Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in which phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (PKB or Akt) pathway deregulated response to phosphatase and tensin homolog (PTEN) overexpression. Lactoferrin (LF), a multifunctional iron-binding glycoprotein, involved AD pathology; however, direct evidence its impact upon remains unclear. To elucidate LF's role AD, possible protective mechanism post-LF administration for 3 months...

The current study aims to investigate the antidiabetic efficacy of camel milk-derived lactoferrin and potential involvement PPAR-γ SIRT-1 via TLR-4/NFκB signaling pathway in obese diabetic pediatric population. Sixty young patients with type 2 diabetes were selected from Pediatric Endocrine Metabolic Unit, Cairo University randomly divided among two age sex-matched groups so as receive either standard therapy without one arm or be treated oral capsules (250 mg/day, p.o) for 3 months other...

The role of Epstein-Barr virus (EBV) in breast carcinogenesis is still controversial. Unraveling this relationship potentially important for better understanding cancer etiology, early detection and possibly prevention cancer. aim the current study to unravel association between EBV primary invasive (PIBC) two different Arab populations (Egyptian Iraqi women).The was done on paraffin-embedded tissues 40 Egyptian 50 patients with PIBC addition 20 normal as controls each group. Both neoplastic...

Abstract Background Coinfections and reactivation of persistent or latent viral infections such as herpesviruses (HHV) and/or measles virus (MeV) have been reported among COVID-19 patients. However, there is limited information regarding cancer patients who experienced severe acute respiratory syndrome corona virus-2 (SARS-CoV-2). The primary purpose this study was to investigate the interplay between SARS-CoV-2, HHV MeV in patients, aiming provide insights into pathophysiology these enhance...

Liver disease progression from chronic hepatitis C virus (HCV) infection to hepatocellular carcinoma (HCC) is associated with an imbalance between T-helper 1 and 2 cytokines. Evaluation of cytokines as possible candidate biomarkers for prediction HCC was performed using soluble Fas(sFas), tumor necrosis factor receptor-II (sTNFR-II), interleukin-2 receptor (IL-2R) interleukin-8 (IL-8).The following patients were recruited: 79 HCV infection, 30 HCC, 32 liver elevated enzyme levels (with or...

We studied promoter methylation (PM) of 11 genes in Peripheral Blood Lymphocytes (PBLs) and tissues hepatitis C virus (HCV) associated hepatocellular carcinoma (HCC) chronic (CH) Egyptian patients. The present study included 31 HCC with their ANT, 38 CH 13 normal hepatic tissue (NHT) samples. In all groups, PM APC, FHIT, p15, p73, p14, p16, DAPK1, CDH1, RARβ, RASSF1A, O(6)MGMT was assessed by methylation-specific PCR (MSP). APC O6-MGMT protein expression immunohistochemistry (IHC) the (20...

Deregulation of noncoding RNAs, microRNAs (miRNAs) and long RNA (lncRNA), are implicated in the initiation progression gastric cancer (GC). This study is a pilot case-control carried out on 75 subjects, 40 them were Helicobacter pylori-gastric ulcer patients 35 GC recruited from Gastrointestinal Endoscopy Unit Al-Kasr Al-Aini Hospital, Cairo University Egypt. Real-time PCR was performed to evaluate expression level serum miR-204, miR-182, lncRNA H19 with peptic ulcer-progressed vs...

Chlorinated pesticides (CP) are environmentally persistent pollutants that (prenatally through the placenta and post-natally via breastfeeding) transferred from mother to child. Considering significant bleeding tendency noted in infants of CP-intoxicated mothers Egypt, this study aimed investigate any correlation between levels these xenobiotics mothers' milk tendencies their infants, as well a possible role related immunosuppression phenomenon. This examined 180 newborns presenting with...

Though significant progress has been made towards new diagnostic approaches for early detection of acute kidney injury (AKI) induced by different factors, there is still an urgent demand a more specific and predictive biomarker each type. The aim this study to unravel the potential utility circulating osteoprotegerin (OPG) in septic patients who developed AKI ICU, compared cystatin C (a renal function maker) KIM-1 damage marker). Eighty (male = 43, female 37) with ages ranging from 42 46...

Spontaneous coronary artery dissection (SCAD) is a rare cause of acute syndrome. This case involves multivessel SCAD requiring intervention. The patient 39-year-old woman suffering from non-ST elevation myocardial infarction caused by SCAD. first angiography revealed changes suggestive distal left anterior descending (LAD) spontaneous with partial occlusion and old circumflex obtuse marginal dissections. A repeated angiogram total the LAD. Balloon angioplasty was done to LAD, achieving good...

The association between simian virus (SV40) and malignant pleural mesothelioma (MPM) suggests an etiological role for SV40. However, exact pathogenetic mechanisms possible prognostic value are not clear. purpose of the present paper was to investigate 40 Egyptian MPM patients presence SV40 DNA, altered Rb expression p53 gene status using immunohistochemistry molecular techniques. relation SV40, asbestos exposure, Rb, their contribution overall survival (OS) were also assessed. DNA detected...

Combined pegylated interferon-α and ribavirin therapy has sustained virological response (SVR) rates of 54% to 61%. Pretreatment predictors SVR interferon have not been fully investigated yet. The current study assesses a group chemokines that may predict treatment in Egyptian patients with chronic HCV infection. CXCL5, CXCL9, CXCL11, CXCL12, CXCL 13, 16 E-Cadherin were assayed 57 patients' sera using quantitative ELISA plate method. All studied scheduled for combined alpha (32 received α...

SV40 DNA sequences have been detected in non-Hodgkin's lymphoma patients. A link between and NHL is biologically plausible since causes hematological malignancies laboratory rodents. We investigated 266 Egyptian cases of (158 NHL, 54 HD, 26 ALL, 13 AML, 8 CLL, 7 CML) 34 subjects as a control for detection using nested PCR. were found (53.8%) (29.6%) HD (40.7%) different types leukemia cases. Frequency was higher patients compared with those the other tumors group (p < 0.05). The highest...

Infection with hepatitis C virus (HCV) frequently results in a persistent infection, suggesting that it has evolved efficient mechanism(s) for blocking the host cell's innate antiviral response. The immune response to infection activation or direct induction of interferon regulatory factors (IRFs), which are family proteins involved regulation (IFN) and IFN inducible genes. IRF-3 IRF-7 have been shown play an essential role virus-dependent signaling, whereas IRF-1 is critical proper...

In practice, there is increasing recognition of the importance hypothalamic pituitary adrenal axis in cardiovascular disease progression. The association brain natriuretic peptide with obesity and characteristics metabolic syndrome adults aged patients well established, but that pediatrics needs thorough elucidation.The aim this study was to assess mediators (cortisol aldosterone) plasma NT-pro β-type (NT-proBNP) levels on metabolic, immune-inflammatory endothelial markers young obese...