A5033591343- Phytochemistry and Biological Activities
- Hydrogen's biological and therapeutic effects
- Natural Antidiabetic Agents Studies
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Ethnobotanical and Medicinal Plants Studies
- Traditional and Medicinal Uses of Annonaceae
- Ginger and Zingiberaceae research
- Diet and metabolism studies
- Diabetic Foot Ulcer Assessment and Management
- Pharmacological Effects of Natural Compounds
- Phytochemistry and biological activities of Ficus species
- Alkaloids: synthesis and pharmacology
- Natural Compound Pharmacology Studies
- Berberine and alkaloids research
- Chemokine receptors and signaling
- MicroRNA in disease regulation
- Parasitic infections in humans and animals
- COVID-19 epidemiological studies
- Pharmacological Effects and Toxicity Studies
- Moringa oleifera research and applications
- Nigella sativa pharmacological applications
- Selenium in Biological Systems
- Bioactive natural compounds
- Circular RNAs in diseases
University of Bisha
2018-2024
Kano State University of Technology
2022
King Abdullah Medical City
2022
Vanderbilt University Medical Center
2022
King Fahd Medical City
2022
Ahmadu Bello University
2014-2020
Usmanu Danfodiyo University
2019
University of Pretoria
2014-2018
Onderstepoort Veterinary Academic Hospital
2014-2016
Introduction: There is a growing interest in studying natural products for the identification of novel lead compounds drug development treating inflammatory diseases. Although some studies have focused anti-inflammatory activity benzophenones and xanthones, exploring additional targets such as enzymes cytokines, involved their response could provide more comprehensive understanding compounds’ effects. In this study, four xanthones ananixanthone ( 1 ), smeathxanthone A 2 B 3...
Strychnos spinosa Lam. is a deciduous tree used in traditional medicine to treat infectious diseases. This study designed determine the antimicrobial, antioxidant and cytotoxic activities of extracts fractions from leaves S. spinosa. Extracts were obtained by maceration with acetone, methanol dichloromethane/methanol (1/1) while prepared liquid-liquid fractionation acetone extract. A broth serial microdilution method tetrazolium violet as growth indicator was minimum inhibitory concentration...
Abstract Accumulating evidence suggests that dysregulation of FOXO3a plays a significant role in the progression various malignancies, including hepatocellular carcinoma (HCC). inactivation, driven by oncogenic stimuli, can lead to abnormal cell growth, suppression apoptosis, and resistance anticancer drugs. Therefore, emerges as potential molecular target for development innovative treatments era oncology. Linagliptin (LNGTN), DPP‐4 inhibitor known its safe profile, has exhibited noteworthy...
Preliminary phytochemical screening of the ethanol leaves of Cissampelos mucronata revealed presence reducing sugars, cardiac glycosides, resin, tannins, saponins, flavonoids, glycerin and steroids. The median lethal dose (LD50) in rats is greater than 5000 mg/kg body weight intaperitoneally. hypoglycemic effect extract of C. mucronata was also investigated Streptozocin- induced diabetic rats. Single intraperitoneally administration at doses 200, 400 800 mg/kg. There was a significant...
BackgroundBronchial asthma is a persistent inflammatory respiratory condition that restricts the passage of air and causes hyperresponsiveness. Chronic can be classified into three categories: mild, moderate, severe. Remodeling took place as extracellular matrix accumulated in walls airways. Inflammation occurs result damage caused by metalloproteinase-2 (MMP-2) to basement membrane type IV collagen. The severity may associated with miR-196a2. objective our study was investigate underlying...
Cordia africana (Boraginaceae) is a tree used in traditional medicine to treat inflammation related conditions and infectious diseases. This study was undertaken with the objectives of establishing scavenging effect extracts fractions Codia on mediator Lipoxygenases (LOX), some non-biological free radicals such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), [2, 2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid)] (ABTS) Ferric ion reducing antioxidant power (FRAP). Antimicrobial activities, total...
The study was aimed at determining the anti-inflammatory activity of fractions and extracts obtained from Strychnos spinosa leaves on a mediator inflammation nitric oxide (NO).Leaves were extracted with acetone separated into different polarities by solvent-solvent fractionation. Griess assay used to determine (NO) inhibitory activity. Cellular toxicity determined "using MTT reduction assay".With exception ethyl acetate fraction which had an IC50 >750 μg/mL, all significant oxide-inhibitory...
