A5089855305- Metabolism, Diabetes, and Cancer
- Heat shock proteins research
- Nicotinic Acetylcholine Receptors Study
- Inflammasome and immune disorders
- Vagus Nerve Stimulation Research
- Pancreatic function and diabetes
- IL-33, ST2, and ILC Pathways
- Genomics, phytochemicals, and oxidative stress
- Atrial Fibrillation Management and Outcomes
- FOXO transcription factor regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiovascular Function and Risk Factors
- Receptor Mechanisms and Signaling
- Endoplasmic Reticulum Stress and Disease
- ATP Synthase and ATPases Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neurological Disorders and Treatments
- Inhalation and Respiratory Drug Delivery
- Hedgehog Signaling Pathway Studies
- Alcohol Consumption and Health Effects
- Ginger and Zingiberaceae research
- Flavonoids in Medical Research
- Adenosine and Purinergic Signaling
Delta University for Science and Technology
2020-2024
Suez Canal University
2019
Hepatocellular carcinoma (HCC) is the third foremost cause of cancer-related deaths. HCC has a very bad prognosis because it asymptomatic in early stages, resulting late diagnosis, and highly resistant to conventional chemotherapy. Such chemotherapies have been proven disappointing they provide extremely low survival benefits. This study discloses that STAT3/HIF-1α an auspicious therapeutic attack site for conceivable repression development. A can be targeted by simultaneous administration...
Empagliflozin and metformin are widely used for the treatment of type 2 diabetes. These drugs showed marked anti-inflammatory effects in different animal models via enhancing AMPK activity. Yet, protective their combination against ulcerative colitis have not been previously investigated. The current study aimed to explore potential empagliflozin/metformin mitigate DSS-induced rat model. modulating empagliflozin on AMPK/mTOR/NLRP3 axis T cell polarization were delineated. In this study,...
Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology that increases the risk developing colorectal cancer and imposes lifelong healthcare burden on millions patients worldwide. Current treatment strategies are associated with significant risks have been shown to be fairly effective. Hence, discovering new therapies better efficacy safety profiles than currently exploited therapeutic challenging. It has well delineated NF‐κB/Nrf2 crosstalk chief player...
Pulmonary fibrosis (PF) is a life-threatening disorder with very poor prognosis. Because of the complexity PF pathological mechanisms, filling such an unmet medical need challenging. A number pulmonary diseases have been linked to activation NF-κB and NLRP3 inflammasome. Coomassie brilliant blue G-250 (CBBG) proved be safe highly selective P2×7R antagonist promising consequent inactivation This first report investigate effect CBBG on bleomycin-induced lung in rats. Our findings revealed that...
Hepatocellular carcinoma (HCC) is on the rise worldwide, and its incidence in diabetic patients two to three times that of non-diabetics. Current therapeutic options fail provide considerable survival benefits with HCC. There a strong possibility FDA-approved antidiabetic combination empagliflozin metformin could show complementary effects control HCC progression. However, their multitarget have not yet been studied development. Therefore, present study aims evaluate antitumorigenic activity...
Ulcerative colitis (UC), an inflammatory bowel disease, is a chronic condition of multifaceted pathophysiology. The incidence UC increasing internationally. current therapies for lack relative effectiveness and are associated with adverse effects. Therefore, novel therapeutic options should be developed. It has been well documented that modulating the Nrf2/NFκB promising target in inflammation. Carbocisteine mucoregulatory medication its efficacy COPD was found to more closely related...
HIF-1α is a key factor promoting the development of hepatocellular carcinoma (HCC). As well, AKT-AMPKα-mTOR signaling promising target for cancer therapy. Yet, AKT-AMPKα-mTOR-dependent activation has not been studied in livers with HCC. In addition, mechanisms underlying potential antineoplastic effects sitagliptin (STGPT), an antidiabetic agent, have yet elucidated. For that purpose, N-nitrosodiethylamine (NDEA)-induced HCC mouse model was used present study using dose 100 mg/kg/week, i.p.,...
Purpose: The NLRP3 inflammasome is a substantial component of the inflammation process. complex pathogenesis and implication vast number components in inflammasome-activation pathway prompted us to search for compounds that have wide therapeutic index act at level multiple cellular targets. Although CRID3 blocks with high specificity laboratory, clinical trials compound reported weaker potency. Methods: We used NSC328382, P2X7R antagonist, as an adjunctive therapy generated strategy...
Idiopathic pulmonary fibrosis is a fatal lung disorder in which the etiology and pathogenesis are still unobvious. Effective treatments urgently needed considering that transplantation only treatment could improve outcomes. This study aimed to investigate therapeutic significance of dual administration pimitespib, an HSP90 inhibitor, nifuroxazide, STAT3 against bleomycin-induced rats. Our results revealed pimitespib/nifuroxazide inhibited alterations structure function lungs. They...
The orexins, also referred to as hypocretins, are neuropeptides that originate from the lateral hypothalamus (LH) region of brain. They composed two small peptides, orexin-A, and orexin-B, which broadly distributed throughout central peripheral nervous systems. Orexins recognized regulate diverse functions, involving energy homeostasis, sleep-wake cycle, stress responses, reward-seeking behaviors. Additionally, it is suggested orexin-A deficiency linked sleepiness narcolepsy. orexins bind...
Non-alcoholic steatohepatitis (NASH) is characterized by liver inflammation, fat accumulation, and collagen deposition. Due to the limited availability of effective treatments, there a pressing need develop innovative strategies. Given complex nature disease, employing combination approaches essential. Hedgehog signaling has been recognized as potentially promoting NASH, cholesterol can influence this modifying conformation PTCH1 SMO activity. HSP90 plays role in stability GLI proteins. We...
Ulcerative colitis (UC) is a debilitating chronic disease marked by persistent inflammation and intestinal fibrosis. Despite the availability of various treatments, many patients fail to achieve long-term remission, underscoring significant unmet therapeutic need. BMS-477118, reversible inhibitor dipeptidyl peptidase 4 (DPP4), has demonstrated anti-inflammatory properties in preclinical clinical studies with minimal adverse effects compared other antidiabetic agents. However, potential...
Rheumatoid arthritis is an autoimmune disease that affects joints, leading to swelling, inflammation, and dysfunction in the joints. Recently, research efforts have been focused on finding novel curative approaches for rheumatoid arthritis, as current therapies are associated with adverse effects. Here, we examined effectiveness of dabigatran, antithrombotic agent, treating complete Freund’s adjuvant (CFA)-induced rats. Subcutaneous injection a single 0.3 mL dosage CFA into rat’s hind leg...
The development of new drugs for the inhibition hepatocellular carcinoma (HCC) and progression is a critical urgent need. median survival rate HCC patients remains disappointingly low. Vinpocetine safe nootropic agent that often used to enhance cognitive function. impact vinpocetine on has not been fully explored. Our main objective was investigate possible inhibitory role in rats exposed diethylnitrosamine. We observed increased these improved ultrastructure their livers. Additionally,...