A5082352331- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Brucella: diagnosis, epidemiology, treatment
- Heat shock proteins research
- Bee Products Chemical Analysis
- Analytical Chemistry and Chromatography
- Bioinformatics and Genomic Networks
- Phenothiazines and Benzothiazines Synthesis and Activities
- Animal Diversity and Health Studies
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Methods in Pharmaceuticals
Children Cancer Hospital
2019-2022
Ain Shams University
2019-2020
The Arabian camel is the largest known mammal that can survive in severe hot climatic conditions. We provide molecular explanation for thermotolerance of granulosa somatic cells after exposure to 45 °C 2 (acute heat shock) or 20 h (chronic shock). common features cellular responses acute stress were increase shock proteins and DNA repair enzymes expression. Actin polymerization Rho signaling critically activated as a defense against shock. Cells exposed chronic showed altered cell...
Metabolomics is a potential approach to paving new avenues for clinical diagnosis, molecular medicine, and therapeutic drug monitoring development. The conventional metabolomics analysis pipeline depends on the data-independent acquisition (DIA) technique. Although powerful, it still suffers from stochastic, non-reproducible ion selection across samples. Despite presence of different workbenches, metabolite identification remains tedious time-consuming task. Consequently, sequential windowed...
A SIMPLE, sensitive and reliable HPLC-MS/MS HPLC-UV methods were developed validated for Cis-and Trans-Cefprozil diastereoisomers determination in human plasma.The plasma samples subjected to protein precipitation after the addition of cephalexin as internal standard.Chromatographic separation was achieved using Waters Xbridge C18 column 5µm, 4.6×150mm maintained at 25° C. The method utilized MRM transitions; 390.1 208.1 348.1 158.2 Cefprozil cephalexindetection respectively, while...