A5048812965- Diet, Metabolism, and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioactive Compounds and Antitumor Agents
- Nigella sativa pharmacological applications
- Diet and metabolism studies
- Mesenchymal stem cell research
- Biochemical effects in animals
- Liver Disease Diagnosis and Treatment
- FOXO transcription factor regulation
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Phytochemistry and biological activity of medicinal plants
- Electrospun Nanofibers in Biomedical Applications
- Tea Polyphenols and Effects
- Saffron Plant Research Studies
- Nanoplatforms for cancer theranostics
- Pregnancy and preeclampsia studies
- Alcoholism and Thiamine Deficiency
- Heavy Metal Exposure and Toxicity
- Hemoglobinopathies and Related Disorders
- Sirtuins and Resveratrol in Medicine
- Natural Antidiabetic Agents Studies
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
Qassim University
2017-2025
Mansoura University
2017-2024
Insulin resistance and diabetes are associated with non-alcoholic fatty liver disease (NAFLD) steatohepatitis (NASH) conditions, which distinguished by metabolic dysfunction, oxidative stress inflammation. Sirtuin 1 (SIRT1), a NAD
Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. It was suggested that albendazole (ABZ) powerful inhibitor several types. However, the bioavailability ABZ very poor. Additionally, mechanisms underlying antitumor effects may go beyond its tubulin-inhibiting activity. Therefore, we aimed to examine suspension (i.p. and p.o.) ABZ-loaded cubosomes (LC) on diethylnitrosamine-induced HCC in mice. nanoparticles exhibited mean particle size 48.17 ± 0.65 nm...
Ischemic strokes originate whenever the circulation to brain is interrupted, either temporarily or permanently, resulting in a lack of oxygen and other nutrients. This deprivation primarily impacts cerebral cortex striatum, neurodegeneration. Several experimental stroke models have demonstrated that potent antioxidant quercetin offers protection against stroke-related damage. Multiple pathways been associated with quercetin's ability safeguard from ischemic injury. study examines whether...
The aim of the present study was to assess short-term effects Thymoquinone (TQ) on oxidative stress, glycaemic control, and renal functions in diabetic rats. DM induced groups II III with a single dose streptozotocin (STZ), while group I received no medication (control). rats were then given distilled water, TQ at 50 mg/kg body weight/day for 4 weeks. Lipid peroxidase, nitric oxide (NO), total antioxidant capacity (TAC), glycated haemoglobin (HbA1c), lipid profiles, function assessed....
The clinical application of cyclosporine A (CsA) as an immunosuppressive agent is limited by its organ toxicity. We aimed to evaluate the effectiveness α-lipoic acid against CsA-induced hepatotoxicity and delineate underlying molecular mechanisms. Male Wistar rats (n = 24, 8 per each group) received vehicle, CsA (25 mg/kg) and/or ALA (100 mg/kg, p.o.) for 3 weeks. Biochemical markers liver function (serum ALT, AST, ALP < GGT), oxidative stress (MDA, TAC, SOD, GSH, Nrf2/HO-1), inflammation...
Type 2 diabetes is a chronic condition that requires pharmacotherapy interventions. Metformin and gliclazide are widely used drugs in monotherapy. However, their complementary action made utilization of the combination these an appealing approach.The study compared major therapeutic potentials combined metformin/gliclazide treatment over metformin monotherapy based on following parameters: oxidative stress, lipid profile, hepatorenal functions.This comparative was conducted from March 2015...
Trimester specific reference ranges of hematological indices were described in several populations; however, comparable reports among Sudanese women with normal pregnancy are lacking. To evaluate trimester pattern change and profile pregnancy, we followed 143 singleton gestation since early until the third Saad Abu-Alela Hospital, Khartoum, Sudan, during period January-December 2015. Obstetrics medical history was gathered using questionnaire investigated hemo-analyser. The first, second...
Clobenpropit (CLO), an antagonist on histamine H3 receptors (HH3R), has been shown to protect NMDA-induced neuronal necrosis in cortical cell culture from rats. In this work, we explored its potential lipopolysaccharide (LPS)-induced memory deficits, neuroinflammation, and mitochondrial dysfunction mice. CLO (1 3 mg/kg, p.o.) was treated continually for 30 days, neurotoxicity induced by four doses of LPS (250 µg/kg, i.p.). The radial arm maze (RAM) used access behaviors. After the REM test,...
Background: Gentamicin (GM) is an antibiotic that widely used to treat many Gram-negative bacteria, such as those involved in urinary tract infections. However, being nephrotoxic, GM dose adjustment and reno-protective elements must be concurrently administered with minimize kidney damage. Oxidative stress plays a pivotal role the pathogenesis of GM-induced nephrotoxicity. Thymoquinone (TQ) promising therapeutic substance, extensively studied diseases, diabetes mellitus, cancer,...
Background: Oxidative stress, lipid profile and renal functions are well-known conventional risk factors for diabetes mellitus (DM). Metformin gliclazide popularly used monotherapy drugs the treatment of DM. Aims: This study aims to assess short-term single dual therapy glipizide/metformin on oxidative glycemic control, serum profiles function in diabetic rats. Methods: DM was induced rats with streptozotocin (STZ), then five different treatments were applied, including group I (untreated...
Background: Previous reports claimed that lead enhances oxidative stress and induces renal dysfunction. Antioxidant free radicals scavenger properties of green tea extract (GTE) can play a protective role against harmful effects on the kidneys. Objectives: (1) to assess function stress, (2) investigate GTE lead-induced Methods: 60 male Sprague-Dawley rats were divided into four equal groups (N= 15 rat for each); control group (received distilled water), GTE–group as 1.5% w/v), Pb–group...
Aims: In this study, the authors aimed to examine functional activities (adhesion, proliferation, and migration) of hMSCs under effects various concentrations inflammatory mediators, such as TNF α or IFNg. Methods: HMSCs were exposed mediators IFNg, IFNg on properties determined using multiple assays migration). HMSC expression genes (cytokine, chemokine, adhesion molecule genes) was analyzed real-time polymerase chain reaction (RT–PCR). Results: promoted their proliferation migration...
BACKGROUND: Hydroxychloroquine (HCQ) is used in the treatment of malaria and rheumatoid arthritis for a long time. Its effects on inflammation immune modulation were noted.
 AIM: This study aims to investigate HCQ fructose-induced metabolic syndrome explore its possible mechanisms.
 METHODS AND MATERIALS: Sixty male Sprague-Dawley rats divided into Group I (negative control), II fed high-fructose diet, III high fructose subdivided III-a (HCQ 50 mg/kg), III-b 100 III-c 200 III-d...