Metformin is one of the most commonly prescribed antidiabetic drugs. A recent clinical study has highlighted protective role metformin against cardiac complications in type I diabetes. Curcumin a natural compound with well-known antioxidant and anti-inflammatory properties. The present was designed to investigate possible curcumin potentiating metformin`s putative effects. Rats received single injection 52.5 mg/kg streptozocin diabetic rats were treated (200 mg/kg/day), (100 mg/kg/day) their...

Abstract Background Nanoparticles are small-scale substances (<100 nm) with unique properties. Therefore, nanoparticles pose complex health risk implications. The objective of this study was to detect whether treatment quercetin (Qur) and/or arginine (Arg) ameliorated nephrotoxicity induced by two different doses nano zinc oxide (n-ZnO) particles. Method ZnO were administered orally in (either 600 mg or 1 g/Kg body weight/day for 5 conscutive days) Wister albino rats. In order the...

Although zinc oxide nanoparticles (ZnO-NP) are being used on a wide scale in the world consumer market, their potential hazards humans remain largely unknown. The present study was aimed at investigating oral toxicity of ZnO-NP 2 dose regimen (600 mg/kg and 1 g/kg body weight for 5 consecutive days) rats. In addition, protective role either α-lipoic acid (Lipo) or vitamin E (Vit E) against this cardiotoxic effect ZnO-NPs assessed. Results revealed that, co-administration Lipo (200 mg/Kg...

The aim of this study was to investigate the toxic impacts titanium dioxide nanoparticles (TiO2-NPs) on rat kidneys and possible prophylactic role either quercetin or idebenone. TiO2-NPs were administered orally at 600 mg 1 g/kg body weight for 5 consecutive days evaluate dose-dependent toxicity referred OECD guidelines testing chemicals. results showed that administration low high repeated doses rats significantly increases serum kideney function biomarkers (urea, creatinine uric acid) as...

Objective Schizophrenia is associated with profound cognitive and psychosocial impairments. Glucagon‐like peptide‐1 receptor agonists ( GLP ‐1 RA s) are used for diabetes obesity treatment, animal studies have indicated cognitive‐enhancing effects. In this investigator‐initiated, double‐blind, randomized, placebo‐controlled trial, we tested non‐metabolic effects of exenatide once‐weekly (Bydureon™) in obese, antipsychotic‐treated patients schizohrenia spectrum disorder. Method Before after 3...

Transforming growth factor-β (TGF-β1) enhances the expression of apoptosis induced by certain cytokines and oncogenes. Activation small mother against decapentaplegic (Smads) TGF-β results in fibrotic, apoptotic processes. PI-3/AKT focal adhesion kinase-phosphatidylinositol3-kinase (AKT), mitogen-activated protein kinase (MAPK) signal transducer activator transcription-3 (STAT3) pathways are influence COX-2 VEGF-stimulating pathways. NF-E2-related factor-2 (Nrf2) is an essential...

This study is designed to evaluate the potential impact of N-acetyl cysteine (NAC) and coenzyme Q10 (CoQ10) each alone or in combination against carbon tetrachloride (CCl4)-induced cardiac damage rats. Animals were treated with CCl4 single intraperitoneal dose 1 mL/Kg body weight; CCl4-intoxicated animals pretreated 20 mg/kg/d NAC 200 CoQ10 same previously mentioned doses. Carbon tetrachloride-intoxicated rats showed a significant elevation nitric oxide lipid peroxides downregulation reduced...

Mismatch negativity (MMN) is a measure of pre-attentive auditory information processing related to change detection. Traditional scalp-level EEG methods consistently find attenuated MMN in patients with chronic but not first-episode schizophrenia. In the current paper, we use source-resolved method assess and hypothesize that more subtle changes can be identified this analysis method. Fifty-six antipsychotic-naïve schizophrenia (FEANS) (31 males, 25 females, mean age 24.6) 64 matched...

The aim of this study was to investigate the effective role silymarin either alone or in a combination with vitamin E and/or curcumin against toxic impact carbon tetrachloride (CCl4) induced liver injury results revealed that administration for 21 consecutive days, 24 h after CCl4 injection rats, markedly ameliorated DNA damaged and apoptosis markers rat livers, proinflammatory including tumor necrosis factor- α (TNF- α) C-reactive protein (CRP ) livers as well interleukin 6 (IL-6),...

This study evaluated the mechanistic sequel of aldehyde dehyrogenase (ALDH2) and Klotho protein in cyclophosphamide (CP)-induced cardiotoxicity rats protective effect astaxanthin (AST) against that sequel. A total 40 male Wistar albino were divided into four groups 10 animals each: Group 1 was injected intraperitoneally (i.p.) with normal saline for successive days. 2 5 days before after a single dose CP (200 mg/kg, i.p.). 3 received AST (50 mg/kg/day, i.p.) 4 as group 3. After last...

This study was performed to investigate the effect of curcumin on cardiac myosin-induced autoimmune myocarditis in rats and change thioredoxin (TRX) immunoreactivity cardiomyocytes following treatment. Twenty-four six-week-old male Wistar were randomly allocated into 4 groups 6 each. Group I received neither nor myosin. II an oral solution 1 g/kg/day daily, from day 21. To induce myocarditis, animals both group III IV injected by mg porcine myosin days 8. In addition, Serum levels creatine...

The critical role of CaMKIIδ isoforms in cardiac hypertrophy is well documented.This study was aimed to investigate the possible inhibitory effects aliskiren (ALS) and/or carvedilol (CAV) on expression experimental hypertrophy.Male Wistar albino rats were subcutaneously injected with isoproterenol (ISO) (5 mg/kg/day) for 4 weeks induce hypertrophy. Hypertrophied daily treated either ALS (10 mg/kg) CAV mg/kg). At end treatment, killed; blood and hearts collected assessing different...

One of the commonest antitumor drugs is cyclophosphamide (CP).CP that used in management many tumors and autoimmune disease as well polychemotherapy regimens immunosuppressive protocols.It doesn't only have a specific effect on cancer cells, but also it produces toxic effects.One most important side effects CP limits its use clinical practice dose dependent toxicity heart.The incidence cardiotoxicity at doses over 120-150 mg/kg 8-20% adults, 5% children.The heart failure after high varies...

The aim of this work was to study the possible cardiotoxicity two different doses 50 nm nano titanium dioxide (n-TiO2) and modulating effects use natural antioxidants carnosine melatonin. results showed that TiO2- NPs produced deleterious on rat cardiac tissue as confirmed by increased levels serum myoglobin, troponin-T CK-MB. Increased Inflammatory markers represented tumor necrosis factor alpha (TNF-α) Interleukin-6 (IL-6) also noticed. Caspase3 IGg were elevated compared control group in...

An accurate, sensitive and simple high-performance liquid chromatography (HPLC) assay with UV detection has been developed validated for the simultaneous determination of etoricoxib its internal standard (IS) flurbiprofen in plasma developed. After samples clean up by protein precipitation, followed solvent evaporation reconstitution mobile phase, an aliquot resulted solution were injected into chromatograph. Peaks eluted from a Novapak-C8 column using phase consisting acetic acid:...