Nanoemulsion is one of the potential drug delivery strategies used in topical ocular therapy. The purpose this study was to design and optimize a nanoemulsion-based system improve therapeutic efficacy moxifloxacin ophthalmic delivery. Moxifloxacin nanoemulsions were prepared by testing their solubility oil, surfactants, cosurfactants. A pseudoternary phase diagram constructed titration technique obtained with four component mixtures Tween 80, Soluphor® P, ethyl oleate water. An experiment...

Tissue repair and wound healing are complex processes that involve inflammation, granulation, remodeling of the tissue. The potential various statins including atorvastatin (ATR) to improve effect was established. aim this study formulate evaluate efficacy topical application ATR-based nanoemulgel on healing. prepared formulations (ATR gel, ATR emulgel, nanoemulgel) were evaluated for their physical appearance, rheological behavior, in vitro drug release ex vivo permeation. wound-induced...

The purpose of this study was to fabricate biostable inorganic silver nanoparticles (AgNPs) using fresh peel (aqueous) extract Benincasa hispida. A fast, robust, and eco-friendly approach used for the synthesis AgNPs, where bioactive components B. hispida acted as reducing stabilizing agents. Synthesized AgNPs were characterized a UV–Vis spectrophotometer, Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), electron microscopy. synthesized exhibited maximum...

Natural products have been extensively used for treating a wide variety of disorders. In recent times, Brucine (BRU) as one the natural medications extracted from seeds nux vomica, was investigated its anticancer activity. As far we know, this is first study on BRU activity against skin cancer. Thus, rational work implemented to develop, optimize and characterize loaded ethosomal gel. Basically, thin film hydration method formulate preparations, by means Central composite design (CCD), which...

Curcumin is a poorly water-soluble drug that used for the treatment of inflammations, tumors, wound healing antioxidant and other diseases. In current manuscript, it successfully formulated into proniosome gels. The proniosomes are readily hydrated niosomal formulations using warm water. Proniosomes were prepared nonionic surfactants (tween 80, span 60) either solely or in combinations with cholesterol. produced homogenous size vesicular sizes >343 <1800 nm. encapsulation efficiency...

Background: Curcumin (Cur) possesses a variety of beneficial pharmacological properties including antioxidant, antimicrobial, anti-cancer and anti-inflammatory activities. Nevertheless, the low aqueous solubility subsequent poor bioavailability greatly limits its effectiveness. Besides, role myrrh oil as an essential in treating inflammatory disorders has been recently demonstrated. The objective current investigation is to enhance Cur efficacy via developing nanoemulgel, which helps improve...

Date palm fruit (Phoenix dactylifera) is reputed to have numerous biological activities, including anticancer properties. To utilize the great fortune of this fruit, current study aimed maximize its pharmacological activity. extract (DPE) Khalas cultivar was obtained in powder form and then formulated into nanoemulsion (NE). The optimized DPE-NE along with naked counterpart followed by studying their physical chemical A qualitative assessment total serum protein associated surface...

Oral therapy of tramadol, an opiate analgesic, undergoes extensive hepatic metabolism and requires frequent administration. Transdermal by virtue can overcome these issues improve the efficacy reduce abuse liability tramadol. The aim this research was to investigate possibility transdermal delivery tramadol formulating proniosome gel evaluate its therapeutic potential in vivo. effect formulation composition as well amount drug on physicochemical characteristics prepared proniosomes were...

Transdermal delivery of insulin is a great challenge due to its poor permeability through the skin. The aim current investigation was evaluate prospective loaded niosome emulgel as noninvasive system for transdermal therapy. A 23 full-factorial design used optimize by assessing effect independent variables (concentration paraffin oil, Tween 80 and sodium carboxymethyl cellulose) on dependent (in vitro release, viscosity in permeation). physical characteristics prepared formulations were...

The purpose of the present study was to explore influence a certain natural essential oil, namely eucalyptus as an anti-inflammatory agent in addition its prospective role enhancing action meloxicam reducing inflammation. As far we know, this has been first integration and oil into nanoemulgel formulation intended for topical use. Primarily, utilized developing nanoemulsion incorporating meloxicam. A 22 factorial design constructed using two independent variables (oil concentration...

Presently, antimicrobial resistance is of great risk to remarkable improvements in health conditions and infection management. Resistance various antibiotics has been considered a obstacle their usage, necessitating alternative strategies for enhancing the antibacterial effect. Combination therapy recognized as considerable strategy that could improve therapeutic influence agents. Therefore, aim this study was combine action compounds natural origin like fusidic acid (FA) cinnamon essential...

Administration of almotriptan as an oral therapy is largely limited because poor aqueous solubility and rather low bioavailability. The aim present investigation was to formulate mucoadhesive film improve the drug delivery desired therapeutic effects. Placebo films (F1-F8) were prepared by varying concentrations Proloc 15 (7.5-15% w/v) Eudragit RL 100/RS 100 (15-30% polymers. Physicomechanical pharmaceutical characteristics loaded (FA1-FA4) examined. Selected FA4 evaluated in vivo assessing...

Recent progression in investigational studies aiming to integrate natural products and plant oils developing new dosage forms that would provide optimal therapeutic effect. Therefore, the aim of present exploration was inspect influence jojoba oil boosting anti-inflammatory effect colchicine product. To our knowledge, there is no formulation comprising together form a niosomal emulgel preparation anticipated for topical application. Colchicine product extracted from Colchicum autumnale has...

Fusidic acid (FA) is renowned as an effective bacteriostatic agent obtained from the fungus Fusidium coccineum, used for treating various eye and skin disorders. The objective of present study was to develop, characterize, evaluate antibacterial activity a novel FA nanoemulgel topical application. Primarily, fusidic nanoemulsion formulations were fabricated using different concentrations myrrh essential oil, Tween 80 surfactant, Transcutol® P co-surfactant. A Box–Behnken design employed...

The present investigation aims to improve the antimicrobial influence of certain antibacterial drugs, namely, neomycin (NEO), exploiting benefits natural oils such as tea tree oil (TTO). Therefore, a distinctive nanolipid formulation, nanoemulsion (NE), was developed using Central Composite Factorial Design (CCD) approach depending on amount TTO and tween 80 surfactant. optimized NEO-NE formula exhibiting minimum globular size maximum in vitro release selected. For efficient topical...

Mupirocin is an antibacterial agent that has been documented to be effective in treating superficial skin infections. However, the main limitation of its application bacterial resistance. Therefore, there a need determine way potentiate efficiency. Accordingly, this obstacle led current investigation, which aims find improve therapeutic action mupirocin. This study focuses on integration tea tree oil with mupirocin and wound healing capacities. Distinct nanoemulsions (NEs) were developed...

Chronic inflammation in ulcerative colitis (UC) patients is the major risk factor for colitis-associated colon cancer (CAC). Recent evidences have shown that microRNAs (miRNAs) are implicated CAC pathogenesis. However, interaction of miRNAs with transcription factors alleviate has not been reported. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3′-diindolylmethane (DIM) were used to activate aryl hydrocarbon receptor (Ahr) azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced mice....