A5003789364- Hormonal and reproductive studies
- Liver Diseases and Immunity
- Coenzyme Q10 studies and effects
- Liver Disease Diagnosis and Treatment
- Electromagnetic Fields and Biological Effects
- Effects of Radiation Exposure
- Inflammatory mediators and NSAID effects
- Liver Disease and Transplantation
- Carcinogens and Genotoxicity Assessment
- Lipid metabolism and biosynthesis
- Complementary and Alternative Medicine Studies
- Bone Metabolism and Diseases
- HER2/EGFR in Cancer Research
- Cardiac Imaging and Diagnostics
- Quinazolinone synthesis and applications
- Cardiac Ischemia and Reperfusion
- Helicobacter pylori-related gastroenterology studies
- Traditional Chinese Medicine Analysis
- Nigella sativa pharmacological applications
- Synthesis and biological activity
- Aluminum toxicity and tolerance in plants and animals
- Biofield Effects and Biophysics
- Cholinesterase and Neurodegenerative Diseases
- Machine Learning in Healthcare
- Eicosanoids and Hypertension Pharmacology
Egyptian Russian University
2017-2024
Egyptian Atomic Energy Authority
2001-2024
Al Azhar University
2023
Bridge University
2023
Fayoum University
2019
National Water Research Center
2011
National Research Centre
2003
Abstract Naloxone is a non-selective opiate receptor antagonist that mainly used in the management of acute opioid overdose or intoxication. Previously, naloxone has been shown to have anti-inflammatory and antioxidant properties. Concanavalin A (Con A) model common well established animal autoimmune hepatitis closely resembles pathological alterations occur human. The present study demonstrates low dose (LD NX) ability improve hepatic function attenuate damage induced by Con as indicated...
Prostatic inflammation is the driving force in benign prostatic hyperplasia (BPH). This work investigated potential modulatory effect of COX-2 inhibition on ADAM-17/EGFR/ERK1/2 axis.Adult male Wistar rats were used.Celecoxib (10 and 20 mg/kg; i.p.) was injected i.p. daily for three weeks. Testosterone (TST) (3 s.c.) used to induce BPH.Prostatic assessed by organ weight histopathology. Inflammatory mediators measured using ELISA technique. Protein analysis performed western blotting...
Abstract In a search for new antioxidants, set of iodoquinazolinone derivatives bearing benzenesulfonamide moiety and variable acetamide pharmacophores 5–17 were designed synthesized. The structures the synthesized compounds confirmed based on spectral data. Compounds 5 – 17 screened using in vitro assay their antioxidant potential acetylcholinesterase (AChE) inhibitory activity. 2-(6-iodo-4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydroquinazolin-2-ylthio)- N -(pyrazin-2-yl) 14 was most active...
Peptic ulcer (PU) is a common gastrointestinal disorder that causes damage to the stomach and duodenal mucosal lining. The goal of this research look into impact empagliflozin (Empa) on peptic ulcers utilizing an indomethacin (Indo) non-diabetic rat model. Adult male Wistar rats were used divided three groups. Group I (control group), group II (Indo group) received Indo at dose 100 mg/kg/day (p.o) induce PU, III (Empa + Empa 10 mg/kg (p.o.) daily for 14 days 1 hr before scarification. Before...
Abstract Endothelial vascular injury is one of the most pivotal disorders emerging during radiotherapy. It crucial to rely on strong antioxidants defend against damage. The current study was carried out investigate ameliorative effect ubiquinol (Ubq) gamma (γ)-radiation induced aortic and coronary changes, with highlighting its role in suppression p38 mitogen activated protein kinase (MAPK). Exposure γ-radiation adopted as a potent detrimental model that induces tissue Concisely, male albino...
Epidermal growth factor receptor (EGFR) is a tyrosine kinase that often increased in malignancies such as non–small cell lung cancer, metastatic colorectal head and neck pancreatic breast cancer. EGFR activity may be enhanced by different ways. These include typical mutations truncations the extracellular domain, domain. Overactivation of downstream ERK1/2 signaling pathway occurs result these abnormalities. Cancer proliferation aided chronic start advancement cycle, which triggered once...
Benign prostatic hyperplasia (BPH) is one of the most prevalent clinical disorders in elderly. Probenecid (Prob) a well-known FDA-approved therapy for gout owing to its uricosuric effect. The present study evaluated use Prob BPH as COX-2 inhibitor. (100 and 200 mg/kg) was intraperitoneally injected into male Wistar rats daily 3 weeks. In second week, testosterone (3 subcutaneously induce BPH. Compared with BPH-induced rats, treatment reduced prostate weight index improved histopathological...
Alzheimer's disease (AD) is a global chronic neuro-disorder categorized by the lack of cognition and memory.Here, present exploration was intended to reveal ameliorative properties Blueberry (BB) against aluminum chloride (AlCl3)-provoked neurobehavioral pathological changes in AD animals.Eighteen male rats were allocated into three groups.Control group; received saline, AlCl3 (70 mg/kg/day orally) for 28 days + BB group, treated with (0.4 mg/kg/day, days, 1 h after injection AlCl3.At end...
A lipid producing isolate (LPI 65) was identified by a molecular genetics technique as Pichia occidentalis MH879824.1 investigated for its ability to produce biodiesel. The screened accumulate lipids within the cells culturing on nitrogen-limited medium (NLM) and using Sudan black B staining technique. Estimation of content % performed. effect different glucose concentrations in NLM dry biomass weight were conducted results showed that best concentration 70 g/L. possibility wastes such sugar...
Abstract Naloxone is a non-selective opiate receptor antagonist that mainly used in the management of addiction. Previously, naloxone has been shown to have anti-inflammatory and antioxidant properties. A popular well-known animal model autoimmune hepatitis closely matches pathogenic changes take place humans Concanavalin (Con A) model. The present study demonstrates low dose (LD NX) ability improve hepatic function attenuate damage induced by Con as indicated substantial decrease serum...
Background and Purpose: One of the most bothersome disorders affecting elderly men is benign prostatic hyperplasia (BPH). Prostatic inflammation driving force behind hyperplasia. A pro-inflammatory response in prostate has been linked to a number cytokines growth factors. The current study evaluated association between BPH. Experimental Approach: standard selective COX-2 inhibitor; Celecoxib (CXB) (10 20 mg/kg) was injected i.p. daily into male Wister rats for three weeks. From second week,...