A5006048385- Synthesis and biological activity
- Click Chemistry and Applications
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Biological Evaluation
- Seaweed-derived Bioactive Compounds
- Nitric Oxide and Endothelin Effects
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Essential Oils and Antimicrobial Activity
- COVID-19 Clinical Research Studies
- Protein Degradation and Inhibitors
- Cancer Treatment and Pharmacology
- Synthesis of Tetrazole Derivatives
- Protein Tyrosine Phosphatases
- Eicosanoids and Hypertension Pharmacology
- Chemical Synthesis and Reactions
- Histone Deacetylase Inhibitors Research
- Lung Cancer Treatments and Mutations
- Sulfur Compounds in Biology
- Advanced Breast Cancer Therapies
- RNA and protein synthesis mechanisms
Port Said University
2019-2024
Minia University
2014-2023
Electronics Research Institute
2019
Ain Shams University
2019
Military Technical College
2019
Academy of Scientific Research and Technology
2019
University Hospital Magdeburg
2019
Al Baha University
2017-2019
Arab Academy for Science, Technology, and Maritime Transport
2019
Cornell University
2017
In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) commenced in Wuhan, China and affected around 210 countries territories a matter weeks. It has phylogenetic similarity to SARS-CoV it was named 2 (SARS-CoV-2) caused severe acute respiratory syndrome that could lead death. One the promising therapeutic strategies for virus infection is search enzyme inhibitors among natural compounds using molecular docking order obtain products with minimal side effects. COVID-19 main...
A promising alternative to address the problem of acquired drug resistance is rely on combination therapies. Identification right combinations often accomplished through trial and error, a labor resource intensive process whose scale quickly escalates as more drugs can be combined. To this problem, we present broad computational approach for predicting synergistic using easily obtainable single efficacy, no detailed mechanistic understanding function, limited testing. When applied mutant...
SARS-CoV-2 is a novel coronavirus that was first identified during the outbreak in Wuhan, China 2019. It an acute respiratory illness can transfer among human beings. Natural products provide rich resource for antiviral drugs. They interfere with viral proteins such as proteases, polymerases, and entry proteins. Several naturally occurring flavonoids were reported to have activity against different types of RNA DNA viruses. A methanolic extract Manilkara hexandra (Roxb.) Dubard leaves...
Breast cancer is the most predominant tumor in women. Even though current medications for distinct breast subtypes are available, non-specificity of chemotherapeutics and chemoresistance imposes major obstacles treatment. Although combretastatin A-4 (CA-4) has been well-reported to have potential anticancer activity, vivo studies CA-4 reveal a decrease its activity. In this respect, series analogues designed, from which one analog...
FMS-like tyrosine kinase 3 (FLT3) mutations occur in approximately 30% of acute myeloid leukemia (AML) patients. In the current study, oxindole chemotype is employed as a structural motif for design new FLT3 inhibitors potential hits AML irradiation. Cell-based screening was performed with 18 derivatives and 5a-c inhibited 68%-73% 83%-91% internal tandem duplication (ITD)-mutated MV4-11 cell growth 48- 72-h treatments while only 0%-2% 27%-39% wild-type THP-1 cells. The most potent compound...
Protein kinases regulate cellular activities and make up over 60% of oncoproteins proto-oncoproteins. Among these kinases, FLT3 is a member class III receptor tyrosine kinase family which abundantly expressed in individuals with acute leukemia. Our previous oxindole-based hit has particular affinity toward (IC
Cancer is appraised as one of the predominant reasons for demise worldwide. Owing to continued resistance anti-topoisomerases, worldwide challenge discovery new drugs and maintenance their topoisomerase sensitivity. Therefore, main goal this work assess potential anti-cancer effect ethyl acetate extracts derived from different broth media endophytic Aspergillus terreus AArEF2 isolated Artemisia arboresscens L. versus HepG-2 MCF-7 cell lines estimate ability most potent cytotoxic extract...
Abstract The classical Lossen rearrangement converts activated hydroxamic acids to isocyanates that form numerous products upon their reaction with nucleophiles. We report a simple and highly efficient method of using Heck conditions initiate rearrangements acids. In addition, occur in the presence palladium(II) acetate or triethylamine, components reaction, alone. A potential mechanism is provided explain this reactivity these results show reactions under same may provide new methods for...
Drug repurposing is a fast way to rapidly discover drug for clinical use. In such circumstances of the spreading highly contagious COVID-19, searching already known drugs worldwide demand. this study, many were evaluated by molecular docking. Among test compounds, aliskiren (the best), dipyridamole, mopidamol and rosuvastatin showed higher energies binding than that co-crystallized ligand N3 with COVID-19 main protease M pro . Rolitetracycline best catalytic center enzyme through CYS 145 HIS...
Coronavirus (CoV) is a positive RNA genome virus causing global panic nowadays.
Several studies are now underway as a worldwide response for the containment of COVID-19 outbreak; unfortunately, none them have resulted in an effective treatment.
Abstract Ethanol extracts of Caulerpa racemose (Forsskål) J.Agardh, 1873, Dictyopteris acrostichoides (J.Agardh) Bornet, 1885, Halimeda opuntia (Linnaeus) J.V.Lamouroux, 1816, and Polycladia myrica (S.G.Gmelin) Draima, Ballesteros, F.Rousseau & T.Thibaut, 2010, were tested for their cytotoxicity against human hepatoma, breast adenocarcinoma, colon adenocarcinoma cell lines. displayed with IC 50 values 11.65, 9.28, 16.86 µg/ml, respectively, in comparison to doxorubicin as a positive...
A series of novel 1-(3',4',5'-trimethoxybenzoyl)-3,5-diarylpyrazoline derivatives were synthesized and evaluated for their cytotoxic properties on different cancer cell lines tubulin polymerization inhibitory activity. Compounds 6d 6e exhibited remarkable activity against with good Compound moderate selectivity toward renal breast subpanels ratios 3.06 5.11, respectively, at the cytostatic (TGI) level. achieved IC(50) values 17 40 µM, respectively. The photomicrographs made compounds...
The clearance of microsphere-bound fluorescein from the vitreous was studied in rabbits to evaluate microspheres as a controlled-release drug delivery system. Microspheres different combinations copolymers lactic and glycolic acid were injected intravitreally three groups rabbits. High concentrations detected all within 24 hours. By 5 days, levels had gradually decreased, but they remained measurable up 16 days which lactide been injected. Clearance more rapid lactide/glycolide combination...
Nitroxyl (HNO) reacts with thiols, and this reactivity requires the use of donors 1-nitrosocyclohexyl acetate, pivalate, trifluoroacetate, forming a new group. These acyloxy nitroso compounds inhibit glyceraldehyde 3-phosphate dehydrogenase (GAPDH) by reduction reversible active site disulfide irreversible sulfinic acid or sulfinamide modification at Cys244. Addition these to AhpC C165S yields modification. A potential mechanism for transformations includes nucleophilic addition protein...