A5018203813- Liver physiology and pathology
- Cancer-related Molecular Pathways
- Gut microbiota and health
- Hedgehog Signaling Pathway Studies
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Heat shock proteins research
- Aldose Reductase and Taurine
- Adipose Tissue and Metabolism
- Problem and Project Based Learning
- Innovative Teaching Methods
- Mitochondrial Function and Pathology
- Cytokine Signaling Pathways and Interactions
- Gastroesophageal reflux and treatments
- FOXO transcription factor regulation
- Bone Metabolism and Diseases
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- Wnt/β-catenin signaling in development and cancer
- Artificial Intelligence in Healthcare and Education
- Medical Education and Admissions
- Clinical Reasoning and Diagnostic Skills
University of Bisha
2022-2025
Idiopathic pulmonary fibrosis (IPF) is an irreversible and life-threatening lung disease of unknown etiology presenting only a few treatment options. TGF-β signaling orchestrates cascade events driving (PF). Notably, recent research has affirmed the augmentation receptor (TβR) via HSP90 activation. HSP90, molecular chaperone, adeptly stabilizes folds TβRs, thus intricately regulating TGF-β1 signaling. Our investigation illuminated impact alvespimycin, inhibitor, on TGF-β-mediated...
Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal area that demonstrates dramatically increasing incidence worldwide. This study provides novel insights into capacity exogenous β-hydroxybutyrate and ketogenic diet (KD) consumption to alleviate dextran sodium sulfate (DSS)-induced UC in rats. Remarkably, both interventions attenuated activity colon weight-to-length ratio, improved macro microstructures damaged colon. Importantly, KD curbed DSS-induced...
Sedentary lifestyles, urbanization and improvements in socio-economic status have had serious effects on the burden of diabetes across world. Diabetes is one 10 leading causes death globally, individuals with a 2-3-fold increased risk all-cause mortality. Adipose tissue increasingly understood as highly active endocrine gland that secretes many biologically substances, including adipocytokines. However, exact discrete pathophysiological links between obesity T2DM are not yet fully...
Sorafenib, a multikinase inhibitor, is first-line treatment for advanced hepatocellular carcinoma, but its long-term effectiveness limited by the emergence of resistance mechanisms. One such mechanism reduction microvessel density and intratumoral hypoxia caused prolonged sorafenib treatment. Our research has demonstrated that HSP90 plays critical role in conferring to HepG2 cells under hypoxic conditions N-Nitrosodiethylamine-exposed mice as well. This occurs through inhibition necroptosis...
Liver fibrosis is a progressive condition characterized by the build-up of fibrous tissue resulting from long-term liver injury. Although there have been advancements in research and treatment, still need for effective antifibrotic medication. HSP90 plays crucial role development fibrosis. It acts as molecular chaperone that assists proper folding stability TβRII, potentially regulating signaling TGF-β1. has established TβRII can be degraded through proteasome degradation system, either via...
Student-centered learning strategy increases the likelihood of graduation competent, self-dependent, and problem-solving physicians. The University Bisha, College Medicine (UBCOM) adopted self-directed (SDL) represented by problem-based (PBL), directed self-learning (DSL) team-based (TBL).
Abstract Accumulating evidence suggests that dysregulation of FOXO3a plays a significant role in the progression various malignancies, including hepatocellular carcinoma (HCC). inactivation, driven by oncogenic stimuli, can lead to abnormal cell growth, suppression apoptosis, and resistance anticancer drugs. Therefore, emerges as potential molecular target for development innovative treatments era oncology. Linagliptin (LNGTN), DPP‐4 inhibitor known its safe profile, has exhibited noteworthy...
Ulcerative colitis is a chronic and incurable form of inflammatory bowel disease that can increase the risk colitis-associated cancer mortality. Limited treatment options are available for this condition, existing ones often come with non-tolerable adverse effects. This study first to examine potential benefits consuming (R,R)-BD-AcAc2, type ketone ester (KE), intermittent fasting in treating induced by dextran sodium sulfate (DSS) rats. We selected both protocols enhance levels...
Background: Identifying the potential factors of depression among medical students is first step towards academic excellence and future safe practice. Methods: A cross-sectional study was conducted from December 2019 to February 2020 at University Bisha, College Medicine (UBCOM), Bisha Province, Saudi Arabia. Male year one six were involved. self-administered questionnaire used collect data about students’ socio-demographic characteristics. The Arabic version PHQ-9 scale with a score ≥10...
Non-alcoholic steatohepatitis (NASH) is characterized by liver inflammation, fat accumulation, and collagen deposition. Due to the limited availability of effective treatments, there a pressing need develop innovative strategies. Given complex nature disease, employing combination approaches essential. Hedgehog signaling has been recognized as potentially promoting NASH, cholesterol can influence this modifying conformation PTCH1 SMO activity. HSP90 plays role in stability GLI proteins. We...
BackgroundBronchial asthma is a persistent inflammatory respiratory condition that restricts the passage of air and causes hyperresponsiveness. Chronic can be classified into three categories: mild, moderate, severe. Remodeling took place as extracellular matrix accumulated in walls airways. Inflammation occurs result damage caused by metalloproteinase-2 (MMP-2) to basement membrane type IV collagen. The severity may associated with miR-196a2. objective our study was investigate underlying...
Sorafenib is a multikinase inhibitor employed for managing hepatocellular carcinoma (HCC). The emergence of sorafenib resistance presents an obstacle to its therapeutic efficacy. One notable approach overcoming the exploration combination therapies. role hedgehog signaling in has been also examined HCC. R51211, known as itraconazole, safely clinical practice. Through vitro and vivo investigations, we assessed potential R51211 enhance efficacy by inhibiting signaling. zero-interaction potency...
The development of new drugs for the inhibition hepatocellular carcinoma (HCC) and progression is a critical urgent need. median survival rate HCC patients remains disappointingly low. Vinpocetine safe nootropic agent that often used to enhance cognitive function. impact vinpocetine on has not been fully explored. Our main objective was investigate possible inhibitory role in rats exposed diethylnitrosamine. We observed increased these improved ultrastructure their livers. Additionally,...
One of the most prevalent metabolic illnesses is diabetes mellitus. oral symptoms that has a significant effect on quality life xerostomia. Unfortunately, current methods for alleviating or resolving dry mouth are largely poor and only provide palliative care at best. This highlights need novel approaches to treating xerostomia in diabetic patients. The present study aimed assess ameliorative effects agmatine salivary glands' histological biochemical alteration streptozotocin (STZ)-induced...
Background: Hypertension imposes a significant public health burden. An increased awareness of hypertension complications within population can positively impact patient care and prevent complications. This study seeks to assess the among Bisha in Saudi Arabia 2020. Methods: A cross-sectional was conducted validated self-administered online-based questionnaire sent sample adult measure their Results: Almost three-quarters (72.2%) were aware The level significantly higher male participants (p...