The nose-to-brain drug-delivery system has emerged as a promising strategy to overcome the challenges associated with conventional drug administration for central nervous disorders. This emerging field is driven by anatomical advantages of nasal route, enabling direct transport drugs from cavity brain, thereby circumventing blood–brain barrier. review highlights significance features cavity, emphasizing its high permeability and rich blood supply that facilitate rapid absorption onset...

The present work describes the formulation development of ophthalmic in situ gelling system using thermo-reversible polymer, i.e. Pluronic F 127 (PF127). Because high concentration (20 to 25%w/v) this polymer required for gelation causes irritation eye. So, reduce concentration, an attempt was made combine PF127 with other polymers like hydroxy propyl methyl cellulose (HPMC) as a viscosity increasing agent or carbopol 940, xanthan gum, and sodium alginate (high glucuronic acid content)...

Conventional eye drops show relatively low bioavailability due to poor precorneal contact time. In situ hydrogels are of great importance in providing sustained ocular drug delivery. By exhibiting elastic properties they resist drainage the leading longer times. present study an gelling thermoreversible mucoadhesive gel was formulated antibacterial agent, Moxifloxacin HCl using a combination poloxamer 407 and 188 with different polymers such as Xanthan gum Sodium alginate view increase...

The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 3(2) full factorial design employed with two polymers: 68 and Gelrite independent variables used combination 127. Gelation temperature, gel strength, bioadhesion force, viscosity vitro release after 1 10 h were selected dependent variables. loading 127 found have significant effect gelation...

Abstract: The emergence of lipid-based nanoparticulate systems has significantly reshaped the landscape drug delivery. This review encapsulates advancements, challenges, and potential delivery in modern therapeutics. Lipid-based nanoparticles, including liposomes, lipid solid harness biocompatibility biodegradability lipids to encapsulate deliver a diverse range therapeutic agents. platform offers solutions various such as enhancing solubility bioavailability, achieving controlled sustained...

: Nanotechnology, the manipulation of matter at nanoscale, has been an extraordinary scientific frontier that revolutionized various fields, with one most promising applications being in realm medicine. Nanomedicine, interdisciplinary field intersection nanotechnology and medicine, holds tremendous potential to transform landscape healthcare, diagnosis, treatment. This abstract delves into burgeoning advancements nanomedicine, highlighting its significance, benefits, ethical considerations....

SLNs and NLCs have remarkably wide range of properties which make them useful for several potential applications in drug delivery, clinical medicine, research, as well parenteral, dermal, pulmonary topical delivery drugs. The unique size-dependent the solid lipid nanoparticles at forefront rapidly developing field nanotechnology offering development new therapeutics having reduced toxic side effects increased treatment efficacy.

The objective of this work was design, characterization, and optimization controlled drug delivery system containing antibiotic drug/s. Osmotic chosen as system. porous osmotic pump tablets were designed using Plackett-Burman Box-Behnken factorial design to find out the best formulation. For screening three categories polymers, six independent variables for design. agent sodium chloride microcrystalline cellulose, pore forming lauryl sulphate sucrose, coating ethyl cellulose acetate...

Despite numerous scientific efforts many challenges need to be overcome in the ocular delivery because eyes have special and complex anatomic structures.The main problem with conventional dosage forms is poor bioavailability due minimum residence time, of various anatomical pathophysiological barriers prevailing eye.For this reason, much effort has been put into developing nanotechnology-based drug systems improve drugs by increasing precorneal time.Polymers thiol groups provide higher...

: Objective: To develop a gastroretentive in situ oral gel to improve the bioavailability of cephalosporin antibiotic drug, Cefuroxime Axetil. Methodology: Sodium alginate and pectin were ionic dependent forming polymer. Calcium chloride was used as complexing agent increase cross linking along with sodium citrate. Mucoadhesion enhanced help polymer HPMC K4M. Two factors three levels factorial design for optimization formulation using expert software version 7.1.6. The In system evaluated...

: The cosmetic industry, driven by innovation, constantly seeks safer, more effective, and sustainable products. However, regulatory hurdles often impede the introduction of innovative cosmetics. This paper explores convergence advanced technologies conformity, emphasizing need for collaborative, interdisciplinary approaches. Through an extensive review literature case studies, we reveal multifaceted challenges within industry. These encompass shifting consumer expectations, ingredient...

The emergence of lipid-based nanoparticulate systems has significantly reshaped the landscape drug delivery. This review aims to encapsulate advancements, challenges, and potential delivery in modern therapeutics. Lipid-based nanoparticles, including liposomes, lipid solid harness biocompatibility biodegradability lipids deliver a diverse range therapeutic agents. platform offers solutions various such as enhancing solubility bio- availability, achieving controlled sustained release,...

Nifedipine is an antihypertensive BCS class II drug which has poor bioavailability when given orally. The objective of the present study was to increase nifedipine, by formulation and evaluation a buccoadhesive liquisolid system using magnesium aluminium silicate (Neusilin) as both carrier coating material dissolution media were selected based on solubility studies. A mixture carboxymethylcellulose sodium carbomer used mucoadhesive polymers. Buccoadhesive tablets prepared direct compression....

Objective: The purpose of the study was to formulate and evaluate thiolated chitosan based nanoparticulate mucoadhesive ophthalmic in situ gelling system prulifloxacin for bacterial keratoconjunctivitis. Keywords: Thiolated chitosan, gel, nanoparticles, ophthalmic, mucoadhesive, prulifloxacin.

The Fluidized hot melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated using low melting binder. effect of the binder properties and concentrations on agglomerate growth mechanisms were studied in this research paper with primary objective improvement solubility dissolution rate efavirenz melt-dispersion employing meltable hydrophilic carrier then to convert dispersion into flowable compressible granules yield rapidly dissolving tablet...

A fluidized hot melt granulation (FHMG) technique was used to enhance the solubility and dissolution of simvastatin. Employing meltable hydrophilic binders then converting dispersion into flowable compressible granules yield a rapidly dissolving tablet formulation. Granules prepared by using polymer polyethylene glycol 4000 or 6000, Gelucire 50/13 44/14, Poloxamer 188 407, spray-dried lactose as substrate. The binder for spray in this mixture molten Phase Solubility studies showed an...