A5088507623- Liver Disease Diagnosis and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Hepatitis B Virus Studies
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Paraoxonase enzyme and polymorphisms
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Epilepsy research and treatment
- Diet, Metabolism, and Disease
- Ovarian cancer diagnosis and treatment
- Streptococcal Infections and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Cholinesterase and Neurodegenerative Diseases
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Bacterial Infections and Vaccines
Cairo University
2008-2024
Ahram Canadian University
2019-2024
Mansoura University
1975-2024
King Saud University
1988-2017
Children Cancer Hospital
2011
October University of Modern Sciences and Arts
2011
Cancer Institute (WIA)
2007
Memorial Sloan Kettering Cancer Center
1994
Mansoura University Hospital
1992
Population Council
1990
Hepatocellular carcinoma accounts for about 80-90% of all liver cancer and is the fourth most common cause mortality. Although there are many strategies treatment cancer, chemoprevention seems to be best strategy lowering incidence this disease. Therefore, study has been initiated investigate whether thymoquinone (TQ), Nigella sativa derived-compound with strong antioxidant properties, supplementation could prevent initiation hepatocarcinogenesis-induced by diethylnitrosamine (DENA), a...
Cisplatin (CP) is commonly used in the treatment of different types cancer but nephrotoxicity has been a major limiting factor. Therefore, present study aimed to possible protective effect rutin against induced by cisplatin rats. Forty male Wistar albino rats were randomly divided into 4 groups. Rats group 1 control intraperitoneal (i.p.) received 2.5 ml/kg, 2 CP single dose 5 mg/kg i.p. 3 orally 30 (CP plus rutin) and as 3. Kidneys harvested for histopathology gene expression c-Jun...
The use of natural compounds is promising in approaches to prevent and treat cancer. long-term application most currently employed chemotherapy techniques has toxic side effects. Eugenol, a phenolic phytochemical extracted from certain essential oils, an anti-cancer effect. modulation autophagy can promote either the survival or apoptosis cancer cells. Triple-negative (MDA-MB-231) HER2 positive (SK-BR-3) breast cell lines were treated with different doses eugenol. Apoptosis was detected by...
Abstract This study examined the possible protective effects of thymoquinone (TQ), main constituent volatile oil black seed ( Nigella sativa ), against cyclophosphamide (CP)‐induced cardiotoxicity. Adult male Wistar albino rats were divided into four treatment groups. Rats in first group served as control. second received TQ (50 mg/L drinking water) for 12 days. Animals third injected with a single dose CP (200 mg/kg, IP) at day 5. fourth 5 days before and continued thereafter throughout...
Abstract Background High-cholesterol diet (HCD) increases the oxidative stress in different tissues leading to many diseases. Rutin (RT) is a natural flavonoid (vitamin p), which possesses an antioxidant activity with protective potential. The present study aimed examine potential effects of rutin on hypercholesterolemia-induced hepatotoxicity rat. Methods Male Wistar rats were divided into four groups: GI) control (Rat chow), GII) (0.2% rat GIII) HCD (1% cholesterol and 0.5% cholic acid...
Aim and background: MicroRNAs (miRNAs) are a class of naturally occurring small noncoding RNAs that regulate gene expression, cell growth, differentiation apoptosis by targeting mRNAs for translational repression or cleavage. The present study was conducted to miRNAs in Egyptian breast cancer (BC) their relation metastasis, tumor invasion addition association with the ER PR statuses. Methods: Real Time RT-PCR performed identify miRNA expression level eight metastatic-related genes 40 samples...
Carbon tetrachloride (CCl4) induces hepatotoxicity in animal models, including the increased blood flow and cytokine accumulation that are characteristic of tissue inflammation. The present study investigates hepato-protective effect rutin on CCl4-induced rats.Forty male Wistar rats were divided into four groups. Group I (control group) received 1 mL/kg dimethyl sulfoxide intragastrically 3 olive oil intraperitoneally twice a week for 4 weeks. II 70 mg/kg intragastrically. Groups III IV CCl4...
Cisplatin is widely used chemotherapeutic agent for cancer treatment with limited uses due to its neurotoxic side effect. The aim of this study was determine the potential preventive effects rutin on brain cisplatin- rat model.Forty rats were divided into four groups. Group-1 (control group) intra-peritoneal (IP) injected 2.5 ml/kg saline. Group-2 (rutin orally administrated 30 mg/kg dissolved in water 14 days. Group-3 (cisplatin IP received 5 cisplatin single dose. Group-4 and days a dose...
Eugenol is a natural phenolic compound and possesses anticancer antibacterial activities. Breast cancer major global health problem, most of the chemotherapeutic agents are highly toxic with long-term side effects. Therefore, this study aimed to explore possibility using eugenol as an anti-metastatic anti-proliferative agent against MDA-MB-231 SK-BR-3 breast cells.Breast cell lines were treated proliferation was measured real-time electronic sensing system. Annexin V analysis flow cytometry...
