Metformin is one of the most commonly prescribed antidiabetic drugs. A recent clinical study has highlighted protective role metformin against cardiac complications in type I diabetes. Curcumin a natural compound with well-known antioxidant and anti-inflammatory properties. The present was designed to investigate possible curcumin potentiating metformin`s putative effects. Rats received single injection 52.5 mg/kg streptozocin diabetic rats were treated (200 mg/kg/day), (100 mg/kg/day) their...

Abstract Naloxone is a non-selective opiate receptor antagonist that mainly used in the management of acute opioid overdose or intoxication. Previously, naloxone has been shown to have anti-inflammatory and antioxidant properties. Concanavalin A (Con A) model common well established animal autoimmune hepatitis closely resembles pathological alterations occur human. The present study demonstrates low dose (LD NX) ability improve hepatic function attenuate damage induced by Con as indicated...

In our study, the potential modulatory effect of zeolite on aluminum chloride used to induce Alzheimer's disease was investigated. Rats were divided into four groups (control group, and group). Aluminum treatment characterized by decreasing latency for animals step dark section in passive avoidance test, increasing escape climb platform spent significantly less time defined part Morris water maze test .Also, increase acetylcholinesterase content, Amyloid beta oxidative stress markers...

Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas pharmaceutical Science including drugs, community pharmacy, hospital clinical compounding consultant internet veterinary nuclear military pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics,...

Abstract This study was designed to investigate the potential of extracellular adenosine 5′-triphosphate (ATP) via P2 X 7 receptor activate renal fibrotic processes in rats. The present demonstrates that administration ATP rapidly activated transforming growth factor-β (TGF-β) induce phosphorylation Smad-2/3. Renal connective tissue factor (CTGF) and inhibitor metalloproteinase-1 (TIMP-1) mRNA protein expressions were also increased following administration. A decrease TGF-β amount serum as...

Proton pump inhibitors (PPIs) are one of the most commonly prescribed medications. However, PPI usage is linked to a higher risk both acute and chronic renal damage by mechanisms not entirely known. The present study demonstrates that omeprazole (10 mg/kg body weight, i.p.) causes TGF-β/Smad signaling activation subsequent expression profibrotic genes CTGF TIMP-1 in rat kidney. Increased production accompany cascade. simultaneous treatment TGF-β inhibitor, disitertide (P144) (1 weight...

Male infertility is one of the most important health problems.It can be caused by drugs, especially those used for mental illnesses.Poor nutrition also affect male fertility as well health.L-carnitine a natural supplement shows promising effect in preserving fertility.The purpose this study was to test whether L-carnitine protective against lithium and carbamazepine induced protein malnourished rats.Forty-eight adult albino rats were divided six groups.Lithium administered combination given...

Cyclosporin A (CsA) is one of the most efficient immunosuppressive drugs that are widely used in organ transplantation. However, its clinical use often limited by acute and chronic nephrotoxicity. One possible mechanisms CsA-induced nephrotoxicity thought to be reactive oxygen species (ROS) formation. The present work was designed investigate potential protective effect wheat germ oil (WGO) as antioxidant on rats. It found treatment animals with CsA alone significantly increased levels blood...

Abstract Naloxone is a non-selective opiate receptor antagonist that mainly used in the management of addiction. Previously, naloxone has been shown to have anti-inflammatory and antioxidant properties. A popular well-known animal model autoimmune hepatitis closely matches pathogenic changes take place humans Concanavalin (Con A) model. The present study demonstrates low dose (LD NX) ability improve hepatic function attenuate damage induced by Con as indicated substantial decrease serum...

Extracellular ATP is a potent signaling molecule that regulates different biological activities including proliferation, differentiation as well cell death.Several studies have implicated extracellular mitogenic agent in various cells vitro.Herein, we aimed to investigate the involvement of processes vivo via stimulation P2X7Rs rat kidney.Results from current study showed administration caused rapid activation ADAM-17 with subsequent phosphorylation EGFR and ERK-1/2.Cyclin B1 expression...

Proton pump inhibitors (PPIs) are a group of drugs that is commonly prescribed worldwide.However, the use PPIs accompanied with acute kidney injury and chronic disease by mechanisms not entirely known.In present study, omeprazole administration was found to cause rapid phosphorylation ERK1/2 signaling cascade an increase in cyclin B1expression rat kidney.In addition, enhancedthe activity A disintegrin metalloproteinase-17 (ADAM-17) ane ofepidermal growth factor receptor (EGFR).Interestingly,...

This research was designed to assess the inhibitory action of aliskiren, L-carnitine, and their combined treatment on JAK2/STAT3/SOCS3 signaling pathway in cardiac hypertrophy induced by isoproterenol injection rats.Wistar rats were injected with (5 mg/kg/day) for 15 days induction hypertrophy.Hypertrophied animals concurrently treated daily aliskiren (50 mg/kg) and/or L-carnitine (200 mg/kg).Either or significantly reduced elevated relative heart weight a concomitant reduction brain...