Islam M. Saadeldin

ORCID: 0000-0002-7633-730X
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About
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Research Areas
  • Reproductive Biology and Fertility
  • Sperm and Testicular Function
  • Extracellular vesicles in disease
  • Animal Nutrition and Physiology
  • Pluripotent Stem Cells Research
  • Animal Genetics and Reproduction
  • Reproductive System and Pregnancy
  • Reproductive Physiology in Livestock
  • Animal Diversity and Health Studies
  • Renal and related cancers
  • Rabbits: Nutrition, Reproduction, Health
  • MicroRNA in disease regulation
  • Bee Products Chemical Analysis
  • Selenium in Biological Systems
  • Ovarian function and disorders
  • Heat shock proteins research
  • Tissue Engineering and Regenerative Medicine
  • Effects of Environmental Stressors on Livestock
  • Genetic and phenotypic traits in livestock
  • Moringa oleifera research and applications
  • CRISPR and Genetic Engineering
  • Meat and Animal Product Quality
  • Diet and metabolism studies
  • Nanoparticles: synthesis and applications
  • Adipose Tissue and Metabolism

King Faisal Specialist Hospital & Research Centre
2020-2025

Alfaisal University
2025

King Saud University
2016-2024

Chungnam National University
2021-2024

Zagazig University
2015-2024

Jeonbuk National University
2021

Universidade Federal Rural do Semi-Árido
2020

Seoul National University
2011-2015

Catholic University of Daegu
2012

It is well known that embryos cultured in a group can create microenvironment through secretion of autocrine and paracrine factors support improve the embryos' development when compared to individually. In this study, we used co-culture system for communication between different kinds embryos. The results showed porcine parthenogenetic (PA) significantly improved vitro cloned (nuclear transfer, NT) To reveal possible mechanism two groups, isolated exosomes/microvesicles (EXs/MVs) from PA...

10.1089/cell.2014.0003 article EN Cellular Reprogramming 2014-04-28

Cross talk, mediated by exosomes, between normal stem cells and cancer (CSCs) in the tumor microenvironment has been given less attention so far. In addition, no publications are available literature that address vivo impact of exosomes derived from CSCs mesenchymal (MSCs) on progression long-term hepatocellular carcinoma (HCC). Herein, we hypothesized transfer among HCC could either induce or inhibit growth metastasis depending their source. To check this hypothesis, investigated effect...

10.1155/2018/8058979 article EN cc-by Stem Cells International 2018-08-27

Abstract: A myriad of locally produced factors into the microenvironment reproductive tract is regulated, not one-way but rather, through embryonic–maternal cross-talk. In this minireview, we focused on exosomes, which are cell-derived vesicles 30–100 nm in diameter, as a communicating language facilitating dialog. These nanovesicles secreted from preimplantation embryos, oviduct epithelium, and endometrium well placenta, contain proteins, messenger RNA (mRNA), microRNA, DNA cargoes, have...

10.2147/sccaa.s84991 article EN cc-by-nc Stem Cells and Cloning Advances and Applications 2015-07-01

The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role vitamins C E were examined. Two hundred males held aquaria (10 fishes/aquarium). Fishes divided into 5 groups: 40 fishes each group; first group was control; 2nd 3rd groups exposed to 1 2 mg/L ZnONPs, respectively; 4th 5th ZnONPs treated with a (500 mg/kg diet) mixture vitamin (250 diet each). Muscles collected 7th 15th day treatments. Muscle malondialdehyde, reduced glutathione...

10.1155/2018/6926712 article EN cc-by Oxidative Medicine and Cellular Longevity 2018-01-01

Objective The current study aimed to replace soybean oil in broiler diets with linseed oil, which is rich omega-3 fatty acid supplemented pomegranate peel extract (PPE) and measured its effect on performance, carcass traits, lipid profile, as well acids composition, phenols flavonoids content of muscles immunity chicks. Methods A total 300 1-day-old Cobb chicks were randomly allotted into six experimental groups, T1 fed basal diet without any additives, T2 addition 0.5 g/kg PPE, T3 1 T4 T5...

10.5713/ajas.18.0522 article EN cc-by Asian-Australasian Journal of Animal Sciences 2019-01-03

The present study investigated the toxic impacts of lead (LD) on productive and reproductive performances Japanese quails role Yucca schidigera extract (YSE) in reducing these impacts. A total 360 mature (at 2 months age) were used experiment was lasted for 8 wk. birds divided into 6 equal groups as follows: control (basal diet), basal diet + 100 mg LD/kg diet, YSE (100 mg/kg (200 LD diet) diet). resulted a significant decrease feed intake (FI), conversion ratio (FCR), egg production...

10.3382/ps/pey186 article EN cc-by-nc-nd Poultry Science 2018-05-26

Zinc oxide nanopartciles (ZnONPs) involved in advanced technologies, and their wide-scale use consumer market makes human beings more prone to the exposure ZnONPs. The present study was undertaken evaluate amelioration of ZnONP-induced toxicities with querectin male albino rats. ZnONPs-treated rats showed a significant decrease sperm cell count, motility, live normal sperms, as well serum testosterone level. Severe histopathological damage increase lipid peroxidation antioxidant enzymes...

