A5039782428- Synthesis and biological activity
- Computational Drug Discovery Methods
- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Natural Compounds
- Advancements in Transdermal Drug Delivery
- Hormonal and reproductive studies
- Dermatology and Skin Diseases
- Alzheimer's disease research and treatments
- Renin-Angiotensin System Studies
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Asthma and respiratory diseases
- Cancer Mechanisms and Therapy
- Vitamin C and Antioxidants Research
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Biological Evaluation
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Microbial infections and disease research
- Urinary Bladder and Prostate Research
- Bacteriophages and microbial interactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Drug-Induced Hepatotoxicity and Protection
- Lung Cancer Treatments and Mutations
- Legume Nitrogen Fixing Symbiosis
Beni-Suef University
2015-2025
Fayoum University
2021-2024
German University in Cairo
2024
Ain Shams University
2019
Research Institute of Ophthalmology
2017-2019
Environment and Plant Protection Research Institute
2017
Misr University for Science and Technology
2016
Cairo University
2001-2003
Louisiana State University Agricultural Center
1987
Novel tolmetin derivatives 5a-f to 8a-c were designed, synthesised, and evaluated for antiproliferative activity by NCI (USA) against a panel of 60 tumour cell lines. The cytotoxic the most active 5b 5c was examined HL-60, HCT-15, UO-31 Compound found be potent derivative lines with IC50 values 10.32 ± 0.55, 6.62 0.35, 7.69 0.41 µM, respectively. Molecular modelling studies towards VEGFR-2 site performed. displayed high inhibitory (IC50 = 0.20 µM). It extremely reduced HUVECs migration...
The discovery of drugs capable inhibiting SARS-CoV-2 is a priority for human beings due to the severity global health pandemic caused by COVID-19. To this end, repurposing FDA-approved such as NSAIDs against COVID-19 can provide therapeutic alternatives that could be utilized an effective safe treatment anti-inflammatory activity also advantageous in COVID-19, it was found responsible provoking inflammatory cytokine storms resulting lung damage. In study, 40 were evaluated through molecular...
The global prevalence of COVID-19 disease and the overwhelming increase in death toll urge scientists to discover new effective drugs. Although drug discovery process is a challenging time-consuming, fortunately, plant kingdom was found have many active therapeutics possessing broad-spectrum antiviral activity including those candidates against severe acute respiratory syndrome coronaviruses (SARS-CoV). Herein, nine traditional Chinese medicinal constituents from different origins...
The global breakout of COVID-19 and raised death toll has prompted scientists to develop novel drugs capable inhibiting SARS-CoV-2. Conducting studies on repurposing some FDA-approved glucocorticoids can be a promising prospective for finding treatment COVID-19. In addition, the use anti-inflammatory drugs, such as glucocorticoids, is pivotal step in critical cases COVID-19, they provoke an inflammatory cytokine storm, damaging lungs. this study, 22 were identified through silico (molecular...
Hydroxyethylamine and hydroxyethylene moieties of β-blockers exert potential SARS-CoV-2 inhibitory effects: rational-based design in silico , vitro SAR Studies.
A series of coumarin derivatives were designed, synthesized, and evaluated for their antiproliferative activity. Compound 3e exhibited significant activity was further at five doses the National Cancer Institute. It effectively inhibited vascular endothelial growth factor receptor-2 (VEGFR-2) with an IC50 value 0.082 ± 0.004 µM compared sorafenib. While compound significantly downregulated total VEGFR-2 its phosphorylation, it markedly reduced HUVEC's migratory potential, resulting in a...
The foremost target of the current work was to formulate and optimize a novel bergamot essential oil (BEO) loaded nano-phytosomes (NPs) then combine it with spironolactone (SP) in order clinically compare efficiency both formulations against acne vulgaris. BEO-loaded NPs were fabricated by thin-film hydration optimized 32 factorial design. NPs' assessments conducted measuring entrapment percent (EE%), particle size (PS), polydispersity index (PDI), zeta potential (ZP). In addition, selected...
Abstract Drug repurposing of well‐established drugs to be targeted against lung cancer has been a promising strategy. Bosentan is an endothelin 1 (ET‐1) blocker widely used in pulmonary hypertension. The current experiment intends inspect the anticancer and antiangiogenic mechanism bosentan targeting epidermal growth factor receptor (EGFR) /extra‐cellular Signal Regulated Kinase (ERK) /c‐Jun/vascular endothelial (VEGF) carcinogenic pathway. BALB/c mice were randomized into four groups, first...
In nosocomial settings, vancomycin-resistant Enterococcus faecalis is a major health threat leading to increased morbidities, mortalities, and treatment costs. Nowadays, several approaches are under investigation enhance the activity of or replace traditional antibiotics. Bacteriophage therapy was sought as potential approach for combating E. infections. The present study focuses on isolating characterizing bacteriophage against clinical multi-drug resistant (MDR) strain Lb-1492. phage...
Abstract Background The dissemination of multi-drug-resistant bacteria, particularly Methicillin-resistant Staphylococcus aureus (MRSA), necessitates exploring new alternatives for their control. Bacteriophages are promising antibiotic with unique features. Here, we have performed a comprehensive characterization newly isolated bacteriophage (PSK) and compared its therapeutic potential vancomycin in vivo. Methods Sewage samples were processed enriched the MRSA S. SK1 strain search isolation...
Rebamipide is a quinolone derivative that has been commonly used for the treatment of gastric and duodenal ulcers. However, molecular mechanisms rebamipide against acetic acid-evoked colitis have not adequately examined. Hence, current study aimed to investigate ameliorative effect in rat model ulcerative linked pertaining SIRT1/FoxO3a/Nrf2 PI3K/AKT pathways. Herein, was induced by intrarectal administration 3% acid solution saline (v/v) while administered oral gavage (100 mg/kg/day) seven...
FMS-like tyrosine kinase 3 (FLT3) mutations occur in approximately 30% of acute myeloid leukemia (AML) patients. In the current study, oxindole chemotype is employed as a structural motif for design new FLT3 inhibitors potential hits AML irradiation. Cell-based screening was performed with 18 derivatives and 5a-c inhibited 68%-73% 83%-91% internal tandem duplication (ITD)-mutated MV4-11 cell growth 48- 72-h treatments while only 0%-2% 27%-39% wild-type THP-1 cells. The most potent compound...