysis showed inhibited nuclear localization of...
Human hepatic organoids (hHOs) are regarded as physiologically relevant in vitro platforms to evaluate hepatotoxicity, a critical step drug development, but their applications currently limited by the lack of qualified and standardized evaluation markers. In this study, leveraging established reference measurement system amino acids (AAs), we propose 12 new biomarkers for drug-induced hepatotoxicity human induced pluripotent stem cell–derived hHOs. Two orthogonal analytical methods AAs were...
Catalpol is an effective component of rehmannia root and known to possess various pharmacological properties. The present study was aimed at investigating the potential effects catalpol on lifespan stress tolerance using C. elegans model system. Herein, showed potent extension wild-type nematode under normal culture condition. In addition, survival rate catalpol-fed nematodes significantly elevated compared untreated control heat oxidative but not hyperosmolality conditions. We also found...
The seed of Vigna angularis has long been cultivated as a food or folk medicine in East Asia. Genistein (4',5,7-trihydroxyisoflavone), dietary phytoestrogen present this plant, known to possess various biological properties. In study, we investigated the possible lifespan-extending effects genistein using Caenorhabditis elegans model system. We found that lifespan nematode was significantly prolonged presence under normal culture condition. addition, elevated survival rate against stressful...
Resveratrol (RSV) extends the lifespan of various organisms through activation sirtuin. However, whether RSV-mediated longevity is entirely dependent upon sirtuin still controversial. Thus, understanding additional mechanisms concerning genetic requirements for biological activity RSV needs to be clarified utilize beneficial effects RSV. In this study using Caenorhabditis elegans as a model system, we found that MPK-1 (an ERK homolog) signaling necessarily required sir-2.1/sirtuin mutants...
Bisphenol A (BPA), a widespread environmental contaminant, poses concerns due to its disruptive effects on physiological functions of the uterine endometrium. In contrast, melatonin (MT) and Resveratrol (RSV) are under scrutiny for their potential protective roles against BPA-induced damage. For efficacy ethical in animal test, endometrial organoids, three-dimensional models mimicking endometrium, serve as crucial tools unraveling impact factors reproductive health. This study aimed...
Several theories emphasize that aging is closely related to oxidative stress and disease.The formation of excess ROS can lead DNA damage the acceleration aging.Vigna angularis one important medicinal plants in Korea.We isolated vitexin from V. elucidated lifespan-extending effect using Caenorhabditis elegans model system.Vitexin showed potent lifespan extensive activity it elevated survival rates nematodes against stressful environments including heat conditions.In addition, our results was...
The twigs of Sorbus alnifolia (Sieb. et Zucc.) K. Koch (Rosaceae) have been used to treat neurological disorders as a traditional medicine in Korea. However, there are limited data describing the efficacy S. Parkinson's disease (PD).
Abies koreana Wilson (A. koreana) is a shrub or broadly pyramidal evergreen tree endemic in the mountainous regions of South Korea. We obtained essential oil (EO) from alpine needle leaves A. by supercritical fluid extraction (SFE) method. EO was analyzed gas chromatography–mass spectrometry (GC–MS), and 68 compounds were identified constituting 95.66% oil. The major components elemol (11.17%), terpinen-4-ol (9.77%), sabinene (8.86%), 10(15)-cadien-4-ol (7.16%), α-terpineol (6.13%), α-pinene...
Notch receptor signaling is a highly conserved cell communication system in most multicellular organisms and plays critical role at several junctures animal development. In Caenorhabditis elegans,GLP-1/Notch essential for both germline stem maintenance germ proliferation during gonad Here, we show that subunits (POLA-1, DIV-1, PRI-1, PRI-2) of the DNA polymerase alpha-primase complex are required response to GLP-1/Notch different tissues developmental stages. Specifically, genetic functional...
The gut microbiome influences drug metabolism and therapeutic efficacy. Still, the lack of a general label-free approach for monitoring bacterial or host metabolic contribution hampers deeper insights. Here, 2D nuclear magnetic resonance (NMR) is introduced that enables real-time Levodopa (L-dopa), an anti-Parkinson drug, in both live bacteria bacteria-host (Caenorhabditis elegans) symbiotic systems. quantitative method reveals discrete Enterococcus faecalis substrains produce different...
Here in this study, we investigated the lifespan-extending effect and underlying mechanism of methanolic extract Moringa olelifa leaves (MML) using Caenorhabditis elegans (C. elegans) model system. To define longevity properties MML conducted lifespan assay showed significant increase under normal culture condition. In addition, elevated stress tolerance C. to endure against thermal, oxidative osmotic conditions. Our data also revealed that increased activities antioxidant enzymes...