A5061278216- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Fungal Biology and Applications
- Drug-Induced Hepatotoxicity and Protection
- Phytochemical Studies and Bioactivities
- Genomics, phytochemicals, and oxidative stress
- Essential Oils and Antimicrobial Activity
- Seed and Plant Biochemistry
- Pharmacological Effects and Assays
- Plant Pathogens and Fungal Diseases
- Synthesis and Biological Activity
- Pharmacology and Obesity Treatment
- Sphingolipid Metabolism and Signaling
- Nephrotoxicity and Medicinal Plants
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Plant Toxicity and Pharmacological Properties
- Identification and Quantification in Food
- Medicinal Plants and Neuroprotection
- Ginger and Zingiberaceae research
- Natural product bioactivities and synthesis
- Botanical Studies and Applications
- Nitrogen and Sulfur Effects on Brassica
Minia University
2011-2025
Heinrich Heine University Düsseldorf
2018
Abstract Background Gastric ulcers represent a worldwide health problem, characterized by erosions that affect the mucous membrane of stomach and may even reach muscular layer, leading to serious complications. Numerous natural products have been assessed as anti-ulcerogenic agents, considered new approaches for treatment or prevention gastric ulcers. The present research investigated preventive benefits Apium graveolens L. (Apiaceae), known celery, seed extract towards indomethacin-induced...
<title>Abstract</title> <italic>Corchorus olitorius</italic> L. Moench (Molokheia) is a common edible plant that rich in terpenoids and flavonoids. Later, for the first time, this article was planned to study potential of <italic>C. roots their nanocrystals against breast cancer (MCF-7), hepatocellular carcinoma (HepG2) colon (Caco-2) cell lines. Generally, total methanolic extract (TMECOR) inhibited growth MCF-7, HepG2 Caco-2 cells with IC<sub>50</sub> values 42.68 ± 1.96, 37.14 1.6 18.63...
The in-vitro anti-proliferative evaluation of Sinularia levi total extract against three cell lines revealed its potent effect Caco-2 line with IC 50 3.3 μg/mL, followed by MCF-7 and HepG-2 6.4 μg/mL 8.5 respectively, in comparison to doxorubicin. Metabolic profiling S . using liquid chromatography coupled high-resolution electrospray ionization mass spectrometry (LC-HR-ESI-MS) the presence phytoconstituents clusters consisting mainly steroids terpenoids (1–20), together five metabolites...
Diabetes mellitus (DM) is a complicated condition that accompanied by plethora of metabolic symptoms, including disturbed serum glucose and lipid profiles. Several herbs are reputed as traditional medicine to improve DM. The current study was designed explore the chemical composition possible ameliorative effects Ocimum forskolei on blood profile in high-fat diet/streptozotocin-induced diabetic rats 3T3-L1 cell lines first report its bioactivity. Histopathological pancreatic adipose tissues...
Broccoli (Brassica oleracea) is reported to possess antioxidant activity that could potentially prevent oxidative damage tissues caused by many diseases. In the present study, we investigated preventive effect of broccoli leaf by-product extract (BL) on gentamicin-induced renal and hepatic injury measuring tissue activities morphological apoptotic changes. was thoroughly extracted with 70% methanol yield total (TME). The phenolic content (TPC) determined. Thirty male rats were divided into...
Gastric ulcers represent a worldwide health problem, characterized by erosions with different degrees in the gastrointestinal mucosa. In current study, we explore protective effects of extract apple seeds (Malus domestica, family: Rosaceae), regarded as environmental wastes, against indomethacin-induced gastric rats. The chemical composition was investigated through liquid chromatography high-resolution electrospray ionization mass spectrometry (LC-HR-ESI-MS). metabolomics profiling resulted...
Cancer continues to be one of the biggest causes death that affects human health. Chemical resistance is still a problem in conventional cancer treatments. Fortunately, numerous natural compounds originating from different microbes, including fungi, possess cytotoxic characteristics are now well known. This study aims investigate anticancer prospects five fungal strains were cultivated and isolated Red Sea soft coral Paralemnalia thyrsoides. The vitro potential ethyl acetate extracts...
Metabolic dysfunctions linked to obesity carry the risk of co-morbidities such as diabetes, hepatorenal, and cardiovascular diseases. Coumarins are believed display several biological effects on diverse adverse health conditions. This study was conducted uncover impact cichoriin high-fat diet (HFD)-induced obese rats. Methods: Obesity induced in twenty rats by exposure an HFD for six weeks. The were randomly divided into five groups; group I comprised healthy considered control one. On other...
Delayed healing of chronic wounds results in amputation and mortality rates serious cases. The present study examines the merged wound-restorative efficacy injectable bone marrow-derived mesenchymal stem cells (BMMSCs) topical Callyspongia sp. extract immunocompromised rats. HR-LC-MS analysis tentatively identified twenty-nine compounds (1-29) highlighted its richness fatty acids terpenoids, known for their wound regenerating efficacies. closure was greatly prominent BMMSCs/Callyspongia...
Abstract Gladiolus segetum Ker‐Gawl corms total extract exhibited remarkable in vitro anti‐proliferative effects against panel of cancer cell lines; including human colon carcinoma (Caco‐2), breast (MCF7) and hepatocellular (HepG2) lines with IC 50 values 7.4, 9.1 11.2 μg/ml, respectively. The ethanolic G. was subjected to untargeted metabolomics profiling using LC‐HR‐ESI‐MS, which revealed the presence various clusters phytoconstituents as triterpenes, anthraquinones, flavonoids phenolic...
Mentha species are medicinally used worldwide and remain attractive for research due to the diversity of their phytoconstituents large therapeutic indices various ailments. This study metabolomics examination five (M. suaveolens, M. sylvestris, piperita, longifolia, viridis) justify cytotoxicity anti-Helicobacter effects. The activities were correlated with phytochemical profiles by orthogonal partial least square discriminant analysis (OPLS-DA). Tentatively characterized using liquid...
Recently, crop byproducts are considered a hot topic and can be converted into beneficial products. Cauliflower is well-known for its protective effects against oxidative stress-induced damage. The current study aimed to investigate the chemical profile ameliorative of cauliflower leaf extract (CL) on gentamicin-induced renal hepatic injuries in rats.Cauliflower was extracted with methanol give total (TME) followed by determination phenolic contents (TPC). Rats were divided five groups;...
Type 2 diabetes mellitus is considered to be a substantial socioeconomic burden worldwide on both patients and governments. Coumarins are biomolecules with diversity of biological activities. The current investigation aimed explore the ameliorative effects cichoriin, which type coumarin, high-fat diet/streptozotocin (HFD/STZ)-induced diabetic rats. Methods: Rats were allocated into five groups. Group I was as control group, while other groups HFD/STZ-induced II assigned control. Groups III...