Clinical use of doxorubicin (DOX) is limited by its cardiotoxic side effects. Recent studies established that metformin (MET), an oral antidiabetic drug, possesses antioxidant activity. However, whether it can protect against DOX-induced energy starvation and mitochondrial damage has not been reported. Our results, in a rat model cardiotoxicity, show DOX treatment significantly increased serum levels LDH CK-MB, indicators cardiac injury, induced expression hypertrophic gene markers. also...

Doxorubicin is an antibiotic broadly used in treatment of different types solid tumors. The present study investigates whether L-carnitine, antioxidant agent, can reduce the hepatic damage induced by doxorubicin. Male Wistar albino rats were divided into six groups: group 1 intraperitoneal injected with normal saline for 10 consecutive days; 2, 3 and 4 every other day doxorubicin (3 mg/kg, i.p.), to obtain treatments cumulative doses 6, 12, 18 mg/kg. fifth was L-carnitine (200 i.p.) days...

Interaction of doxorubicin DOX with iron and the consequent generation reactive oxygen species (ROS) is a major player in DOX-induced cardiomyopathy. Accordingly, this study has been initiated to investigate preventive effect chelator, desferrioxamine (DFX), against acute cardiotoxicity rats. Male Wistar albino rats were divided into four groups injected intraperitoneally (I.P.) normal saline, single dose (15 mg/kg), DFX (250 mg/kg) combined treatment 30 min prior DOX, mg/kg). A...

Hormonal receptor positive (HR+) breast cancer is the most commonly diagnosed molecular subtype of cancer; which showed good response to doxorubicin (DOX)-based chemotherapy. Eugenol (EUG) and astaxanthin (AST) are natural compounds with proved epigenetic immunomodulatory effects in several cell lines. This study has been initiated investigate mechanism (s) whereby EUG AST could enhance DOX cytotoxicity MCF7 cells.Cytotoxic activity alone combined either 1 mM or 40 μM was performed using...

Abstract: The major limiting factor in long‐term administration of doxorubicin is the development cumulative dose‐dependent cardiomyopathy and congestive heart failure. Although several mechanisms have been suggested to explain exact cause doxorubicin‐induced cardiomyopathy, role vascular endothelium‐derived vasoactive mediators pathophysiology this toxic effect still unknown. Accordingly, present study has initiated investigate whether changes plasma level endothelin‐1 nitric oxide along...

This study has been initiated to investigate whether sunitinib (SUN) alters the expression of key genes engaged in mitochondrial transport and oxidation long chain fatty acids (LCFA), if so, these alterations should be viewed as a mechanism SUN-induced cardiotoxicity, explore molecular mechanisms whereby carnitine supplementation could attenuate cardiotoxicity. Adult male Wister albino rats were assigned one four treatment groups: Rats group 1 received no but free access tap water for 28...

This study evaluated the mechanistic sequel of aldehyde dehyrogenase (ALDH2) and Klotho protein in cyclophosphamide (CP)-induced cardiotoxicity rats protective effect astaxanthin (AST) against that sequel. A total 40 male Wistar albino were divided into four groups 10 animals each: Group 1 was injected intraperitoneally (i.p.) with normal saline for successive days. 2 5 days before after a single dose CP (200 mg/kg, i.p.). 3 received AST (50 mg/kg/day, i.p.) 4 as group 3. After last...

Aim The role of surgical castration and rosuvastatin treatment on lipid profile metabolism related markers was evaluated for their prognostic significance in metastatic prostate cancer (mPC) patients. Methods A total 84 newly diagnosed castrated mPC patients treated with were recruited divided into two groups: Group I served as control (statin non-users) while group II Rosuvastatin (20 mg/day) 6 months statin users. Prostate specific antigen (PSA), epidermal growth factor receptor (EGFR),...

Background: Worldwide, breast cancer is a main cause of morbidity and mortality in females. Doxorubicin (DOX) an anthracycline anticancer drug most commonly employed polychemotherapy protocols the treatment solid hematological tumors. Unfortunately, its optimal clinical benefit limited secondary to rapid development DOX resistance therapeutic failure.
 Aim: Therefore, current study has been initiated investigate possible mechanisms whereby calcium channel blocker Verapamil (VER) could...

Abstract Background: Hormonal receptor positive (HR+) breast cancer is the most commonly diagnosed molecular subtype of cancer; which showed good response to doxorubicin (DOX)-based chemotherapy. Eugenol (EUG) and astaxanthin (AST) are natural compounds with proved epigenetic immunomodulatory effects in several cell lines. This study has been initiated improve cytotoxic activity reduce resistance DOX through combination EUG AST MCF7 cells. Methods: Cytotoxic alone combined either 1mM or 40µM...

Abstract Background: Hormonal receptor positive (HR+) breast cancer is the most commonly diagnosed molecular subtype of cancer; which showed good response to doxorubicin (DOX)-based chemotherapy. Eugenol (EUG) and astaxanthin (AST) are natural compounds with proved epigenetic immunomodulatory effects in several cell lines. This study has been initiated improve cytotoxic activity reduce resistance DOX through combination EUG AST MCF7 cells. Methods: Cytotoxic alone combined either 1mM or 40µM...

This study examined the mechanism whereby carnitine supplementation attenuates doxorubicin‐induced hepatotoxicity in rats. Male Wistar albino rats were divided into six groups: Rats group 1 injected I.P. with normal saline and served as control; 2, 3 4 every other day doxorubicin (3 mg/kg, i.p.), to obtain treatments cumulative doses of 6, 12, 18 mg/kg. fifth L‐carnitine (200 i.p.) for 10 consecutive plus a dose (18 mg/kg). Administration resulted significant dose‐dependent increase serum...