The aim of the present study was to assess short-term effects Thymoquinone (TQ) on oxidative stress, glycaemic control, and renal functions in diabetic rats. DM induced groups II III with a single dose streptozotocin (STZ), while group I received no medication (control). rats were then given distilled water, TQ at 50 mg/kg body weight/day for 4 weeks. Lipid peroxidase, nitric oxide (NO), total antioxidant capacity (TAC), glycated haemoglobin (HbA1c), lipid profiles, function assessed....

Previous heart rate variability (HRV) studies in asthmatic subjects (AS) demonstrate predominance of parasympathetic drive concomitant with low HRV, which is against the general belief that enhanced modulation improves HRV. The aim this study was to compare patterns HRV and cardiac autonomic modulations AS healthy control (HS).Eighty forty HS were enrolled study. Asthma test spirometry used discriminate uncontrolled (UA) from controlled (CA) patients. Natural logarithmic (Ln) scale total...

Background: Ischemic stroke usually initiates inflammation and oxidative/nitrosative stress leading to neuronal death. Aim:To investigate the existence of oxidative/nitrosativestress in rats subjected focal cerebral ischemia/reperfusion its effects on consequent neurological deficits. Material Method:Experimental procedures were performed 30 adult males Wister rats.In test group, transient ischemia was induced 15 by occlusion left common carotid artery (CCA) for minutes followed reperfusion...

Background Although the exact pathophysiology of preeclampsia is not well understood, autonomic nervous system imbalance suggested as one main factors. Aims To investigate heart rate variability (HRV) and modulations in Sudanese pregnant women with preeclampsia. Subjects Methods A case-control study (60 each arm) was conducted at Omdurman Maternity Hospital—Sudan, during period from June to August, 2014. Cases were presented healthy controls. Studied groups matched for important determinants...

Background: Although enhanced cholinergic activity of asthmatics has been established early on, little heart rate variability (HRV) studies were done on asthma patients. Previous HRV based 24-hour recordings and therefore have not considered the extremely labile bronchial asthma. Objective: To evaluate pattern autonomic modulations in asthmatic patients short-term studies. Materials Methods: The study involved 100 with an age range 20-40 years. Asthma was evaluated over last month prior to...

Previous reports assessing the neuroprotective role of nonselective Nitric Oxide synthase (NOS) inhibitor N-nitro-L-arginine-methylester (L-NAME) following cerebral ischemia/reperfusion are contradictory. The aim this work was to examine potential benefits L-NAME on rats subjected transient focal ischemia/reperfusion.The study involved 30 adult male Wistar divided into three groups 10 in each: First group sham-operated and served as a control, (I/R) infused with 0.9% normal saline...

Previous studies reported increased risk of cardiac events in subjects with fasting blood glucose (FBG) levels lower than the diagnostic threshold diabetes mellitus. However, whether those upper normal FBG is secondary to shift their sympathovagal balance towards sympathetic predominance unknown.To assess association between and autonomic modulation (CAM) euglycaemic healthy based on heart rate variability (HRV) derived indices.The study enrolled 42 young adults. Following sociodemographic...

Type 2 diabetes is a chronic condition that requires pharmacotherapy interventions. Metformin and gliclazide are widely used drugs in monotherapy. However, their complementary action made utilization of the combination these an appealing approach.The study compared major therapeutic potentials combined metformin/gliclazide treatment over metformin monotherapy based on following parameters: oxidative stress, lipid profile, hepatorenal functions.This comparative was conducted from March 2015...

To assess the association between obesity and iron deficiency (ID).Pregnant women were recruited from Saad Abualila Hospital, Khartoum, Sudan, during January-April 2015. Medical history (age, parity, gestational age) was gathered using questionnaire. Weight height measured, body mass index (BMI) calculated. Women sub-grouped based on BMI into underweight (< 18.5 kg/m^2), normal weight (18.5-24.9 overweight (25-29.9 kg/m^2) obese (≥ 30 kg/m^2). Serum ferritin red blood indices measured in all...

Preeclampsia is an important cause of maternal and prenatal morbidity mortality in the developing countries. Changes thyroid function/antibodies profiles preeclamptic women are controversial were never investigated before Sudan. A case-control study was conducted at Medani Hospital, Sudan, to investigate preeclampsia. The sociodemographic, medical history gathered using questionnaires. Thyroid hormones [thyroid-stimulating hormone (TSH), free tri-iodothyronine (T3), thyroxine (T4)]...

Background: Previous data on the possible effects of age and gender serum lipids profile elderly people showed considerable debates. Aim: to evaluate measurements in over 55 years-old Sudanese individuals. Materials methods: The study involved sixty-four males forty agematched females. studied subjects were grouped according their ages into those < 60 years, 60-69 years ≥ 70 years. Following at least 12 hours fasting, triglycerides (TG), total cholesterol (TC), high density lipoprotein...

