A5033903086- Mesenchymal stem cell research
- Drug-Induced Hepatotoxicity and Protection
- Tissue Engineering and Regenerative Medicine
- Liver Disease Diagnosis and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Cancer Cells and Metastasis
- Acute Kidney Injury Research
- Cancer therapeutics and mechanisms
- Sepsis Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Liver Disease and Transplantation
- Bioactive Compounds and Antitumor Agents
- Estrogen and related hormone effects
- PI3K/AKT/mTOR signaling in cancer
- Genomics, phytochemicals, and oxidative stress
- Liver physiology and pathology
- Hepatitis C virus research
- Nigella sativa pharmacological applications
- Nephrotoxicity and Medicinal Plants
- Pluripotent Stem Cells Research
- Synthesis and biological activity
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Phytochemistry and Bioactive Compounds
- Pharmacological Receptor Mechanisms and Effects
Minia University
2013-2025
NOSM University
2023-2024
Menoufia University
2023-2024
University of Toyama
2012-2024
Thunder Bay Regional Health Sciences Centre
2024
Eugenol is a phytochemical present in different plant products, e.g., clove oil. Traditionally, it used against number of disorders and was suggested to have anticancer activity. In this study, the activity eugenol evaluated human cervical cancer (HeLa) cell line proliferation examined after treatment with various concentrations durations. Cytotoxicity tested using lactate dehydrogenase (LDH) enzyme leakage. order assess eugenol's potential act synergistically chemotherapy radiotherapy,...
Insulin resistance contributes to several disorders including type 2 diabetes and cardiovascular diseases. Carpachromene is a natural active compound that inhibits α-glucosidase enzyme. The aim of the present study investigate potential activity carpachromene on glucose consumption, metabolism insulin signalling in HepG2 cells resistant model. A cell model (HepG2/IRM) was established. Cell viability assay HepG2/IRM performed after carpachromene/metformin treatment. Glucose concentration...
The amnion membrane is developed from embryo-derived cells, and amniotic cells have been shown to exhibit multidifferentiation potential. These represent a desirable source for stem variety of reasons. However, date very few molecular analyses amnion-derived reported, efficient markers isolating the remain unclear. This paper assesses characterization as by examining stemness marker expressions epithelial mesenchymal flow cytometry, immunocytochemistry, quantitative PCR. Flow cytometry...
SARS-CoV-2 is one of the coronavirus families that emerged at end 2019. It infected respiratory system and caused a pandemic worldwide. Fluoroquinolones (FQs) have been safely used as antibacterial agents for decades. The antiviral activity FQs was observed. Moreover, substitution on C-7 position ciprofloxacin enhanced its activity. Therefore, this study aims to investigate 7-(4-(N-substituted-carbamoyl-methyl)piperazin-1yl)-chalcone in comparison with against main protease (Mpro ).Vero...
The lack of effective antiviral treatments against SARS-CoV-2 is a significant limitation in the fight COVID-19 pandemic. Single-drug regimens have so far yielded limited results, indicating that combinations antivirals might be required, as previously seen for other RNA viruses.
Pantoprazole has an antioxidant function against reactive oxygen species (ROS). Vincamine, a herbal candidate, is indole alkaloid of clinical use brain sclerosis. The aim the present experiment to evaluate, on molecular level for first time, value vincamine in addition pantoprazole treating experimentally induced renal ischemia/reperfusion injury (IRI). One-hundred-and-twenty-eight healthy male Wistar albino rats were included. Serum creatinine, blood urea nitrogen, and malondialdehyde...
Metastatic breast cancer is an incurable form of that exhibits high levels epithelial-mesenchymal transition (EMT) markers. Angiotensin II has been linked to various signaling pathways involved in tumor cell growth and metastasis. The aim this study investigate, for the first time, anti-proliferative activity azilsartan, angiotensin receptor blocker, against lines MCF-7 MDA-MB-231 at molecular level. Cell viability, cycle, apoptosis, colony formation, migration assays were performed. RT-PCR...
Cisplatin is a commonly used chemotherapeutic agent; however, its potential side effects, including gonadotoxicity and infertility, are critical problem. Oxidative stress has been implicated in the pathogenesis of cisplatin-induced testicular dysfunction. We investigated whether kinetin use at different concentrations could alleviate gonadal injury associated with cisplatin treatment, an exploration involvement antioxidant capacity. Kinetin was administered doses 0.25, 0.5, 1 mg/kg, alone or...
