A5029026193- Extracellular vesicles in disease
- Animal Nutrition and Physiology
- Reproductive Biology and Fertility
- Pluripotent Stem Cells Research
- Animal Genetics and Reproduction
- Reproductive System and Pregnancy
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Muscle Physiology and Disorders
- Salmonella and Campylobacter epidemiology
- Chemotherapy-induced organ toxicity mitigation
- Biomedical Ethics and Regulation
- Inflammatory Bowel Disease
- Andrographolide Research and Applications
- Nigella sativa pharmacological applications
- NF-κB Signaling Pathways
- Livestock and Poultry Management
- Nanoparticles: synthesis and applications
- CRISPR and Genetic Engineering
- Acute Myeloid Leukemia Research
- TGF-β signaling in diseases
- Zebrafish Biomedical Research Applications
- Moringa oleifera research and applications
Zagazig University
2017-2024
Zewail City of Science and Technology
2019-2024
Universitat de Lleida
2010
Cross talk, mediated by exosomes, between normal stem cells and cancer (CSCs) in the tumor microenvironment has been given less attention so far. In addition, no publications are available literature that address vivo impact of exosomes derived from CSCs mesenchymal (MSCs) on progression long-term hepatocellular carcinoma (HCC). Herein, we hypothesized transfer among HCC could either induce or inhibit growth metastasis depending their source. To check this hypothesis, investigated effect...
The present study involved in vivo evaluation of the growth promoting effects thymol and nanoemulsion their protection against Salmonella Typhimurium infection broilers. One-day old 2400 chicks were randomly divided into eight groups; negative positive control groups fed basal diet without additives (0.25, 0.5 1% each). At d 23, all except challenged with S. Typhimurium. Over total growing period, birds showed better performance even after challenge, which came parallel upregulation...
Salmonella enterica serovar Typhimurium (S. typhimurium) is known for its intracellular survival, evading the robust inflammation and adaptive immune response of host. The emergence decreased ciprofloxacin (CIP) susceptibility (DCS) requires a prolonged antibiotic course with increased dosage, leading to threatening, adverse effects. Moreover, antibiotic-resistant bacteria can persist in biofilms, causing serious diseases. Hence, we validated vitro vivo efficacy ciprofloxacin-loaded...
Abstract Promising therapy is needed for treating inflammatory bowel diseases (IBD) to overcome current treatment that inefficient and associated with unnecessary health risks. Recently, the concept of incorporating natural products into nanocarriers has been intended as a promising IBD via modulating their stability bioavailability. Thus, we aimed explore potential alleviating effects dietary nano-supplement combined bacillus strains ( Bacillus amyloliquefaciens ; BANPs) in colitis model....
Gut modulation by multi-strain probiotics (MSPs) is considered an effective strategy for treating inflammatory bowel disease (IBD). The combination of nanomaterial-based MSPs can improve their viability and resistance allow targeted release in the gastrointestinal tract to be achieved. Thus, our aim investigate prospective role MSP integration into nanomaterials (MSPNPs) underlying molecular mechanisms supporting application as alternative therapy IBD using a colitis rat model. To induce...
The rate of chronic kidney disease (CKD) is increasing globally, and it caused by continuous damage to tissue. With time the renal becomes irreversible, leading CKD development. In females, post-menopause lack estrogen supply has been described as a risk factor for development, studies targeting are scarce. present study, we used exosomes isolated from bone marrow mesenchymal stem/stromal cells (BM-MSCs) test their therapeutic potential against development CKD. At first, menopause model was...
Background: We investigated the anti-cancer effect of carnosine-loaded niosomes (Car-NIO) and melittin-loaded (Mel-NIO) with olaparib in breast cancer cell lines (MCF-7 MDA-MB-231). Methods: The thin film method was used for preparing characterized terms morphology, size, polydispersity index (PDI). further evaluated impact these peptides on cells viability, RT-qPCR assays, malondialdehyde (MDA) activity, cycle progression, to determine if are linked carnosine melittin's anti-proliferative...
ABSTRACT This study aimed to determine the effectiveness of guanidinoacetic acid (GAA) with or without methionine (Met) compared creatine (CREA) at enhancing duck's performance, restoring tissue CREA and improving meat quality. Mulard ducklings (n = 250) were randomly assigned control (without additives), plus CREA, GAA, GAA + 0.2%Met (GAAMet0.2) 0.4%Met (GAAMet0.4) groups in a completely random experimental design. Dietary supplementation significantly increased (P < 0.05) overall weight...
Appropriate skeletal muscle development in poultry is positively related to increasing its meat production. Synthetic peptides with growth hormone-boosting properties can intensify the effects of endogenous hormones. However, their on mRNA and miRNA expression profiles that control post-hatching broiler chicks unclear. Thus, we evaluated possible synthetic peptide (GHBP) inclusion a chicken’s rate, development-related genes myomiRs, serum biochemical parameters, myofiber characteristics. A...
Background: 5-FU is an antimetabolic agent used for treating slowly growing solid tumors like breast and ovarian carcinoma. Thymoquinone (TQ) a main biologically active constituent of Nigella sativa, it has been found to demonstrate anticancerous effects in several preclinical studies, this because TQ possesses multi-target nature. Stem cells-derived exosomes are the spotlight research promising tissue regenerative anticancer cell-derived nanovesicles. Aim: Herein, we studied antineoplastic...
Autophagy is a key metabolic process where cells can recycle its proteins and organelles to regenerate own cellular building blocks. Chemotherapy indispensable for cancer treatment but associated with various side-effects, including organ damage. Stem cell-based therapy promising approach reducing chemotherapeutic side effects, however, one of main culprits the poor survival transplanted stem in damaged tissues. Here, we aimed test effects activating autophagy adipose-derived mesenchymal...
Trophectoderm cells are the foremost embryonic to differentiate with prospective stem-cell properties. In current study, we aimed at improving approach for trophoblast culture by using granulosa as feeders. Porcine (PGCs) compared conventional mouse fibroblasts (MEFs) were used grow trophectoderm from hatched bovine blastocysts. Isolated monitored and displayed characteristic epithelial/cuboidal morphology. The isolated expressed mRNA of homeobox protein (CDX2), cytokeratin-8 (KRT8),...
Bleomycin (BL) is a well-known anticarcinogenic chemotherapy that used for the remedy of numerous varieties most cancers. However, use BL became connected to prevalence several unfavorable results together with skin and lung fibrosis testicular cancer. Dietary micronutrients such as vitamin E, selenium (Se) are gambling critical roles in maintaining health human animals preserving cell redox status homeostasis through their antioxidant roles. The objectives current investigation had been...
Smart innovative nanocomposites based on active ingredients and metallic nanoparticles with effective wound healing antifungal properties are efficient in overcoming the limitations of traditional therapeutic products. Open wounds provide an ideal niche for colonization by
This study aimed at evaluating the effect of acidifying additives as formic and propionic acids on weight gain small intestinal macroscopic, microscopic SEM morphology in ducks. A total 30 Mulard ducklings were used this they randomly assigned to control (given standard commercial duck diets with no acidifiers added), 1% added diet or 2% diet. After rearing ducks for 52 days, their was recorded then length different parts intestine measured. Then, samples taken histological scanning electron...