A5038004701- Retinal Diseases and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug-Induced Hepatotoxicity and Protection
- Nerve injury and regeneration
- Nitric Oxide and Endothelin Effects
- Drug Transport and Resistance Mechanisms
- Adenosine and Purinergic Signaling
- Nicotinic Acetylcholine Receptors Study
- Pancreatic function and diabetes
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Function and Risk Factors
- Heme Oxygenase-1 and Carbon Monoxide
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Metal complexes synthesis and properties
- Selenium in Biological Systems
- Curcumin's Biomedical Applications
- Chemotherapy-induced organ toxicity mitigation
- Retinoids in leukemia and cellular processes
- Vagus Nerve Stimulation Research
- Retinal Development and Disorders
- Liver Disease Diagnosis and Treatment
Suez Canal University
2012-2022
University of Georgia
2011-2014
Augusta University
2012-2014
Discovery Institute
2011-2014
Charlie Norwood VA Medical Center
2013
Augusta University Health
2013
Epigallocatechin-gallate (EGCG) and resveratrol (RSVL) are two of the most promising natural medicines. We verified their capacity to ameliorate cisplatin (CP)-induced disruption renal glomerular filtration rate (GFR) in rats, sought mediatory involvement lipid peroxidation (malondialdehyde [MDA]-level) inflammatory cytokine (TNF-α) therein. CP (10 mg kg−1), a single i.p. dose, disrupted GFR (11-fold-rise proteinuria, 2–5-fold rise serum creatinine/urea levels) after 7 days, killed all...
Retinal neurodegeneration is an early and critical event in several diseases associated with blindness. Clinically, therapies that target fail. We aimed to elucidate the multiple roles by which thioredoxin-interacting protein (TXNIP) contributes initial sustained retinal neurodegeneration.Neurotoxicity was induced intravitreal injection of NMDA into wild-type (WT) TXNIP-knockout (TKO) mice. The expression apoptotic inflammatory markers assessed immunohistochemistry, elisa Western blot....
Our previous studies showed positive correlation between accumulation of proNGF, activation RhoA and neuronal death in diabetic models. Here, we examined the neuroprotective effects selective inhibition kinase rat retina a model that stably overexpressed cleavage-resistance proNGF plasmid retina. Male Sprague-Dawley rats were rendered using streptozotosin or express cleavage-resistant plasmid. The intravitreal injection inhibitor Y27632 vivo. Effects freshly isolated primary retinal ganglion...
Treatment of breast cancer with doxorubicin causes numerous side effects, which cardiac fibrosis is considered the main one. This study was designed to investigate underlying molecular mechanisms for potential anti-fibrotic effect pirfenidone and vitamin D against doxorubicin-induced fibrosis. Seventy mice carrying solid Ehrlich's ascites carcinoma (EAC) discs on ventral were treated orally administered (500 mg/kg) intraperitoneal injection (0.5 µg/kg) either individually or in combination a...
Myocardial infarction (MI) is one of the main causes morbidity and mortality in diabetic patients. The antidiabetic glucagon-like polypeptide-1 receptor (GLP-1R) agonists, such as exenatide, proved to confer cardioprotection; however, their exact mechanisms are not fully elucidated. Although cardioprotective effect α-estrogen (ERα) activation well established, its involvement exenatide-induced cardioprotection has never been investigated. Moreover, modulation insulin-like growth factor-1/2...
Objective To study the effect of hyperhydration with normal saline and frusemide on renal resistive index (RI) in children equivocal obstructive uropathy. Patients methods Twelve (24 kidneys) unilateral or bilateral hydronephrosis underwent isotopic diuretic renography Doppler ultrasonography. All had obstruction hydronephrotic kidneys half‐time drainage (T/2) values 10–20 min. studies were carried out both at baseline after infusion frusemide. Results Of 24 kidneys, five 19 hydronephrotic;...
Diabetic retinopathy (DR), the most feared complication of diabetes, compromises vision and quality life approximately 50 million people worldwide, with its prevalence projected to double by 2025 [101]. DR, leading cause blindness in working-age adults USA, is characterized early neurodegeneration, glial activation vascular injury, which includes breakdown blood–retina barrier (BRB) acellular capillary formation that eventually leads retinal neo-vascularization (reviewed [1]). Interestingly,...