Testicular torsion carries the ominous prospect of inducing acute scrotal distress and perilous consequence testicular atrophy, necessitating immediate surgical intervention to reinstate vital perfusion, notwithstanding paradoxical detrimental impact reperfusion. Although no drugs have secured approval for this urgent circumstance, antioxidants emerge as promising candidates. This study aspires illustrate influence eprosartan, an AT1R antagonist, on in rats. Wistar albino rats were...

Methotrexate (MTX) is a well-known anticancer drug that causes nephrotoxicity as side effect. To investigate the mechanisms by which paeonol, natural phenolic compound, can protect against MTX-induced nephrotoxicity, paeonol (100 mg/kg/day orally) was given to rats for 10 days, with or without MTX (20 mg/kg once i.p. at day 5). Compared control, caused nephrotoxic effects manifested increased serum urea and creatinine distortion in renal histological architecture, significant increase mean...

Paeonol, a phenolic ingredient in the genus Paeonia, possesses antioxidant and anti-inflammatory effects. Methotrexate (MTX) is commonly used chemotherapeutic agent; however, its germ cell damage critical problem. P-glycoprotein (P-gp), an efflux transporter, member of blood–testis barrier. The present study evaluated protective effect paeonol on MTX-induced testicular injury rats with exploration mechanism possible contribution P-gp such protection. Testicular weight, serum testosterone,...

Hepatic ischemia/reperfusion (HIR) is the most common type of liver injury following several clinical situations. Modulating oxidative stress and inflammation by Nrf2/HO-1 TLR4/MYD88/NF-κB pathways, respectively, involved in alleviating HIR injury. Paeonol a natural phenolic compound that demonstrates significant antioxidant anti-inflammatory effects. The present study explored possible protective effect paeonol against investigated its molecular mechanisms rats. Rats were randomly divided...

Liver dysfunction in sepsis is a major complication that amplifies multiple organ failure and increases the risk of death. Inflammation oxidative stress are main mediators pathophysiology sepsis. Therefore, we investigated role menthol, natural antioxidant, against sepsis-induced liver injury female Wistar rats. Sepsis was induced by cecal ligation puncture (CLP). Menthol (100 mg/kg) given intragastric 2 h after CLP. Blood samples tissues were collected 24 surgery. significantly (p < 0.05)...

The nephrotoxicity of cisplatin (CIS) is a significant complication that challenges its clinical applicability. epithelial to mesenchymal transition (EMT) may be included in the pathogenesis CIS-evoked nephrotoxicity. Therefore, current study aimed evaluate, for first time, possible protective effect AZL and/or AT-MSCs against CIS-induced EMT rats on molecular bases. Fifty-four healthy Wistar male albino were used this study. Different biochemical markers kidney function as well oxidative...

Methotrexate (MTX) is an effective chemotherapeutic agent against a wide range of tumors and autoimmune diseases; however, hepatotoxicity limits its clinical use. Oxidative stress inflammation have been implicated in the pathogenesis MTX-induced hepatotoxicity. Paeonol natural phenolic compound reported for antioxidant anti-inflammatory properties. The current study aimed to investigate protective effect paeonol rats various mechanisms that underlie this postulated effect. was administered...

Broccoli (Brassica oleracea) is reported to possess antioxidant activity that could potentially prevent oxidative damage tissues caused by many diseases. In the present study, we investigated preventive effect of broccoli leaf by-product extract (BL) on gentamicin-induced renal and hepatic injury measuring tissue activities morphological apoptotic changes. was thoroughly extracted with 70% methanol yield total (TME). The phenolic content (TPC) determined. Thirty male rats were divided into...

Despite its clinical value, cisplatin (CISP) is complicated by marked hepatotoxicity via inducing oxidative stress, inflammatory, and apoptotic pathways. This study aims to explore the protective impact of azilsartan (AZIL), an antihypertensive drug, in addition adipose tissue-derived mesenchymal stem cells (AD-MSCs) on CISP-induced hepatotoxicity. After characterization labeling AD-MSCs PKH26 dye, 54 Wistar male albino rats were randomly divided into nine groups: I (CONT), II (AZIL.H), III...

Pulmonary fibrosis is a life threating disease which requires an immediate treatment and due to the limited medications, this study focused on synthesizing series of quinoline-based pyrimidodiazepines

A series of novel 1,2,3-triazoles hybridized with two quinolin-2-ones, was designed and synthesized through click reactions. The structures the compounds were elucidated by NMR, IR, mass spectra in addition to elemental analysis. assessed for their antiapoptotic activity testis, as testicular torsion is main cause male infertility. This effect studied light decreasing tissue damage induced I/R testis rats using N-acetylcysteine (NAC) an reference. Compounds 6a-c most active hybrids...

5-fluorouracil (5-FU) is a widely used chemotherapeutic drug, but its hepatotoxicity challenges clinical use. Thus, searching for hepatoprotective agent highly required to prevent the accompanied hepatic hazards. The current study aimed investigate potential benefit and mechanisms of action rupatadine (RU), Platelet-activating factor (PAF) antagonist, in prevention 5-FU-related rats. Hepatotoxicity was developed male albino rats by single 5-FU (150 mg/kg) intra-peritoneal injection on 7th...

To investigate the potential protective role of montelukast (Mont) in pre-eclampsia rat model induced by L-NG-Nitro arginine methyl ester (L-NAME).Thirty-two pregnant female albino Wistar rats were assigned to four groups: control group: received vehicles; Mont (10 mg/kg/day, p.o.) from 6th 18th day gestation; L-NAME (50 i.p.) 9th Mont/L-NAME gestation and gestation. Placental, hepatic, renal malondialdehyde (MDA), total nitrites (NOx), interleukin 6 (IL-6), tumor necrosis factor (TNF)-α...

Abstract Parkinsonism is one of the most common aging neurodegenerative disorders. This study aims to compare therapeutic effect stem cell versus its conditioned medium in model. was induced by daily subcutaneous injection 0.5 mg/kg rotenone dissolved dimethyl sulfoxide for 28 days. Fifty rats were divided randomly into five groups: control, sulfoxide, Parkinsonism, cell‐treated, and medium‐treated groups. Midbrain specimens obtained histological, immunohistochemical, biochemical studies....

Methotrexate (MXT) is a chemotherapeutic drug that has been used in wide range of clinical practices. Unfortunately, the administration MXT during pregnancy may induce abortion, fetal deformities, and intrauterine growth retardation. Vitamin E an antioxidant agent can ameliorate free radical damage. The current work aimed to shed more light on possible protective effect vitamin against induced placental toxicity determine mechanisms; biochemically, histologically, immunohistochemically. Four...