Here, we examined the protective effect of ferulic acid (FA) on cadmium chloride (CdCl2)-mediated reproductive toxicity in male rats. Animals were divided into four groups: control, FA (20 mg/kg), CdCl2 (6.5 and + CdCl2. treatment evoked a significant increase testis concentration addition to obvious testosterone, luteinizing hormone, follicle-stimulating hormone levels. Moreover, CdCl2-induced oxidative damage through exhausting cellular defenses (superoxide dismutase, catalase, glutathione...
Pulmonary fibrosis (PF) is a life-threatening disorder with very poor prognosis. Because of the complexity PF pathological mechanisms, filling such an unmet medical need challenging. A number pulmonary diseases have been linked to activation NF-κB and NLRP3 inflammasome. Coomassie brilliant blue G-250 (CBBG) proved be safe highly selective P2×7R antagonist promising consequent inactivation This first report investigate effect CBBG on bleomycin-induced lung in rats. Our findings revealed that...
Doxorubicin is an antibiotic broadly used in treatment of different types solid tumors. The present study investigates whether L-carnitine, antioxidant agent, can reduce the hepatic damage induced by doxorubicin. Male Wistar albino rats were divided into six groups: group 1 intraperitoneal injected with normal saline for 10 consecutive days; 2, 3 and 4 every other day doxorubicin (3 mg/kg, i.p.), to obtain treatments cumulative doses 6, 12, 18 mg/kg. fifth was L-carnitine (200 i.p.) days...
The prevalence of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) has increased recently. aim this study was to further characterise and assess the occurrence ESBL-EC in Riyadh, use pulsed field gel electrophoresis (PFGE) typing investigate epidemiology determine ST131 ESBL-EC. A total 152 E. isolates were collected at a tertiary hospital Riyadh from September 2010 June 2011. Genotypic phenotypic methods used ESBLs. PFGE genetic relatedness. Detection CTX-M-like ESBLs...
Liver diseases are major global health problems. Ginseng extract has antioxidant, immune-modulatory and anti-inflammatory activities. This study investigated the effect of ginseng on carbon tetrachloride (CCl4)-induced liver fibrosis in rats.Male Wistar rats were divided into four groups: control group, CCl4 group + group. injury was induced by intraperitoneal (I.P) injection 3 ml/kg (30% olive oil) weekly for 8 weeks. The I.P injected with oil. expression genes encoding transforming growth...
The role of Epstein-Barr virus (EBV) in breast carcinogenesis is still controversial. Unraveling this relationship potentially important for better understanding cancer etiology, early detection and possibly prevention cancer. aim the current study to unravel association between EBV primary invasive (PIBC) two different Arab populations (Egyptian Iraqi women).The was done on paraffin-embedded tissues 40 Egyptian 50 patients with PIBC addition 20 normal as controls each group. Both neoplastic...
Human papillomavirus (HPV) is associated with different malignancies but its role in the pathogenesis of ovarian cancer controversial. This study investigated prevalence, genotyping and physical state HPV Saudi patients.Hundred formalin fixed paraffin embedded (FFPE) carcinoma tissues their normal adjacent (NAT) were included study. was detected by nested polymerase chain reaction (PCR) using degenerated HPVL1 consensus primer pairs MY09/MY11 GP5+/GP6 + to amplify a broad spectrum genotypes...
Objectives . The purpose of the study is to evaluate hepatoprotective effect rutin in carbon tetrachloride- (CCl 4 -) induced liver injuries rat model. Methods Forty male Wistar albino rats were divided into four groups. Group I was control group and received dimethyl sulphoxide (DMSO) olive oil. II rutin. Groups III treated with CCl IV administered after 48 h treatment. Liver enzymes level, lipid profile, peroxidation, hydrogen peroxide measured. genes expression levels monitored by real...
There are eight genotypes of hepatitis B virus (A-H) and subgenotypes recognized. Genotyping can be accomplished based on a partial sequence HBV genome such as the pre-S or S gene. Several methods have been developed used for genotyping. This study was undertaken to determine in Egyptian pediatric cancer patients with acute chronic liver disease. were determined 22 who had forms disease (AH) 48 active (CAH). A type-specific primer nested-PCR method employed showed that infections attributed...
Occult HBV infection accelerates the progression of liver fibrosis, cirrhosis, and finally leading to hepatocellular carcinoma (HCC). This study analyzed occult HBV-genotypes in HCC patients.To achieve our objective, matched serum tissue samples were collected from 40 patients. Three sets primers used for HBV-DNA detection by nested-PCR, which cover HBV-genome; Core, Surface X genes. Genotyping system based on PCR using type-specific was applied positive samples.Intrahepatic detected 62.5%,...