A5048912643- Nerve injury and regeneration
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Axon Guidance and Neuronal Signaling
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Vitamin D Research Studies
- Lipid Membrane Structure and Behavior
- Phytochemicals and Antioxidant Activities
- Skin Protection and Aging
- Acne and Rosacea Treatments and Effects
- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hops Chemistry and Applications
- Cancer-related molecular mechanisms research
- Phytochemistry and Bioactive Compounds
- Retinoids in leukemia and cellular processes
- Graphene and Nanomaterials Applications
- Morinda citrifolia extract uses
- Toxin Mechanisms and Immunotoxins
- Garlic and Onion Studies
- Fungal Plant Pathogen Control
- Heat shock proteins research
- Retinal Diseases and Treatments
Shaqra University
2021-2025
University of Birmingham
2021-2023
Present study deciphers development of oral polysaccharide-based colon targeted solid self-nanoemulsifying drug delivery system (S-SNEDDS) xanthohumol (XH). Several studies have shown that XH has anti-inflammatory and antioxidant properties, suggesting it could be a good candidate for the treatment colorectal diseases (CRD). Despite its potential, low aqueous solubility. As result, bioavailability is constrained by dissolution rate. The liquid (L)-SNEDDS was constituted using Labrafac PG as...
Alopecia areata (AA), is a common autoimmune nonscarring alopecia. Vitamin D involved in various biological processes such as immune regulation, cellular growth, and specialization, well the maintenance of hair cycle. We aimed to explore impact different Tru9I variant genotypes on serum vitamin levels receptor (VDR) gene expression. Case-control study that included 72 individuals diagnosed with AA, along age sex matched healthy controls individuals. Blood samples were obtained measure level...
Idiopathic pulmonary fibrosis is a fatal lung disorder in which the etiology and pathogenesis are still unobvious. Effective treatments urgently needed considering that transplantation only treatment could improve outcomes. This study aimed to investigate therapeutic significance of dual administration pimitespib, an HSP90 inhibitor, nifuroxazide, STAT3 against bleomycin-induced rats. Our results revealed pimitespib/nifuroxazide inhibited alterations structure function lungs. They...
Ulcerative colitis (UC) is a chronic inflammatory life-threatening and premalignant disorder with no cure that even might end up surgical removal of large section or all the colon. It characterized by relapsing-remitting courses intestinal inflammation mucosal damage in which oxidative stress exaggerated response play significant role. Most current medications to maintain remission are symptomatic have many adverse reactions. Therefore, potential for improved management patients UC continues...
This study aims to describe the therapeutic potential of C. nocturnum leaf extracts against diabetes and neurological disorders via targeting α-amylase acetylcholinesterase (AChE) activities, followed by computational molecular docking studies establish a strong rationale behind AChE inhibitory leaves-derived secondary metabolites. In our study, antioxidant activity sequentially extracted leaves extract was also investigated, in which methanolic fraction exhibited strongest DPPH (IC50 39.12...
Abstract Background Acne vulgaris (AV) is a chronic inflammatory skin condition affecting the pilosebaceous unit, commonly presenting as comedones, papules, pustules, or nodules on face, upper limbs, torso, and back, with comedones formation being primary pathology leading to disfiguring inflammation, hyperpigmentation, scarring, psychological impact. Aim The purpose of this study was investigate significance two genetic variants in promoter region tumor necrosis factor‐alpha (TNF‐α) gene...
The present study is aimed at determining the effect of cigarette smoking (CS) on serum uric acid (UA) levels quantitatively before and after cessation among people with MS (pwMS). Additionally, a possible correlation between UA both disability progression disease severity was also investigated. A retrospective cross-sectional conducted using Nottingham University Hospitals Clinics database. It involves 127 definite recorded when reporting latest status clinical diagnosis. All necessary...
CNS neurons are generally incapable of regenerating their axons after injury due to several intrinsic and extrinsic factors, including the presence axon growth inhibitory molecules. One such potent inhibitor regeneration is Reticulon (RTN) 4 or Nogo-A. Here, we focused on RTN3 as its contribution currently unknown. We found that expression correlated with an regenerative phenotype in dorsal root ganglion (DRGN) columns, a well-characterised model spinal cord injury. Overexpression promoted...
The Background: etiology of numerous medical conditions, such as metabolic irregularities, is interconnected with the insufficiency vitamin D. Furthermore, a theoretical association between resistance to insulin and D has been postulated. This concept substantiated by empirical evidence obtained through various investigations. objective this investigation analyze investigate significance influence expression receptor (VDR) gene in progression individuals T2DM. Methods: study was carried out...
Objectives: To investigate the in vivo anticancer effect of Calotropis procera on breast cancer induced female albino rats with 7,12-dimethyl benz(a) anthracene (DMBA). Materials and study design: Fresh leaves C. were obtained from 20 plant specimens collected various regions Dawadmi governorate, Riyadh province, KSA (latitude 24.75387 longitude 46.773686) August 2022. Three extracts (aqueous, chloroform, ethanolic extracts). investigated for their activity that classified into five equal...
Background: Doxorubicin (DOX), an anthracycline antibiotic, is a powerful chemotherapeutic agent effective against multiple types of cancer, particularly lung, breast, bladder and hematologic neoplasia (lymphomas leukemia). However, its therapeutic usage restricted by known cardiotoxicity, which associated with the production oxidative stress. Enhancing antioxidant capacity represents promising approach to mitigate DOX-induced cardiotoxicity. Hesperidin (HES), citrus bioflavonoid, possesses...
Abstract CNS neurons are generally incapable of regenerating their axons after injury due to several intrinsic and extrinsic factors, including the presence axon growth inhibitory molecules. One such potent inhibitor regeneration is Reticulon (RTN) 4 or Nogo-66. Here, we focused on RTN3 as its contribution in currently unknown. We found that expression correlated with an regenerative phenotype dorsal root ganglion (DRGN) columns, a model spinal cord injury. Overexpression promoted...
One of the most common forms mammalian central nervous system (CNS) injuries is spinal cord injury (SCI), and any lesion to CNS can result in a lifelong functional impairment since axons cannot regenerate. The relative axon regenerating genes following SCI were examined using regenerative SN, pSN + DC, non-regenerating DC models. By qRT-PCR, we discovered that fibroblast growth factor receptor-5 (FGFR5) was 4.2-fold more highly expressed non-regeneration lesions compared intact control...