Renal ischemia/reperfusion (IR) injury is characterized by an unexpected impairment of blood flow to the kidney. Azilsartan angiotensin receptor blocker that approved for management hypertension. The present study aimed investigate, on molecular basics, nephroprotective activity azilsartan renal IR in rats. Rats were assigned into four groups: (1) Sham group, (2) (3) and (4) IR/Azilsartan-treated group. Histological examination function evaluated. Levels KIM-1, HMGB1, caspase 3, GPX, SOD,...
Abstract Purpose Globally, sepsis, which is a major health issue resulting from severe infection-induced inflammation, the fifth biggest cause of death. This research aimed to evaluate, for first time, molecular effects gabapentin's possible nephroprotective potential on septic rats by cecal ligation and puncture (CLP). Methods Sepsis was produced CLP in male Wistar rats. Evaluations histopathology renal function were conducted. MDA, SOD, GSH, TNF-α, IL-1β, IL-6 levels measured. qRT-PCR...
Idiopathic pulmonary fibrosis is a progressive, irreversible lung disease that leads to respiratory failure and death. Vincamine an indole alkaloid obtained from the leaves of Vinca minor acts as vasodilator. The present study aims investigate protective activity vincamine against EMT in bleomycin (BLM)-induced via assessing apoptotic TGF-β1/p38 MAPK/ERK1/2 signaling pathways. In bronchoalveolar lavage fluid, protein content, total cell count, LDH were evaluated. N-cadherin, fibronectin,...
Testicular torsion carries the ominous prospect of inducing acute scrotal distress and perilous consequence testicular atrophy, necessitating immediate surgical intervention to reinstate vital perfusion, notwithstanding paradoxical detrimental impact reperfusion. Although no drugs have secured approval for this urgent circumstance, antioxidants emerge as promising candidates. This study aspires illustrate influence eprosartan, an AT1R antagonist, on in rats. Wistar albino rats were...
Abstract Sepsis is a pathological and biochemical disorder induced by numerous infections, leading to critical illness high mortality rate worldwide. Vincamine an indole alkaloid compound obtained from the leaves of Vinca minor. The present study aims investigate hepato-protective activity vincamine during colon ligation puncture (CLP)-induced sepsis at molecular level. was using CLP model. Liver function enzymes such as ALT AST were analyzed. hepatic antioxidant status (SOD GSH), lipid...
Abstract The defect in the hepatobiliary transport system results an impairment of bile flow, leading to accumulation toxic compounds with subsequent liver disorders. Vincamine, a plant indole alkaloid that is utilized as dietary supplement, has been known for its promising pharmacological activities. For first time, present study was planned estimate, at molecular level, potentiality vincamine against alfa-naphthyl isothiocyanate (ANIT)-induced hepatic cholestasis. Liver function tests were...
Nitric oxide (NO) and inducible nitric synthase enzyme (iNOS) have been implicated in various tumors. Hepatocellular carcinoma is a highly aggressive form of solid tumor. The lack effective therapy necessitates the introduction novel therapeutic strategies to counter this disease. Nigella sativa (NS) has shown specific health benefits. aim study was investigate vivo modulation iNOS pathway by NS ethanolic extract (NSEE) implications effect as an antitumor approach against diethylnitrosamine...
For hepatic failure, stem cell transplantation has been chosen as an alternative therapy, especially for mesenchymal cells (MSCs). The aim of this study was to investigate the effect eugenol (EUG) on in vivo antifibrotic activity adipose tissue-derived MSCs (AT-MSCs) and underlying mechanism. After characterization MSCs, rats were divided into five groups, Group 1 (normal control), 2 (CCl4), 3 (CCl4 + AT-MSCs), 4 EUG) 5 AT-MSCs EUG). Biochemical histopathological investigations performed....
Ischemia/reperfusion injury (IRI) in the kidney is most common cause of acute renal dysfunction through different cell damage mechanisms. This study aimed to investigate, on molecular basics for first time, effect pantoprazole IRI rats. Different biochemical parameters and oxidative stress markers were assessed. ELISA was used estimate proinflammatory cytokines. qRT-PCR western blot investigate gene protein expression. Renal histopathological examination also performed. resulted tissue...
Severe burn injuries create large skin defects that render the host susceptible to bacterial infections. Burn wound infection often causes systemic sepsis and severe septicemia, resulting in an increase mortality of patients with injuries. Therefore, appropriate care is important prevent improve patient outcomes. However, it difficult heal a third-degree injury. The aim this study was investigate whether hyperdry human amniotic membrane (HD-AM) could promote early granulation tissue...