10.1002/jbt.21812 article EN Journal of Biochemical and Molecular Toxicology 2016-04-25

There are several obstacles in camel semen cryopreservation; such as increasing viscosity and the reduction motile spermatozoa after ejaculation. Epididymal offer an efficient alternative to overcome these problems well-suited for artificial insemination camels. In current study, we compared effects of supplementation with vitamin C, E, inorganic trace elements selenium (Na2SeO3) zinc (ZnSO4), nanoparticles (ZnONPs SeNPs, respectively) on cryopreservation dromedary epididymal spermatozoa....

10.3390/ani10010078 article EN cc-by Animals 2020-01-02

The objective of this study was to evaluate the effects quantitative feed restriction, along with dietary supplementation a probiotic blend (Protexin) as natural growth promoter, on performance, water consumption, mortality rate and carcass traits meat-type quails. A total 250 1-day unsexed quails were randomly allocated five equal groups in completely randomized design. first group (A) fed basal diet without any restriction (24 hr/day); second (B1) for 20 hr/day; third (B2) enriched (0.1...

10.1111/asj.13290 article EN Animal Science Journal 2019-08-29

The present study aimed to examine the impacts of supplementation red or black pepper oils rabbit diet as growth promoters on New Zealand white (NZW) rabbits. One hundred and forty weaned NZW rabbits were divided randomly into seven groups in a completely randomized experiment using different quantities oil (RPO; 0.5, 1.0, 1.5 g/kg diet) (BPO; diet), addition control group. Compared control, values live body weight (LBW) for fed either RPO BPO enriched diets greater. concentrations serum...

10.3390/ani8100168 article EN cc-by Animals 2018-10-02

The effects of rutin on growth performance, hematological and biochemical profiles, antioxidant capacity, economics the relative expression selected antioxidants lipid-related genes were studied in broiler chickens over 42 days. A total 200 one-day-old female Ross-308 distributed into four groups, with five replicates 10 individuals per replicate. They fed 0 (control), 0.25, 0.5 or 1 g rutin/kg supplementation their basal diet. Dietary supplementation, especially g/kg diet, increased body...

10.3390/ani9010007 article EN cc-by Animals 2018-12-22

The Arabian camel is the largest known mammal that can survive in severe hot climatic conditions. We provide molecular explanation for thermotolerance of granulosa somatic cells after exposure to 45 °C 2 (acute heat shock) or 20 h (chronic shock). common features cellular responses acute stress were increase shock proteins and DNA repair enzymes expression. Actin polymerization Rho signaling critically activated as a defense against shock. Cells exposed chronic showed altered cell...

10.1016/j.jare.2019.11.009 article EN cc-by-nc-nd Journal of Advanced Research 2019-11-22

Kisspeptin (Kp) is best known as a multifunctional peptide with roles in reproduction, the cardiovascular system and cancer. In present study expression of kisspeptin hierarchy elements (KISS1, GNRH1 LHB) their receptors (KISS1R, GNRHR LHCGR, respectively) porcine ovary cumulus-oocyte complexes (COCs) were investigated, its effects on vitro maturation (IVM) oocytes subsequent ability to sustain preimplantation embryo competence after parthenogenetic electrical activation. Kp expressed...

10.1071/rd11118 article EN Reproduction Fertility and Development 2011-11-28

Quercetin (QT) and taxifolin (TF) are structurally similar plant-derived flavonoids that have antioxidant properties act as free radical scavengers. The objective of this study was to investigate effects QT TF on nuclear maturation porcine oocytes. Effects at 0, 1, 10, 50 μg/mL oocyte (polar body extrusion) were investigated. After incubation for 44 h, there no significant differences between the treatment control groups except in group which significantly lower (59.2%, p<0.05) than other...

10.5713/ajas.15.0341 article EN cc-by Asian-Australasian Journal of Animal Sciences 2015-09-03

Newcastle disease is still causing huge economic losses and devastating outbreaks in poultry flocks despite implementation of extensive vaccination programs. Five commercial broiler chicken groups were established as G1 (non-vaccinated, non-challenged group) G2 challenged group), 3 vaccinated G3 (vaccinated with heterologous inactivated virus (NDV) genotype II (NDV II) vaccine), G4 homologous NDV VII VII) G5 bivalent (heterologous plus H5) vaccine) used. Challenge test was done using a...

10.3382/ps/pey559 article EN cc-by-nc-nd Poultry Science 2018-12-15

This study aimed to investigate the effect of using breeder parents (434-days-old) and broiler chickens (37 D age) from Ross 308 on meat quality parameters carcass characteristics; sex muscle type were also estimated. Carcass assessment involved hot weight, yield, cuts (breast, legs, wings, back, shoulder). A total 120 birds divided into 2 groups (60 each stock), stock contain equal number sexes (30 males 30 females), further 6 replicates, so that there 5 in replicate. The fed ad libitum....

10.3382/ps/pez464 article EN cc-by-nc-nd Poultry Science 2019-08-08
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