A5029340518- Antibiotics Pharmacokinetics and Efficacy
- Coccidia and coccidiosis research
- Veterinary medicine and infectious diseases
- Microbial infections and disease research
- Trace Elements in Health
- Pneumonia and Respiratory Infections
- Inflammasome and immune disorders
- Antibiotic Resistance in Bacteria
- Advanced Nanomaterials in Catalysis
- Drug-Induced Hepatotoxicity and Protection
- Genomics, phytochemicals, and oxidative stress
- Inflammatory Bowel Disease
- Aquaculture Nutrition and Growth
- Moringa oleifera research and applications
- Aquaculture disease management and microbiota
- Nanoparticles: synthesis and applications
- Cancer-related cognitive impairment studies
- Bee Products Chemical Analysis
- Liver physiology and pathology
- Phytochemistry and Bioactivity Studies
- Pharmacological Effects and Toxicity Studies
- Heavy Metal Exposure and Toxicity
- Acute Kidney Injury Research
- Pharmaceutical studies and practices
- Rabbits: Nutrition, Reproduction, Health
Mansoura University
2016-2025
University of Veterinary Medicine
2021
Obihiro University of Agriculture and Veterinary Medicine
2020
Iowa State University
2017-2018
The aim of this study was to evaluate the removal Pb (II) and Ni from untreated waste water using sugarcane bagasse possible desorption metal ions adsorbent for effective re-use. effects pH (4-6), temperature (30-70 °C), contact time (30-150 min) dosage (0.3-0.7 g) were examined. Optimum conditions efficiencies (89.31 %) (96.33 pH, 6.0; temperature, 30 °C; time, 90 min. dosage, 0.5 g. maximum monolayer adsorption capacities 1.61 mg/g 123.46 respectively, by fitting equilibrium data Langmuir...
Salmonella enterica serovar Typhimurium (S. typhimurium) is known for its intracellular survival, evading the robust inflammation and adaptive immune response of host. The emergence decreased ciprofloxacin (CIP) susceptibility (DCS) requires a prolonged antibiotic course with increased dosage, leading to threatening, adverse effects. Moreover, antibiotic-resistant bacteria can persist in biofilms, causing serious diseases. Hence, we validated vitro vivo efficacy ciprofloxacin-loaded...
Abstract Promising therapy is needed for treating inflammatory bowel diseases (IBD) to overcome current treatment that inefficient and associated with unnecessary health risks. Recently, the concept of incorporating natural products into nanocarriers has been intended as a promising IBD via modulating their stability bioavailability. Thus, we aimed explore potential alleviating effects dietary nano-supplement combined bacillus strains ( Bacillus amyloliquefaciens ; BANPs) in colitis model....
Among commonly consumed anti-inflammatory and antimicrobial drugs are diclofenac sodium (DFS) oxytetracycline (OTC), especially in developing countries because they highly effective cheap. However, the concomitant administration of with antibiotics may exaggerate massive toxic effects on many organs. Cinnamon (Cinnamomum zeylanicum, Cin) is considered one most broadly utilized plants various antioxidant actions. This study aimed to evaluate possible protective cinnamon aqueous extract (Cin)...
Pulmonary fibrosis (PF) is a life-threatening disorder with very poor prognosis. Because of the complexity PF pathological mechanisms, filling such an unmet medical need challenging. A number pulmonary diseases have been linked to activation NF-κB and NLRP3 inflammasome. Coomassie brilliant blue G-250 (CBBG) proved be safe highly selective P2×7R antagonist promising consequent inactivation This first report investigate effect CBBG on bleomycin-induced lung in rats. Our findings revealed that...
Gut modulation by multi-strain probiotics (MSPs) is considered an effective strategy for treating inflammatory bowel disease (IBD). The combination of nanomaterial-based MSPs can improve their viability and resistance allow targeted release in the gastrointestinal tract to be achieved. Thus, our aim investigate prospective role MSP integration into nanomaterials (MSPNPs) underlying molecular mechanisms supporting application as alternative therapy IBD using a colitis rat model. To induce...
Ulcerative colitis (UC), an inflammatory bowel disease, is a chronic condition of multifaceted pathophysiology. The incidence UC increasing internationally. current therapies for lack relative effectiveness and are associated with adverse effects. Therefore, novel therapeutic options should be developed. It has been well documented that modulating the Nrf2/NFκB promising target in inflammation. Carbocisteine mucoregulatory medication its efficacy COPD was found to more closely related...
