Abstract Background Alopecia areata (AA) is an autoimmune condition characterized by sudden and unpredictable hair loss, with a lifetime incidence of 2%. AA can be divided into three categories: patchy alopecia, alopecia totalis, universalis. It affect person's psychological health overall quality life. Elevated C‐reactive protein (CRP) levels in the liver may indicate inflammatory response diseases. Vitamin D, essential for immune system control skin health, related to AA. Hair follicles...

Abstract Background MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression in diverse biological processes. They hold promise as therapeutic candidates for targeting human disease pathways, although our understanding of their regulatory mechanism remains incomplete. Alopecia areata (AA) is a prevalent inflammatory ailment distinguished by the infiltration T cells anagen‐stage hair follicles. The scarcity effective remedies AA may stem from limited regarding its precise...

ABSTRACT Aim This study aims to provide a comprehensive analysis of keratinocytes, the predominant cell type in epidermis, by examining their structural, functional, and regulatory roles skin biology. The explores intricate processes keratinocyte differentiation, proliferation, immune interactions, emphasizing essential contributions homeostasis, wound healing, barrier integrity. Additionally, it investigates involvement keratinocytes dermatological disorders such as psoriasis, atopic...

Depigmentation of specific areas the skin is a persistent and long-lasting dermatologic disorder known as vitiligo, stemming from impairment disruption melanocytes both structurally functionally, leading to loss pigmentation in those regions.

Acne is a frequently diagnosed skin condition that causes pilosebaceous apparatus clogs and/or inflammatory responses in the majority of teenagers. It multifactorial disease can develop due to various factors. We aimed evaluate lipid profiles and hormonal levels patients with acne correlate them severity. also aim explore alteration their effect on occurrence acne.

Abstract Background Acne vulgaris (AV) is a chronic, multifactorial inflammatory disease of the pilosebaceous unit brought on by hormonal imbalance, excessive sebum production, follicular hyperkeratinization, inflammation and Cutibacterium acne . patients are characterized alteration lipid profile. Apolipoprotein B gene (ApoB) plays an essential role in lipoprotein biosynthesis multiple single‐nucleotide polymorphisms (SNPs) ApoB associated with dyslipidemia. Aim The aim this study was to...

Macrophage scavenger receptor 1 gene (MSR1), is responsible for producing macrophage receptors. MSR1 primarily located on the surfaces of various types and known to exert a range effects human body. These include influencing innate adaptive immunological reactions, as well contributing development conditions such atherosclerosis, dyslipidemia, liver lung disease, cancer. The unregulated assimilation lipoproteins by leads creation macrophages rich in cholesterol that manifest foam-like cells,...

Abstract Background MicroRNAs (miRNAs) are small RNA molecules that play a regulatory role in various biological processes by acting as intracellular mediators. They hold great potential therapeutic agents for targeting human disease pathways; however, there is still much to be uncovered about their mechanism of gene regulation. Alopecia areata (AA) commonly occurring inflammatory condition characterized the infiltration T cells specifically target anagen‐stage hair follicle. The limited...

Background and Aim: Psoriasis is a chronic, relapsing inflammatory multisystemic disease with both genetic predisposition autoimmune pathogenic traits. Several types of vitamin D receptor (VDR) polymorphisms have been investigated as predisposing factor for psoriasis susceptibility controversial results. However, the exact pathophysiological effect VDR gene on remains poorly understood. We aimed to determine whether polymorphisms, specifically rs7975232 (ApaI), afford in given community...

Many clinical features of psoriasis include a rash with itchy, scaly patches, most frequently on the knees, elbows, trunk, and scalp. By studying genes involved receptivity, pathologic pathways become clearer more understood.To predict participation rs1544410 in serum vitamin D levels (SDL) psoriasis, susceptibility, severity.One hundred five patients were categorized by body surface area as mild, moderate, severe. SDL genetic analysis performed using polymerase chain reaction standard...

Insulin resistance (IR) is a condition where cells become resistant to insulin, causing impaired glucose uptake and increased blood levels. Interleukin-12 (IL-12), cytokine, regulates the immune system. High levels of IL-12 can lead chronic inflammation, exacerbate contribute type 2 diabetes. Also, link IR acne vulgaris (AV), as it reduces tissue sensitivity insulin sebum production, which development.

Psoriasis is a chronic, non-contagious autoimmune condition marked by dry, itchy,erythematous and scaly plaques. From modest, localized plaques to total body coverage, the severity of psoriasis varies. Plaque, guttate, inverted, pustular, erythrodermic are five primary kinds. About 90% cases plaque psoriasis, commonly known as vulgaris. Study aims determine impact an rs2228570 (FokI) variant rs11568820 (CDX2) on serum vitamin D levels (SVD) in patients with correlation between two variants...

Abstract Background Acne vulgaris (AV) is a chronic inflammatory skin condition affecting the pilosebaceous unit, commonly presenting as comedones, papules, pustules, or nodules on face, upper limbs, torso, and back, with comedones formation being primary pathology leading to disfiguring inflammation, hyperpigmentation, scarring, psychological impact. Aim The purpose of this study was investigate significance two genetic variants in promoter region tumor necrosis factor‐alpha (TNF‐α) gene...

Teledermatology is a branch of dermatology that transmits medical data over several miles using telecommunications technologies. It involves the diagnosis skin lesions digital photographs and related patient data, it can be especially helpful for patients in remote areas who might not have convenient access to dermatologists. Cutaneous larva migrans (CLM) zoonotic parasitic disease found tropical subtropical are sunny hot; however, cases allocated resources been disclosed Saudi Arabia. There...