Trimester specific reference ranges of hematological indices were described in several populations; however, comparable reports among Sudanese women with normal pregnancy are lacking. To evaluate trimester pattern change and profile pregnancy, we followed 143 singleton gestation since early until the third Saad Abu-Alela Hospital, Khartoum, Sudan, during period January-December 2015. Obstetrics medical history was gathered using questionnaire investigated hemo-analyser. The first, second...

Labor necessitates continuous adjustments of cardiac autonomic reflexes by alternate activation the sympathetic and parasympathetic nervous systems. The division system that predominates during first stage labor is unclear needs to be further investigated. study aimed compare heart rate variability (HRV) in pregnant women third trimester with those labor. We conducted a case–control at Saad Abul Ela Maternity Hospital, Khartoum, Sudan. Forty-five singleton, live neonates 45 (but not labor)...

Objective To evaluate thyroid function and hormonal profile in women with polycystic ovary syndrome (PCOS). Methods A case-control study was conducted at Saad Abualila Center, Khartoum, Sudan. The cases were confirmed PCOS based on Rotterdam criteria. controls infertile no evidence of PCOS. socio-demographic characteristics medical history gathered using a questionnaire. Thyroid hormones (thyroid-stimulating hormone, free tri-iodothyronine, thyroxine), anti-thyroid peroxidase,...

Trimester-specific reference ranges for T3, T4, and TSH need to be established in different communities. Neither Sudan nor other African countries have trimester-specific TSH, free T3 (FT3), T4 (FT4) healthy pregnant women. This study aimed establish FT3, FT4 Sudanese women.We performed a longitudinal study, which included 63 women with singleton pregnancies who were followed since early pregnancy until the third trimester. The was Saad Abu-Alela Hospital, Khartoum, Sudan, during January...

Although ventricular late potential (VLP) was extensively studied in risk stratification of myocardial infarction (MI) patients, comparable researches evaluating presence VLP MI-free coronary artery disease (CAD) and cardiac syndrome X (CSX) subjects are scarce. This study aimed to compare between CSX CAD patients. Signal average ECG (SAECG) performed 49 patients with a history typical pain before undergoing diagnostic angiography (DCA) Al-Shaab center, Khartoum, Sudan. QRS duration,...

Background: Oxidative stress, lipid profile and renal functions are well-known conventional risk factors for diabetes mellitus (DM). Metformin gliclazide popularly used monotherapy drugs the treatment of DM. Aims: This study aims to assess short-term single dual therapy glipizide/metformin on oxidative glycemic control, serum profiles function in diabetic rats. Methods: DM was induced rats with streptozotocin (STZ), then five different treatments were applied, including group I (untreated...

We investigated zinc and copper levels in angiographically defined obstructive coronary artery disease (CAD) patients undergoing elective angiography El-Shaab Hospital, Sudan. performed a cross-sectional study. One hundred forty-two were enrolled. Sociodemographic medical characteristics collected using questionnaire. Glucose, lipid, zinc, measured. Out of 142 patients, 102 (71.8%) had CAD 40 (28.2%) patent arteries. There no significant differences median (interquartile range) [118.5...

Context: Cigarette smoking is a risk factor for wide range of diseases; however, still there are no laboratory screening tests early detection the possible biochemical derangements induced by smoking. Aim: to evaluate serum cholesterol, liver enzymes, uric acid and hemoglobin concentrations in smokers regardless their present complain. Materials Methods: study involved control group apparently healthy non-smokers (N = 105) matched age with test 105). The both groups was 25-63 years. Random...

Background:The pattern of change in FEF50%, FEF25%-75% and FEF50%/FEF25%-75% ratio depends on mechanics forceful expiration, provided that non-homogenous lung emptying is faithfully recorded the expiratory flow-volume loops.Objective: To assess potential clinical value as an indicator bronchial asthma (BA) control. Methodology:The study involved 75 patients with BA matched for age gender 45 non-asthmatic subjects.Based control test (ACT) spirometry, asthmatic were subdivided into controlled...

Abstract Background There are few researches on hematological parameters (hemoglobin, red cell distribution width [RDW], white blood cells [WBCs], mean platelets volume [MPV], and heart rate variability [HRV]). no published data this concept (HRV parameters) during pregnancy. Methods A cross‐sectional study was conducted at Saad Abul Ela hospital in Khartoum, Sudan the period of July to August 2018. Pregnant women with singleton, a live baby, were enrolled study. Clinical history examination...

There were no studies on the anti-inflammatory activity of Euphorbia aegyptiaca, though it is commonly used by Sudanese herbalists in treatment rheumatoid arthritis.To determine phytochemical constituents aegyptiacaTo investigate aegyptiaca rats.Plant material was extracted ethanol and screening done according to standard methods. The thickness Albino rats' paws measured before injection 0.1 ml 1% formalin sub planter region then, 1, 2, 3, 4 24 hours after oral dose ethanolic extract at a...