A5001934184- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Synthesis and biological activity
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Chromatography
- Lipid Membrane Structure and Behavior
- Nail Diseases and Treatments
- Tuberculosis Research and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Computational Drug Discovery Methods
- Bee Products Chemical Analysis
- Dermatology and Skin Diseases
- RNA Interference and Gene Delivery
- Synthesis and Reactivity of Heterocycles
- Plant Pathogens and Fungal Diseases
- Crystallization and Solubility Studies
- Antibiotic Resistance in Bacteria
- Inhalation and Respiratory Drug Delivery
- Ocular Surface and Contact Lens
- Inflammatory mediators and NSAID effects
- Protein purification and stability
- Mycobacterium research and diagnosis
- Dendrimers and Hyperbranched Polymers
King Faisal University
2016-2025
Becton Dickinson (United States)
2024
Lovely Professional University
2024
Vellore Institute of Technology University
2017-2024
Indian Institute of Horticultural Research
2024
Chettinad Academy of Research and Education
2024
Pharmaceutical Biotechnology (Czechia)
2022
Children's Hospital of Eastern Ontario
2022
Bridge University
2022
Minia University
2022
Preclinical Research & Development Appropriate translation and determination of the maximum recommended starting dose in human is a vital task new drug development research. Allometric scaling most frequently used approach for extrapolation based on normalization dose-to-body surface area. Misinterpretation allometric conversion safety factor application can lead to major problems calculating safe first-in-human clinical trials. Therefore, always necessitates careful consideration body area,...
Curcumin, an organic phenolic molecule that is extracted from the rhizomes of Curcuma longa Linn, has undergone extensive evaluation for its diverse biological activities in both animals and humans. Despite favorable characteristics, curcumin encounters various formulation challenges stability issues can be effectively addressed through application nanotechnology. Nano-based techniques specifically focused on enhancing solubility, bioavailability, therapeutic efficacy while mitigating...
The nose-to-brain drug-delivery system has emerged as a promising strategy to overcome the challenges associated with conventional drug administration for central nervous disorders. This emerging field is driven by anatomical advantages of nasal route, enabling direct transport drugs from cavity brain, thereby circumventing blood–brain barrier. review highlights significance features cavity, emphasizing its high permeability and rich blood supply that facilitate rapid absorption onset...
Nanoemulsion is one of the potential drug delivery strategies used in topical ocular therapy. The purpose this study was to design and optimize a nanoemulsion-based system improve therapeutic efficacy moxifloxacin ophthalmic delivery. Moxifloxacin nanoemulsions were prepared by testing their solubility oil, surfactants, cosurfactants. A pseudoternary phase diagram constructed titration technique obtained with four component mixtures Tween 80, Soluphor® P, ethyl oleate water. An experiment...
Tissue repair and wound healing are complex processes that involve inflammation, granulation, remodeling of the tissue. The potential various statins including atorvastatin (ATR) to improve effect was established. aim this study formulate evaluate efficacy topical application ATR-based nanoemulgel on healing. prepared formulations (ATR gel, ATR emulgel, nanoemulgel) were evaluated for their physical appearance, rheological behavior, in vitro drug release ex vivo permeation. wound-induced...
The potential role of naringenin (NAR), a natural flavonoid, in the treatment chronic wound has prompted present research to deliver drug nanoemulsion (NE) form, where synergistic chitosan was achieved through development chitosan-coated NAR NE (CNNE). consisted Capryol 90, Tween 20 and Transcutol P, which fabricated by low-energy emulsification method encapsulate within oil core. optimization formulated NEs performed using Box-Behnken statistical design obtain crucial variable parameters...
Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier systems to enhance the bioavailability of drugs. This study investigated prospects drug-loaded SLNs increase permeation and improve therapeutic potential clarithromycin in therapy. were formulated by high-speed stirring ultra-sonication method. Solubility studies carried out select stearic acid former, Tween 80 surfactant, Transcutol P cosurfactant. Clarithromycin-loaded SLN optimized fractional...
The burden of antibiotic resistance necessitates a continued search for new antimicrobials. We evaluated the antimicrobial activities novel benzothiazoles synthesized by our group. Antibacterial activity was in vitro Staphylococcus aureus, Bacillus subtilis, and Escherichia coli, while antifungal tested Candida albicans Aspergillus niger, expressed as minimum inhibitory concentration (MIC; µg/mL). MIC values benzothiazole compounds ranged from 25 to 200 µg/mL. Compounds 3 4 gave high...
In situ gels have been extensively explored as ocular drug delivery system to enhance bioavailability and efficacy. The objective of present study was design, formulate evaluate ion-activated in gel the penetration therapeutic performance moxifloxacin ophthalmic delivery. A simplex lattice design utilized examine effect various factors on experimental outcomes system. influence polymers (independent variables) such gellan gum (X 1 ), sodium alginate 2 HPMC 3 ) strength, adhesive force,...
Abstract: Selecting the most appropriate first-in-human and pharmacologically active dose for any new drugs or biologicals is a crucial step before starting clinical trial investigation in adult healthy human subjects. Extrapolation of between various rodent non-rodent animal species critical biomedical researchers during initial drug development. The objective this review to provide practical guidance on how allometric scaling based body surface area normalization can be effectively...