Background: Like many other academic programs, medical education is incomplete without a robust assessment plan. Objective: The study aimed to evaluate the impact of longitudinal faculty development program (FDP) on examination item quality (EIQ) from cohort college members. Methods: Item analysis (IA) multiple-choice questions (MCQs) tutors over 3-year period (2017 [S1], 2018 [S2], and 2019 [S3]) before following once-per-week FDP was conducted. were three randomly selected courses: man his...
Disorders of smell are generally difficult to diagnose and treat, often because a lack knowledge understanding this sense its disease state. An alteration in may be life threatening at times like impairment detection smoke fire. Anosmia can occur through exposure environmental toxins. Exposure toxins accounts for 1- 5% all olfactory disorders. A case report sudden anosmia as result accidental “otapiapia”, local organophosphate based pesticide is presented.
The aim of this study was to determine, using meta-analysis, the prevalence diabetes mellitus (DM) and explore influence method diagnosis, DM types, year on with view evaluating trend burden in KSA. Prevalence estimates were derived a random effect model carefully selected population-based studies applied total populations country give an estimated DM. Twenty-one studies, 376,998 participants out whom 54,837 had DM, selected. 20.9%, 0.9%, 12.6% for T2DM, T1DM, combined T1/T2DM, respectively....
The abortifacient role of aqueous extract Vernoniaamygdalina was investigated by measuring the serum progesterone levels experimental animals. 20 female albino rats were grouped into four groups (n=5). Vaginal smear taken every morning and viewed under microscope. Rats in their pro- estrous cycle paired with males vaginal next to confirm pregnancy. Group I treated normal saline, group II received 200μg/ml standard drug (Misoprostol) III IV 250mg 500mg/ml V. amygdalina respectively from 5 th...
Dorstenia psilurus is a widely used plant spice in traditional African medicine to treat pain‐related conditions. However, the anti‐inflammatory mechanisms underlying this activity and main active ingredients of D. have not yet been fully characterized. This study aimed isolate identify constituents extract investigate murine macrophages. Chromatographic techniques spectroscopic data were for compound isolation structure elucidation. The Griess reagent method ferrous oxidation‐xylenol orange...
Investigating the impacts of plant-based substances on regulation pro-inflammatory M1 and anti-inflammatory M2 cytokines could have significant implications for immune-related health conditions. Seven Persicaria plant species from sub-Saharan Africa were specifically selected analysis, based their traditional use in treating inflammation.
Plant extracts are used to treat illnesses, promote health, and maintain general well-being in traditional medicine. Grewia mollis Juss (Malvaceae) is one of the medicinal herbs that traditionally chronic diseases related pain because currently anti-inflammatory drugs may cause severe side effects, naturally occurring compounds with reduced cytotoxicity could be explored for therapeutic goals.Dried leaf G. was extracted aqueous organic solvents partitioned based on polarity using...
To compare health-related quality of life (HRQoL) among patients with diabetes mellitus (DM) and diabetic neuropathy (DN) (D+N) DM without DN (D-DN) healthy participants. evaluate factors associated poor HRQoL in DN.This study included 306 participants residing Bisha, Saudi Arabia. Patients were screened for using the Michigan Neuropathy Screening Instrument. severity, disability determined Severity Scale (NSS), Disability Score (NDS), Norfolk Quality Life-Diabetic (QOL-DN) tool,...
The present work was carried out to investigate the possible effects of ethyl acetate seed fraction Nigella sativa on gastric ulcers and basal secretions using Non-Steroidal Anti-inflammatory Drug-induced (NSAID) model. Phytochemical screening according Trease Evans, 2002 acute toxicity tests Lorke’s Method, 1983 were conducted. For mucosal integrity study, ulcer preventive indices analysed, while volume juice, titratable acidity, acid output pepsin concentration assessed for secretion...
In order to integrate genomics in breeding and development of drought tolerant groundnut genotypes, identification genomic regions/genetic markers for surrogate traits is essential. We used SNP a genetic analysis the ICRISAT minicore collection genome wide marker-trait association some physiological determine magnitude linkage disequilibrium (LD) present resources. The LD showed that about 36% loci pairs were significant (P < 0.05 r2 > 0.2) 3.14% complete LD. There was rapid...