Introduction As a growing direction, nano-based therapy has become successful paradigm used to address the phytogenic delivery-related problems in overcoming multivirulent vancomycin-resistant Staphylococcus aureus (VRSA) infection. Methods Hence, our aim was develop and assess novel nanocarrier system (mesoporous silica nanoparticles, MPS-NPs) for free berberine (Free-BR) as an antimicrobial alkaloid against strong biofilm-producing multi-virulent VRSA strains using vitro vivo mouse model....
Origanum majorana L. is a member of the Lamiaceae family and commonly used in Egyptian cuisine as seasoning flavor enhancer. It also recognized well-known traditional medicine Egypt widely for treating abdominal colic due to its antispasmodic properties. However, protective effects against ulcerative colitis underlying mechanisms remain unclear.This study aimed identify biologically active components present methanol extracts using gas chromatography/mass spectrometry (GC/MS). Additionally,...
Chemofog is a serious sequela commonly manifested among cancer patients receiving doxorubicin (DOX) chemotherapy. Our goal was to explore the abrogative action of α-Bisabolol (BISA), phytochemical sesquiterpene, against DOX-induced cognitive deficit. Rats were allocated into 5 groups: Group I: control; II received BISA orally (100 mg/kg/day for 4 weeks); III DOX (2 mg/kg/week/i.p.) weeks; Groups IV and V administered at 50 100 mg/kg, respectively plus DOX, i. p. Results: 1) attenuated...
Candida albicans infection induces economic losses in aquaculture practices. Currently, the success of nanotechnology field has gained more consideration sector as it bestows favorable impacts remedies comparison to traditional The present study was conducted assess role nano chitosan gel (NCG) exposure via water managing deteriorating triggered by C. Nile tilapia, Oreochromis niloticus. Hepato-renal function, behavioral and stress response, neurological hepatic antioxidant/oxidant status,...
Ischemia is a major contributor to acute kidney injury (AKI), for which current treatment options remain limited. One NAD+-dependent deacetylase that can preserve renal cells SIRT1. To date, no research has directly explored the effects of E1231, SIRT1 activator, in context ischemia-reperfusion (IR) injury. Enhancing NAD+ levels essential sustaining activity. Hence, combined use E1231 and SR647, precursor, could potentially amplify protective by supporting prolonged activation. This study...
Cyanidin is a natural anthocyanidin present in fruits and vegetables with anti-diabetic properties including stimulation of insulin secretion. However, its mechanism action remains unknown. In this study, we elucidated the mechanisms cyanidin for stimulatory secretion from pancreatic β-cells. Rat β-cells INS-1 were used to investigate effects on secretion, intracellular Ca2+ signaling, gene expression. We detected presence space stimulated increased signals concentration-dependent manner....
Glycation of proteins is often considered as a method to improve their functional properties for promising applications in wound healing. Furthermore, marked increase percentage radical scavenging activity the conjugates makes it an effective antioxidant synthetic strategy. A simple conjugation process was employed develop bovine serum albumin-dextran (BSA-dextran) using Maillard reaction. Higher electrophoretic mobility and surface charge prepared observed native PAGE electrophoresis zeta...
Climate change is considered to be the primary cause of heat stress (HS) in broiler chickens. Owing unique properties extracted polyphenols, resveratrol-loaded liposomal nanoparticles (Resv-Lipo NPs) were first explored mitigate harmful effects HS. The dietary role Resv-Lipo NPs heat-stressed birds was investigated based on their growth performance, antioxidative potential, and expression shock proteins, sirtuins, antioxidant, immune, muscle-building related genes. A total 250 1-day-old Ross...
Respiratory diseases inflicted by Mycoplasma gallisepticum (MG) and Ornithobacterium rhinotracheale (ORT) cause severe economic losses great burden to the poultry industry worldwide. Therefore, current study was planned assess efficacy of aivlosin alone or in combination with zinc oxide nanoparticles (ZnO-NPs) treatment experimental MG and/or ORT infections broilers. Moreover, we also aimed evaluate role ZnO-NPs on residues broiler tissues. A total 1,440 Cobb chicks were allocated into 6...
Chemo fog is one of the most serious health concerns encountered by cancer survivors receiving doxorubicin (DOX)-based chemotherapy. Oxidative stress, neuroinflammation, apoptosis and impairment synaptic plasticity are regarded as key factors implicated in DOX-induced cognitive impairment. This research aimed to assess possible neuroprotective effect cerium oxide nanoparticles (CeNPs) against neurotoxicity. Forty-eight rats were divided into four groups (12 rats/group): control group, CeNPs...